Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Ciro Coletta"'
Autor:
Celia Chao, John R Zatarain, Ye Ding, Ciro Coletta, Amy A Mrazek, Nadiya Druzhyna, Paul Johnson, Haiying Chen, Judy L Hellmich, Antonia Asimakopoulou, Kazunori Yanagi, Gabor Olah, Petra Szoleczky, Gabor Törö, Fredrick J Bohanon, Minal Cheema, Rachel Lewis, David Eckelbarger, Akbar Ahmad, Katalin Módis, Ashley Untereiner, Bartosz Szczesny, Andreas Papapetropoulos, Jia Zhou, Mark R Hellmich, Csaba Szabo
Publikováno v:
Molecular Medicine, Vol 22, Iss 1, Pp 361-379 (2016)
Abstract Colon cancer cells contain high levels of cystathlonlne-β-synthase (CBS). Its product, hydrogen sulfide (H2S), promotes the growth and proliferation of colorectal tumor cells. To improve the antitumor efficacy of the prototypical CBS inhibi
Externí odkaz:
https://doaj.org/article/82f1dd3cfb1c4158a3de568aaf2f44e0
Autor:
Tonyia Eaves-Pyles, Jignesh Patel, Emma Arigi, Yingzi Cong, Anthony Cao, Nisha Garg, Monisha Dhiman, Richard B. Pyles, Bernard Arulanandam, Aaron L. Miller, Vsevolod L. Popov, Lynn Soong, Eric D. Carlsen, Ciro Coletta, Csaba Szabo, Igor C. Almeida
Publikováno v:
Molecular Medicine, Vol 19, Iss 1, Pp 263-275 (2013)
Abstract Cystatin 9 (CST9) is a member of the type 2 cysteine protease inhibitor family, which has been shown to have immunomodulatory effects that restrain inflammation, but its functions against bacterial infections are unknown. Here, we report tha
Externí odkaz:
https://doaj.org/article/35b85162da3a468382874d1d6b7ae4c4
Autor:
Katalin Módis, Bartosz Szczesny, Jia Zhou, Gabor Olah, Csaba Szabó, Amy A. Mrazek, Haiying Chen, Judy L. Hellmich, Mark R. Hellmich, Andreas Papapetropoulos, Nadiya Druzhyna, Celia Chao, Ashley Untereiner, David Eckelbarger, Paul Johnson, Rachel Lewis, Fredrick J. Bohanon, Gabor Törö, Kazunori Yanagi, Antonia Asimakopoulou, John R. Zatarain, Minal Cheema, Akbar Ahmad, Ciro Coletta, Ye Ding, Petra Szoleczky
Publikováno v:
Molecular Medicine, Vol 22, Iss 1, Pp 361-379 (2016)
Colon cancer cells contain high levels of cystathlonlne-β-synthase (CBS). Its product, hydrogen sulfide (H2S), promotes the growth and proliferation of colorectal tumor cells. To improve the antitumor efficacy of the prototypical CBS inhibitor amino
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1aa0b2024d3ea27c5bd407cb7dc2f187
http://link.springer.com/article/10.2119/molmed.2016.00102
http://link.springer.com/article/10.2119/molmed.2016.00102
Publikováno v:
Antioxidants & Redox Signaling. 22:424-448
Significance: Cancer represents a major socioeconomic problem; there is a significant need for novel therapeutic approaches targeting tumor-specific pathways. Recent Advances: In colorectal and ovarian cancers, an increase in the intratumor productio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0d57d0d9ca77f9900490a458a668320
https://doi.org/10.1089/ars.2014.5933
https://doi.org/10.1089/ars.2014.5933
Autor:
Bartosz Szczesny, Csaba Szabó, Kazunori Yanagi, Andreas Papapetropoulos, Ciro Coletta, Attila Brunyanszki, Ester Rios, Gabor Olah, Akbar Ahmad, Katalin Módis
Publikováno v:
Molecular Medicine. 21:1-14
Hydrogen sulfide (H2S), as a reducing agent and an antioxidant molecule, exerts protective effects against hyperglycemic stress in the vascular endothelium. The mitochondrial enzyme 3-mercaptopyruvate sulfurtransferase (3-MST) is an important biologi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0abdb11bdbcdcd3cfcfcf76bb9241383
https://doi.org/10.2119/molmed.2015.00035
https://doi.org/10.2119/molmed.2015.00035
Autor:
Bartosz Szczesny, Mark R. Hellmich, Antonia Asimakopoulou, Ciro Coletta, Andreas Papapetropoulos, Katalin Módis, Csaba Szabó, Celia Chao
Publikováno v:
Nitric Oxide. 41:146-156
Recent data show that colon cancer cells selectively overexpress cystathionine-β-synthase (CBS), which produces hydrogen sulfide (H2S), to maintain cellular bioenergetics, support tumor growth and stimulate angiogenesis and vasorelaxation in the tum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a5d4176917832be4d1020963b54a032
https://doi.org/10.1016/j.niox.2014.03.001
https://doi.org/10.1016/j.niox.2014.03.001
Autor:
Katalin Módis, Sophie Le Trionnaire, Ciro Coletta, Csaba Szabó, Matthew Whiteman, Bartosz Szczesny, Kazunori Yanagi, Alexis Perry, Mark E. Wood
Publikováno v:
Nitric Oxide. 41:120-130
The purpose of the current study was to investigate the effect of the recently synthesized mitochondrially-targeted H2S donor, AP39 [(10-oxo-10-(4-(3-thioxo-3H-1,2-dithiol-5yl)phenoxy)decyl) triphenylphosphonium bromide], on bioenergetics, viability,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b578315626a70bb7d5feda07ef433d79
https://doi.org/10.1016/j.niox.2014.04.008
https://doi.org/10.1016/j.niox.2014.04.008
Autor:
Frédéric Bouillaud, Ciro Coletta, Céline Ransy, Csaba Szabó, Baptiste Murghes, Katalin Módis, Kazunori Yanagi, Mireille Andriamihaja, Gabor Olah
Publikováno v:
British Journal of Pharmacology. 171:2099-2122
Until recently, hydrogen sulfide (H2S) was exclusively viewed a toxic gas and an environmental hazard, with its toxicity primarily attributed to the inhibition of mitochondrial Complex IV, resulting in a shutdown of mitochondrial electron transport a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::63af2437b366a26f82b1e28494c680a2
https://doi.org/10.1111/bph.12369
https://doi.org/10.1111/bph.12369
Autor:
Harry van Goor, Andreas Papapetropoulos, Ciro Coletta, Mark R. Hellmich, Frédéric Bouillaud, Peter Radermacher, Katalin Módis, Enrico Calzia, Csaba Szabó, Eelke M. Bos
Publikováno v:
British Journal of Pharmacology. 171:2123-2146
Emerging work demonstrates the dual regulation of mitochondrial function by hydrogen sulfide (H2S), including, at lower concentrations, a stimulatory effect as an electron donor, and, at higher concentrations, an inhibitory effect on cytochrome C oxi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a9da269acd86cd7f9fcec78a8cc80bca
https://doi.org/10.1111/bph.12368
https://doi.org/10.1111/bph.12368
Autor:
Tosie Iijima, Mai Niitani, Seiichi Tanaka, Ciro Coletta, Csaba Szabó, Kunihiro Suzuki, Yoshimasa Aso, Kazunori Yanagi
Publikováno v:
Diabetology International. 5:105-111
Angiogenesis is a major physiological response to ischemia that involves development of new capillaries and collateral circulation from preexisting vessels, and endothelial cell (EC) proliferation and migration are crucial events for this process. Ep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f60516e78ae4e220191d69290218df98
https://doi.org/10.1007/s13340-013-0138-7
https://doi.org/10.1007/s13340-013-0138-7