Pathway-Based Similarity Measurement to Quantify Transcriptomics Similarity Between Human Tissues and Preclinical Models.

Autor: Parekh P; Javelin Biotech, Inc., Woburn, Massachusetts, USA., Sherfey J; Javelin Biotech, Inc., Woburn, Massachusetts, USA., Alaybeyoglu B; Javelin Biotech, Inc., Woburn, Massachusetts, USA., Cirit M; Javelin Biotech, Inc., Woburn, Massachusetts, USA.

Publikováno v: Clinical pharmacology and therapeutics [Clin Pharmacol Ther] 2024 Oct 08. Date of Electronic Publication: 2024 Oct 08.

A Novel Milli-fluidic Liver Tissue Chip with Continuous Recirculation for Predictive Pharmacokinetics Applications.

Autor: Rajan SAP; Javelin Biotech Inc, 299 Washington street, Woburn, Massachusetts, 01801, USA., Sherfey J; Javelin Biotech Inc, 299 Washington street, Woburn, Massachusetts, 01801, USA., Ohri S; Javelin Biotech Inc, 299 Washington street, Woburn, Massachusetts, 01801, USA., Nichols L; Javelin Biotech Inc, 299 Washington street, Woburn, Massachusetts, 01801, USA., Smith JT; Javelin Biotech Inc, 299 Washington street, Woburn, Massachusetts, 01801, USA., Parekh P; Javelin Biotech Inc, 299 Washington street, Woburn, Massachusetts, 01801, USA., Kadar EP; Pfizer Global Research and Development, Groton Laboratories, Eastern Point Road, Groton, Connecticut, 06340, USA., Clark F; Pfizer Global Research and Development, Groton Laboratories, Eastern Point Road, Groton, Connecticut, 06340, USA., George BT; Pfizer Global Research and Development, Groton Laboratories, Eastern Point Road, Groton, Connecticut, 06340, USA., Gregory L; Pfizer Global Research and Development, Groton Laboratories, Eastern Point Road, Groton, Connecticut, 06340, USA., Tess D; Pfizer Global Research and Development, Groton Laboratories, Eastern Point Road, Groton, Connecticut, 06340, USA., Gosset JR; Pfizer Worldwide Research and Development, 610 Main Street, Cambridge, Massachusetts, 02139, USA., Liras J; Pfizer Worldwide Research and Development, 610 Main Street, Cambridge, Massachusetts, 02139, USA., Geishecker E; Javelin Biotech Inc, 299 Washington street, Woburn, Massachusetts, 01801, USA., Obach RS; Pfizer Global Research and Development, Groton Laboratories, Eastern Point Road, Groton, Connecticut, 06340, USA., Cirit M; Javelin Biotech Inc, 299 Washington street, Woburn, Massachusetts, 01801, USA. murat@javelinbio.com.

Publikováno v: The AAPS journal [AAPS J] 2023 Oct 27; Vol. 25 (6), pp. 102. Date of Electronic Publication: 2023 Oct 27.

Could SCUBE-1 be a marker for subclinical atherosclerosis other than carotid artery intima-media thickness in patients with psoriasis?

Autor: Ayvaz Çelik HH; Department of Dermatology, Faculty of Medicine, Suleyman Demirel University, Isparta, Turkey. Electronic address: drhhilalayvaz@gmail.com., Kuyumcu MS; Department of Cardiology, Faculty of Medicine, Suleyman Demirel University, Isparta, Turkey., Şirin FB; Department of Biochemistry, Faculty of Medicine, Suleyman Demirel University, Isparta, Turkey., Cirit M; Department of Dermatology, Faculty of Medicine, Suleyman Demirel University, Isparta, Turkey., Korkmaz S; Department of Dermatology, Faculty of Medicine, Suleyman Demirel University, Isparta, Turkey., Erturan İ; Department of Dermatology, Faculty of Medicine, Suleyman Demirel University, Isparta, Turkey., Çelik S; Department of Biochemistry, Faculty of Medicine, Suleyman Demirel University, Isparta, Turkey., Yıldırım M; Department of Dermatology, Faculty of Medicine, Suleyman Demirel University, Isparta, Turkey.

Publikováno v: Anais brasileiros de dermatologia [An Bras Dermatol] 2023 Sep-Oct; Vol. 98 (5), pp. 595-601. Date of Electronic Publication: 2023 May 15.

Inflammatory cytokines and mechanical injury induce post-traumatic osteoarthritis-like changes in a human cartilage-bone-synovium microphysiological system.

Autor: Dwivedi G; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Developmental Biology, Harvard School of Dental Medicine, Boston, MA, USA., Flaman L; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA., Alaybeyoglu B; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Javelin Biotech, Woburn, MA, USA., Struglics A; Department of Clinical Sciences Lund, Orthopaedics, Faculty of Medicine, Lund University, Lund, Sweden., Frank EH; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA., Chubinskya S; Departments of Pediatrics, Orthopedic Surgery and Medicine (Section of Rheumatology), Rush University Medical Center, Chicago, IL, USA., Trippel SB; Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, IN, USA., Rosen V; Department of Developmental Biology, Harvard School of Dental Medicine, Boston, MA, USA., Cirit M; Javelin Biotech, Woburn, MA, USA., Grodzinsky AJ; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA. alg@mit.edu.; Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, USA. alg@mit.edu.; Department of Mechanical Engineering, Massachusetts Institute of Technology, NE47-377, 500 Technology Square, Cambridge, MA, 02139, USA. alg@mit.edu.

Publikováno v: Arthritis research & therapy [Arthritis Res Ther] 2022 Aug 18; Vol. 24 (1), pp. 198. Date of Electronic Publication: 2022 Aug 18.

Quantitative systems pharmacology in neuroscience: Novel methodologies and technologies.

Autor: Bloomingdale P; Quantitative Pharmacology and Pharmacometrics, Merck & Co. Inc, Kenilworth, New Jersey, USA., Karelina T; InSysBio, Moscow, Russia., Cirit M; Javelin Biotech, Inc, Woburn, Massachusetts, USA., Muldoon SF; Mathematics Department, CDSE Program, Neuroscience Program, University at Buffalo, SUNY, Buffalo, New York, USA., Baker J; Harvard Medical School, Boston, Massachusetts, USA., McCarty WJ; Skyhawk Therapeutics, Waltham, Massachusetts, USA., Geerts H; Certara, QSP, Berwyn, Pennsylvania, USA., Macha S; Quantitative Pharmacology, Sanofi, Bridgewater, New Jersey, USA.

Publikováno v: CPT: pharmacometrics & systems pharmacology [CPT Pharmacometrics Syst Pharmacol] 2021 May; Vol. 10 (5), pp. 412-419. Date of Electronic Publication: 2021 Mar 29.