Platelet and Endothelial Activation as Potential Mechanisms Behind the Thrombotic Complications of COVID-19 Patients

Autor: Daniele Andreini, Fabrizio Veglia, Marta Brambilla, Alice Bonomi, Benedetta Porro, Martino F. Pengo, Viviana Cavalca, Stefano Vicini, Marina Camera, Paola Canzano, Daniela Trabattoni, Andrea Cascella, Paolo Poggio, Elena Tortorici, Emanuela Omodeo Salè, Susanna Fiorelli, Gianfranco Parati, Elena Tremoli, Nicola Cosentino

Publikováno v: JACC: Basic to Translational Science

The authors hypothesized that the cytokine storm described in COVID-19 patients may lead to consistent cell-based tissue factor (TF)-mediated activation of coagulation, procoagulant microvesicles (MVs) release, and massive platelet activation. COVID-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3145c7f8703ec10f954c6d7b8fc33871
https://doi.org/10.1016/j.jacbts.2020.12.009

Prognostic Value of Circulating Microvesicle Subpopulations in Ischemic Stroke and TIA

Autor: Magnus von Arbin, Elisabeth Rooth, Ann Charlotte Laska, Håkan Wallén, Charlotte Thålin, Fariborz Mobarrez, Annika Lundström, Bruna Gigante, Peter Henriksson

Publikováno v: Translational Stroke Research

Platelet microvesicles (PMV) have previously been found elevated in acute ischemic stroke (IS) and could be biomarkers for risk of recurrence. PMV surface antigens such as P-selectin and phosphatidylserine (PS) reflect platelet activation and procoag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44c764962deef869575f9f42f1ea7ea4
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-419776

Circulating microvesicle number, function and small RNA content vary with age, gender, smoking status, lipid and hormone profiles

Autor: Lisa F. Lincz, Angel D'Crus, Anoop K Enjeti, Anita Ariyarajah, Michael Seldon

Publikováno v: Thrombosis Research. 156:65-72

Characterization of circulating microvesicles (MV) in healthy subjects in relation to various biological factors is not well studied.We evaluated the influence of age, gender, smoking status, lipid and hormone profiles on circulating MV in healthy su

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4b70212095574d849f3936f1628b103
https://doi.org/10.1016/j.thromres.2017.04.019

Microvesicles in vascular homeostasis and diseases

Autor: Victoria C. Ridger, Chantal M. Boulanger, Anne Angelillo-Scherrer, Lina Badimon, Olivier Blanc-Brude, Marie-Luce Bochaton-Piallat, Eric Boilard, Edit I. Buzas, Andreas Caporali, Francoise Dignat-George, Paul C. Evans, Romaric Lacroix, Esther Lutgens, Daniel F. J. Ketelhuth, Rienk Nieuwland, Florence Toti, Jose Tuñon, Christian Weber, Imo E. Hoefer, Gregory Y. H. Lip, Nikos Werner, Eduard Shantsila, Hugo ten Cate, Mark Thomas, Paul Harrison

Publikováno v: Thrombosis and Haemostasis
Thrombosis and Haemostasis, 2017, 117 (07), pp.1296-1316. ⟨10.1160/TH16-12-0943⟩
Thrombosis and Haemostasis, Vol. 117, No 7 (2017) pp. 1296-1316
Thrombosis and haemostasis, 117(7), 1296-1316. Schattauer GmbH
Thrombosis and Haemostasis, 117(7), 1296-1316. Georg Thieme Verlag
THROMBOSIS AND HAEMOSTASIS
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname

SummaryMicrovesicles are members of the family of extracellular vesicles shed from the plasma membrane of activated or apoptotic cells. Microvesicles were initially characterised by their pro-coagulant activity and described as “microparticles”.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6ff7832ebf3b917f524aede8c2a42f8
https://doi.org/10.1160/th16-12-0943

Pancreatic cancer-derived exosomes: new role in paraneoplastic syndromes?

Autor: Chi Lam Au Yeung, Samuel C. Mok

Publikováno v: Translational Cancer Research. 5:S697-S700

Recent studies show that cells can communicate through the exchange of bioactive molecules via microvesicles. These small vesicles include ectosomes (100–1,000 nm) and exosomes (30–100 nm), which are shed or secreted by almost all cell types (1).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::52f82aa00db8dbf67b5609e6534ce708
https://doi.org/10.21037/tcr.2016.10.94