Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Circadian Rhythm/genetics"'
Autor:
James S Bagnall, Alex A Koch, Nicola J Smyllie, Nicola Begley, Antony D Adamson, Jennifer L Fribourgh, David G Spiller, Qing-Jun Meng, Carrie L Partch, Korbinian Strimmer, Thomas A House, Michael H Hastings, Andrew SI Loudon
Publikováno v:
Koch, A, Bagnall, J, Smyllie, N J, Begley, N, Adamson, A, Fribourgh, J L, Spiller, D, Meng, Q-J, Partch, C L, Strimmer, K, House, T, Hastings, M H & Loudon, A 2022, ' Quantification of protein abundance and interaction defines a mechanism for operation of the circadian clock ', eLife, vol. 11, e73976 . https://doi.org/10.7554/eLife.73976
The mammalian circadian clock exerts control of daily gene expression through cycles of DNA binding. Here, we develop a quantitative model of how a finite pool of BMAL1 protein can regulate thousands of target sites over daily time scales. We used qu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bda5ec2b702d72fdf720c555831088b1
https://research.manchester.ac.uk/en/publications/238e144d-a42e-4255-b827-1bca6bd15350
https://research.manchester.ac.uk/en/publications/238e144d-a42e-4255-b827-1bca6bd15350
Publikováno v:
Briefings in functional genomics, vol. 19, no. 5-6, pp. 343-349
Aging and circadian rhythms are two biological processes that affect an organism, although at different time scales. Nevertheless, due to the overlap of their actions, it was speculated that both interfere or interact with each other. However, to add
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______1900::9d4c9b82add1b07fcfac332e0e5f711d
https://serval.unil.ch/notice/serval:BIB_0223DAE8F649
https://serval.unil.ch/notice/serval:BIB_0223DAE8F649
Publikováno v:
eLife, Vol 10 (2021)
eLife
eLife, vol. 10, pp. e69773
eLife
eLife, vol. 10, pp. e69773
In the mouse, Period-2 (Per2) expression in tissues peripheral to the suprachiasmatic nuclei (SCN) increases during sleep deprivation and at times of the day when animals are predominantly awake spontaneously, suggesting that the circadian sleep-wake
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0147090e838c812314de697965091627
https://doi.org/10.1101/2020.07.25.221101
https://doi.org/10.1101/2020.07.25.221101
Autor:
Bart Deplancke, Frédéric Schütz, Nouria Hernandez, Federica Gilardi, Nicolas GUEX, Leonor Rib, Ian Willis, Beatrice Desvergne
Publikováno v:
Genome research, vol. 27, no. 6, pp. 973-984
RNA polymerase III (Pol III) synthesizes short noncoding RNAs, many of which are essential for translation. Accordingly, Pol III activity is tightly regulated with cell growth and proliferation by factors such as MYC, RB1, TRP53, and MAF1. MAF1 is a
Autor:
Romolo Caniglia, Pavel Hulva, Marco Galaverni, Alessio Camatta, Paolo Carnier, Ihor Dykyy, Elena Fabbri, Milena Jindřichová, Ettore Randi, Astrid Vik Stronen, Barbora Černá Bolfíková
Publikováno v:
Caniglia, R, Fabbri, E, Hulva, P, Bolfíková, B Č, Jindřichová, M, Strønen, A V, Dykyy, I, Camatta, A, Carnier, P, Randi, E & Galaverni, M 2018, ' Wolf outside, dog inside? The genomic make-up of the Czechoslovakian Wolfdog ', B M C Genomics, vol. 19, no. 1, 533 . https://doi.org/10.1186/s12864-018-4916-2
BMC Genomics
BMC Genomics, Vol 19, Iss 1, Pp 1-17 (2018)
BMC Genomics
BMC Genomics, Vol 19, Iss 1, Pp 1-17 (2018)
Background Genomic methods can provide extraordinary tools to explore the genetic background of wild species and domestic breeds, optimize breeding practices, monitor and limit the spread of recessive diseases, and discourage illegal crossings. In th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bcf462cb65f54d1686951e924a04d6f
https://vbn.aau.dk/ws/files/292019951/s12864_018_4916_2.pdf
https://vbn.aau.dk/ws/files/292019951/s12864_018_4916_2.pdf
Autor:
Gorazd Rudolf, Maja Živković, Luca Lovrečić, Saša Šega Jazbec, Evica Dinčić, Alenka Hodžić, Nada Starčević Čizmarević, Polona Lavtar, Ranko Raicevic, Miljenko Kapović, Juraj Sepčić, Smiljana Ristić, Zalika Klemenc Ketiš, Aleš Maver, Aleksandra Stanković, Borut Peterlin
Publikováno v:
PLoS ONE
PLOS One
PLoS ONE, Vol 13, Iss 1, p e0190601 (2018)
Volume 13
Issue 1
PLOS One
PLoS ONE, Vol 13, Iss 1, p e0190601 (2018)
Volume 13
Issue 1
Prevalence of multiple sclerosis varies with geographic latitude. We hypothesized that this fact might be partially associated with the influence of latitude on circadian rhythm and consequently that genetic variability of key circadian rhythm regula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bfea3f715ebbda6101bf2bf960db8d9
https://www.bib.irb.hr/919723
https://www.bib.irb.hr/919723
Publikováno v:
Genome biology, vol. 18, no. 1, pp. 116
Genome Biology
Genome Biology, Vol 18, Iss 1, Pp 1-17 (2017)
Genome Biology
Genome Biology, Vol 18, Iss 1, Pp 1-17 (2017)
Background The daily gene expression oscillations that underlie mammalian circadian rhythms show striking differences between tissues and involve post-transcriptional regulation. Both aspects remain poorly understood. We have used ribosome profiling
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::179c8633b8c4fb2d95399040fbe7146b
https://serval.unil.ch/notice/serval:BIB_3F3B91FFCF68
https://serval.unil.ch/notice/serval:BIB_3F3B91FFCF68
Autor:
Eva Martin, Mojgan Masoodi, Céline Jouffe, Sylviane Metairon, Delphine Morin-Rivron, Cédric Gobet, Frédéric Gachon
Publikováno v:
Scientific Reports
Scientific reports, vol. 6, pp. 24631
Scientific reports, vol. 6, pp. 24631
Through evolution, most of the living species have acquired a time keeping system to anticipate daily changes caused by the rotation of the Earth. In all of the systems this pacemaker is based on a molecular transcriptional/translational negative fee
Autor:
Sandrine M. Dupre, Alison Downing, Daphne Mouzaki, Richard Talbot, Dave Burt, Benoît Malpaux, D. Waddington, Gerald A. Lincoln, Andrew S. I. Loudon, Julian R. E. Davis
Publikováno v:
Endocrinology
Endocrinology, Endocrine Society, 2008, 149 (11), pp.5527-5539. ⟨10.1210/en.2008-0834⟩
Dupre, S M, Burt, D W, Talbot, R, Downing, A, Mouzaki, D, Waddington, D, Malpaux, B, Davis, J R E, Lincoln, G A & Loudon, A S I 2008, ' Identification of Melatonin-Regulated Genes in the Ovine Pituitary Pars Tuberalis, a Target Site for Seasonal Hormone Control ', Endocrinology, vol. 149, no. 11, pp. 5527-5539 . https://doi.org/10.1210/en.2008-0834
Endocrinology, Endocrine Society, 2008, 149 (11), pp.5527-5539. ⟨10.1210/en.2008-0834⟩
Dupre, S M, Burt, D W, Talbot, R, Downing, A, Mouzaki, D, Waddington, D, Malpaux, B, Davis, J R E, Lincoln, G A & Loudon, A S I 2008, ' Identification of Melatonin-Regulated Genes in the Ovine Pituitary Pars Tuberalis, a Target Site for Seasonal Hormone Control ', Endocrinology, vol. 149, no. 11, pp. 5527-5539 . https://doi.org/10.1210/en.2008-0834
International audience; The pars tuberalis (PT) of the pituitary gland expresses a high density of melatonin (MEL) receptors and is believed to regulate seasonal physiology by decoding changes in nocturnal melatonin secretion. Circadian clock genes a
Publikováno v:
Genome Research, vol. 25, no. 12, pp. 1848-1859
Genome Research
Genome Research
Mammalian gene expression displays widespread circadian oscillations. Rhythmic transcription underlies the core clock mechanism, but it cannot explain numerous observations made at the level of protein rhythmicity. We have used ribosome profiling in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f99c00651af2d4e45cb9849d91e61dd6
https://serval.unil.ch/notice/serval:BIB_5CC6939B3A97
https://serval.unil.ch/notice/serval:BIB_5CC6939B3A97