Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Cionne N, Manning"'
Autor:
Stavros Thomopoulos, Cionne N. Manning, Matthew J. Silva, Elisa Knutsen, Richard H. Gelberman, Shelly E. Sakiyama-Elbert, Necat Havlioglu
Publikováno v:
Journal of Orthopaedic Research. 32:645-652
Despite advances in surgical techniques over the past three decades, tendon repairs remain prone to poor clinical outcomes. Previous attempts to improve tendon healing have focused on the later stages of healing (i.e., proliferation and matrix synthe
Publikováno v:
ACS Applied Materials & Interfaces
Reattachment of tendon to bone has been a challenge in orthopedic surgery. The disparate mechanical properties of the two tissues make it difficult to achieve direct surgical repair of the tendon-to-bone insertion. Healing after surgical repair typic
Autor:
Richard H. Gelberman, H. Mike Kim, Ryan Potter, Eleni Ntouvali, Cionne N. Manning, Stavros Thomopoulos, Howard Cambridge Seeherman, Matthew J. Silva
Publikováno v:
Journal of Orthopaedic Research. 30:1702-1709
Tendon-to-bone healing is typically poor, with a high rate of repair-site rupture. Bone loss after tendon-to-bone repair may contribute to poor outcomes. Therefore, we hypothesized that the local application of the osteogenic growth factor bone morph
Autor:
Cionne N. Manning, Leesa M. Galatz, Shelly E. Sakiyama-Elbert, H. Mike Kim, Necat Havlioglu, Stavros Thomopoulos
Publikováno v:
Journal of Orthopaedic Research. 29:1099-1105
Despite advances in surgical technique, rotator cuff repairs are plagued by a high rate of failure. This failure rate is in part due to poor tendon-to-bone healing; rather than regeneration of a fibrocartilaginous attachment, the repair is filled wit
Autor:
Matthew J. Silva, Stavros Thomopoulos, Cionne N. Manning, Catherine Martel, Richard H. Gelberman, Shivam A. Shah, Shelly E. Sakiyama-Elbert
Publikováno v:
Stem Cell Research & Therapy
Introduction Macrophage-driven inflammation is a key feature of the early period following tendon repair, but excessive inflammation has been associated with poor clinical outcomes. Modulation of the inflammatory environment using molecular or cellul
Autor:
Cionne N. Manning, Andrea G. Schwartz, Shelly E. Sakiyama-Elbert, Wenying Liu, Younan Xia, Jingwei Xie, Necat Havlioglu, Matthew J. Silva, Stavros Thomopoulos, Richard H. Gelberman
Publikováno v:
Acta biomaterialia. 9(6)
Outcomes after tendon repair are often unsatisfactory, despite improvements in surgical techniques and rehabilitation methods. Recent studies aimed at enhancing repair have targeted the paucicellular nature of tendon for enhancing repair; however, mo
Autor:
Stavros, Thomopoulos, H Mike, Kim, Matthew J, Silva, Eleni, Ntouvali, Cionne N, Manning, Ryan, Potter, Howard, Seeherman, Richard H, Gelberman
Publikováno v:
Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 30(11)
Tendon-to-bone healing is typically poor, with a high rate of repair-site rupture. Bone loss after tendon-to-bone repair may contribute to poor outcomes. Therefore, we hypothesized that the local application of the osteogenic growth factor bone morph
Autor:
Cionne N, Manning, H Mike, Kim, Shelly, Sakiyama-Elbert, Leesa M, Galatz, Necat, Havlioglu, Stavros, Thomopoulos
Publikováno v:
Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 29(7)
Despite advances in surgical technique, rotator cuff repairs are plagued by a high rate of failure. This failure rate is in part due to poor tendon-to-bone healing; rather than regeneration of a fibrocartilaginous attachment, the repair is filled wit
Autor:
Cionne N. Manning, Younan Xia, Justin Lipner, Andrea G. Schwartz, Stavros Thomopoulos, Jingwei Xie, Xiaoran Li
Publikováno v:
Nanoscale. 2:923
We have demonstrated the fabrication of “aligned-to-random” electrospun nanofiber scaffolds that mimic the structural organization of collagen fibers at the tendon-to-bone insertion site. Tendon fibroblasts cultured on such a scaffold exhibited h