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Akademický článek

E proteins control the development of NKγδT cells through their invariant T cell receptor

Autor: Ariana Mihai, Sang-Yun Lee, Susan Shinton, Mitchell I. Parker, Alejandra V. Contreras, Baojun Zhang, Michele Rhodes, Roland L. Dunbrack, Juan-Carlos Zúñiga-Pflücker, Maria Ciofani, Yuan Zhuang, David L. Wiest

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)

Abstract T cell receptor (TCR) signaling regulates important developmental transitions, partly through induction of the E protein antagonist, Id3. Although normal γδ T cell development depends on Id3, Id3 deficiency produces different phenotypes in

Externí odkaz: https://doaj.org/article/f10d24a302ee49119e6cd90778ad9580

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Akademický článek

Machine-learning based risk prediction of in-hospital outcomes following STEMI: the STEMI-ML score

Autor: Hari P. Sritharan, Harrison Nguyen, Jonathan Ciofani, Ravinay Bhindi, Usaid K. Allahwala

Publikováno v: Frontiers in Cardiovascular Medicine, Vol 11 (2024)

BackgroundTraditional prognostic models for ST-segment elevation myocardial infarction (STEMI) have limitations in statistical methods and usability.ObjectiveWe aimed to develop a machine-learning (ML) based risk score to predict in-hospital mortalit

Externí odkaz: https://doaj.org/article/ec4e25e1630e416a8dd8d09ac513c78f

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Akademický článek

Advances in the Computational Assessment of Disturbed Coronary Flow and Wall Shear Stress: A Contemporary Review

Autor: Avedis Assadour Ekmejian, Harry James Carpenter, Jonathan Laurence Ciofani, Benjamin Howard McIntosh Gray, Usaid Khalil Allahwala, Michael Ward, Javier Escaned, Peter James Psaltis, Ravinay Bhindi

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 19 (2024)

Coronary artery blood flow is influenced by various factors including vessel geometry, hemodynamic conditions, timing in the cardiac cycle, and rheological conditions. Multiple patterns of disturbed coronary flow may occur when blood flow separates f

Externí odkaz: https://doaj.org/article/f60ba8c13a9f453ca414e16a9ee7ae2c

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Akademický článek

Remotely Controlled 3D‐Engineered Scaffolds for Biomimetic In Vitro Investigations on Brain Cell Cocultures

Autor: Daniele De Pasquale, Attilio Marino, Carlotta Pucci, Omar Tricinci, Carlo Filippeschi, Pietro Fiaschi, Edoardo Sinibaldi, Gianni Ciofani

Publikováno v: Advanced Intelligent Systems, Vol 6, Iss 9, Pp n/a-n/a (2024)

Most in vitro studies regarding new anticancer treatments are performed on 2D cultures, despite this approach imposes several limitations in recapitulating the real tumor behavior and in predicting the effects of therapy on both cancer and healthy ti

Externí odkaz: https://doaj.org/article/92ccabcfdc8b4dd6a28384deb699d208

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Akademický článek

Photoacoustic features of nylon-11 nanoparticles for breast cancer imaging, and their modification with trastuzumab, sorafenib, and nutlin-3a for theranostic applications

Autor: Özlem Şen, Paolo Armanetti, Alessio Carmignani, Federico Catalano, Giammarino Pugliese, Luca Menichetti, Gianni Ciofani

Publikováno v: Nano Trends, Vol 7, Iss , Pp 100047- (2024)

Breast cancer is a complex and diverse disease that requires accurate diagnostic methods and customized treatment approaches to enhance patient outcomes. In this study, we investigate the potential of nylon-11 nanoparticles (nylon NPs) for both imagi

Externí odkaz: https://doaj.org/article/5c4f0e678a9040f7816cd01979cab22e

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