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Akademický článek

Site‐Specific Load‐Induced Expansion of Sca‐1+Prrx1+ and Sca‐1−Prrx1+ Cells in Adult Mouse Long Bone Is Attenuated With Age

Autor: Pamela Cabahug‐Zuckerman, Chao Liu, Cinyee Cai, Ian Mahaffey, Stephanie C Norman, Whitney Cole, Alesha B Castillo

Publikováno v: JBMR Plus, Vol 3, Iss 9, Pp n/a-n/a (2019)

ABSTRACT Aging is associated with significant bone loss and increased fracture risk, which has been attributed to a diminished response to anabolic mechanical loading. In adults, skeletal progenitors proliferate and differentiate into bone‐forming

Externí odkaz: https://doaj.org/article/33696c7a68a54521837771116a137f65

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CXCL12 in late-stage osteoblasts and osteocytes is required for load-induced bone formation in mice

Autor: Pamela Cabahug-Zuckerman, Chao Liu, Pablo Atria, Cinyee Cai, Emily Fang, Shahar Qureshi, Rikki Rooklin, Cesar Ponce, Camila Morocho, Alesha B. Castillo

Increased physical loading of the skeleton activates new bone formation ensuring its ability to meet mechanical demands over time; however, the capacity of bone to respond to mechanical stimulation diminishes with age. Osteocytes, the cells embedded

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::62bee843e4425014e932205f35156474
https://doi.org/10.1101/2022.08.25.505279

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Site‐Specific Load‐Induced Expansion of Sca‐1 + Prrx1 + and Sca‐1 − Prrx1 + Cells in Adult Mouse Long Bone Is Attenuated With Age

Autor: Stephanie C Norman, Alesha B. Castillo, Whitney Cole, Cinyee Cai, Pamela Cabahug-Zuckerman, Chao Liu, Ian Mahaffey

Publikováno v: JBMR Plus. 3

Aging is associated with significant bone loss and increased fracture risk, which has been attributed to a diminished response to anabolic mechanical loading. In adults, skeletal progenitors proliferate and differentiate into bone-forming osteoblasts

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::422594e8feea4776d6d2bdaf6eeab6a4
https://doi.org/10.1002/jbm4.10199

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Mechanical loading promotes the expansion of primitive osteoprogenitors and organizes matrix and vascular morphology in long bone defects

Autor: Pamela Cabahug-Zuckerman, Chao Liu, Alesha B. Castillo, Christopher J. Stubbs, Kenneth A. Mann, Cinyee Cai, Martin Pendola

Publikováno v: J Bone Miner Res

Elucidating the effects of mechanical stimulation on bone repair is crucial for optimization of the healing process. Specifically, the regulatory role that mechanical loading exerts on the osteogenic stem cell pool and vascular morphology during heal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc980aa3ea6aa111eccecbe036572d8d
https://europepmc.org/articles/PMC8263903/

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