Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Cintyu Wong"'
Autor:
Deyu Li, James C. Delaney, Charlotte M. Page, Alvin S. Chen, Cintyu Wong, Catherine L. Drennan, John M. Essigmann
Publikováno v:
Journal of Nucleic Acids, Vol 2010 (2010)
DNA alkylation can cause mutations, epigenetic changes, and even cell death. All living organisms have evolved enzymatic and non-enzymatic strategies for repairing such alkylation damage. AlkB, one of the Escherichia coli adaptive response proteins,
Externí odkaz:
https://doaj.org/article/72c0ce95c6494c019c622d58039844e0
Autor:
Nidhi Shrivastav, Catherine L. Drennan, Deyu Li, James C. Delaney, Bogdan I. Fedeles, Xuedong Yang, John M. Essigmann, Cintyu Wong
Publikováno v:
Chemical Research in Toxicology
The AlkB enzyme is an Fe(II)- and α-ketoglutarate-dependent dioxygenase that repairs DNA alkyl lesions by a direct reversal of damage mechanism as part of the adaptive response in E. coli. The reported substrate scope of AlkB includes simple DNA alk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00325b05107ba96e56b0023b2cb30263
https://doi.org/10.1021/tx400096m
https://doi.org/10.1021/tx400096m
Publikováno v:
Journal of Chromatography A. 1270:153-161
Oxidation in therapeutic monoclonal antibody is a common occurrence and it may affect potency. Thus controlling and monitoring the amount of oxidized variant in the drug product sample is important since it may impact the purity. Here, we present the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60acd83ee2d0205277dde0de4ef548c6
https://doi.org/10.1016/j.chroma.2012.10.064
https://doi.org/10.1016/j.chroma.2012.10.064
Autor:
Sean Elliott, Cintyu Wong, Nicholas C. Bene, Marco Jost, Catherine L. Drennan, Michael J. Hamill
Publikováno v:
International Journal of Molecular Sciences, Vol 13, Iss 12, Pp 16899-16915 (2012)
International Journal of Molecular Sciences
Volume 13
Issue 12
Pages 16899-16915
MDPI Publishing
International Journal of Molecular Sciences
Volume 13
Issue 12
Pages 16899-16915
MDPI Publishing
When exposed to known DNA-damaging alkylating agents, Escherichia coli cells increase production of four DNA repair enzymes: Ada, AlkA, AlkB, and AidB. The role of three enzymes (Ada, AlkA, and AlkB) in repairing DNA lesions has been well characteriz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b0bc028dbc7b0a21cbc70b1e43811fe
http://www.mdpi.com/1422-0067/13/12/16899
http://www.mdpi.com/1422-0067/13/12/16899
Autor:
Xuedong Yang, James C. Delaney, John M. Essigmann, Deyu Li, Charlotte M. Page, Alvin S. Chen, Cintyu Wong, Catherine L. Drennan
Publikováno v:
Journal of the American Chemical Society
The DNA and RNA repair protein AlkB removes alkyl groups from nucleic acids by a unique iron- and α-ketoglutarate-dependent oxidation strategy. When alkylated adenines are used as AlkB targets, earlier work suggests that the initial target of oxidat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72248b98eda1f7bbb51506d758967937
https://doi.org/10.1021/ja3010094
https://doi.org/10.1021/ja3010094
Publikováno v:
Biochemistry
Exposure of Escherichia coli cells to small doses of DNA-methylating agents initiates a response that mitigates the mutagenic and cytotoxic effects of DNA methylation.1−3 This process, known as the adaptive response, involves the upregulation of fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5297c91cca277f09f202d7bfaeb7c62d
https://doi.org/10.1021/bi201340t
https://doi.org/10.1021/bi201340t
Publikováno v:
Journal of the American Chemical Society
CytC3, a member of the recently discovered class of nonheme Fe(II) and alpha-ketoglutarate (alphaKG)-dependent halogenases, catalyzes the double chlorination of L-2-aminobutyric acid (Aba) to produce a known Streptomyces antibiotic, gamma,gamma-dichl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98de88a617bcb09e1efcdf441b3d5999
https://doi.org/10.1021/ja8097355
https://doi.org/10.1021/ja8097355
Publikováno v:
Proceedings of the National Academy of Sciences. 104:755-760
1, N 6 -ethanoadenine (EA) forms through the reaction of adenine in DNA with the antitumor agent 1,3-bis(2-chloroethyl)-1-nitrosourea, a chemotherapeutic used to combat various brain, head, and neck tumors. Previous studies of the toxic and mutagenic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6de3d5c4d8c828d9fe50992e18193cc4
https://doi.org/10.1073/pnas.0607377104
https://doi.org/10.1073/pnas.0607377104
Autor:
Cintyu Wong, Catherine L. Drennan, Leona D. Samson, Lauren E. Frick, Lisa Smeester, John M. Essigmann, Koli Taghizadeh, John S. Wishnok, James C. Delaney
Publikováno v:
Nature Structural & Molecular Biology. 12:855-860
Oxidative stress converts lipids into DNA-damaging agents. The genomic lesions formed include 1,N(6)-ethenoadenine (epsilonA) and 3,N(4)-ethenocytosine (epsilonC), in which two carbons of the lipid alkyl chain form an exocyclic adduct with a DNA base
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3293fbc847292ba7773699a870ddc039
https://doi.org/10.1038/nsmb996
https://doi.org/10.1038/nsmb996
Autor:
Charlotte M. Page, Deyu Li, Catherine L. Drennan, Cintyu Wong, James C. Delaney, John M. Essigmann, Alvin S. Chen
Publikováno v:
Journal of Nucleic Acids, Vol 2010 (2010)
Journal of Nucleic Acids
Journal of Nucleic Acids
DNA alkylation can cause mutations, epigenetic changes, and even cell death. All living organisms have evolved enzymatic and non-enzymatic strategies for repairing such alkylation damage. AlkB, one of theEscherichia coliadaptive response proteins, us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63dbe19348b905f60681bde6ffdadd68
https://doaj.org/article/72c0ce95c6494c019c622d58039844e0
https://doaj.org/article/72c0ce95c6494c019c622d58039844e0