Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Cintya Lopez-Lopez"'
Autor:
Giada De Palma, Chiko Shimbori, David E. Reed, Yang Yu, Virginia Rabbia, Jun Lu, Nestor Jimenez-Vargas, Jessica Sessenwein, Cintya Lopez-Lopez, Marc Pigrau, Josue Jaramillo-Polanco, Yong Zhang, Lauren Baerg, Ahmad Manzar, Julien Pujo, Xiaopeng Bai, Maria Ines Pinto-Sanchez, Alberto Caminero, Karen Madsen, Michael G. Surette, Michael Beyak, Alan E. Lomax, Elena F. Verdu, Stephen M. Collins, Stephen J. Vanner, Premysl Bercik
Publikováno v:
Science translational medicine. 14(655)
The gut microbiota has been implicated in chronic pain disorders, including irritable bowel syndrome (IBS), yet specific pathophysiological mechanisms remain unclear. We showed that decreasing intake of fermentable carbohydrates improved abdominal pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38694ecd5d2f04eb54b775b1b3398233
https://pubmed.ncbi.nlm.nih.gov/35982254
https://pubmed.ncbi.nlm.nih.gov/35982254
Autor:
Caroline J Tuck, Amal Abu Omar, Giada De Palma, Samira Osman, Nestor N Jiménez-Vargas, Yang Yu, Sean MP Bennet, Cintya Lopez-Lopez, Josue O Jaramillo-Polanco, Corey C Baker, Aidan SW Bennett, Mabel Guzman-Rodriguez, Quentin Tsang, Taylor Alward, Sebastien Rolland, Celine Morissette, Elena F Verdu, Premysl Bercik, Stephen J Vanner, Alan E Lomax, David E Reed
Publikováno v:
Gut. :gutjnl-2022
ObjectiveDietary therapies for irritable bowel syndrome (IBS) have received increasing interest but predicting which patients will benefit remains a challenge due to a lack of mechanistic insight. We recently found evidence of a role for the microbio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4908c0706ffcdd956c9483a13d0b9378
https://doi.org/10.1136/gutjnl-2022-327260
https://doi.org/10.1136/gutjnl-2022-327260
Autor:
Shavonne Teng, Stephen Vanner, Alan Hegron, Jesse J. DiCello, Yang Yu, Josue Jaramillo-Polanco, Michelle L. Halls, Daniel P. Poole, Dane D. Jensen, Nicholas A. Veldhuis, Kam W. Leong, Nestor N. Jiménez-Vargas, Meritxell Canals, Brian L. Schmidt, Cintya Lopez-Lopez, Jing Gong, Alan E. Lomax, Simona E. Carbone, Matthew J. Wisdom, David E. Reed, Pradeep Rajasekhar, Nigel W. Bunnett, Rocco Latorre
Publikováno v:
Proc Natl Acad Sci U S A
Whether G protein-coupled receptors signal from endosomes to control important pathophysiological processes and are therapeutic targets is uncertain. We report that opioids from the inflamed colon activate δ-opioid receptors (DOPr) in endosomes of n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77a17ff512ec645e122b6824c448c7ae
https://pubmed.ncbi.nlm.nih.gov/32546520
https://pubmed.ncbi.nlm.nih.gov/32546520
Autor:
Lisse Decraecker, Raf Bisschops, Stavroula Theofanous, Bart N. Lambrecht, Javier Aguilera-Lizarraga, Morgane Florens, Alexandre Denadai-Souza, Frank A. Redegeld, Josue Jaramillo-Polanco, Jiyeon Si, Kim Van Beek, Mira M. Wouters, Yeranddy A. Alpizar, Gianluca Matteoli, Naomi Fabre, Dafne Balemans, Rik Schrijvers, Guy E. Boeckxstaens, Stephanie Mondelaers, Sven Hendrix, David E. Reed, Maria Cuende-Estevez, Hans-Reimer Rodewald, Cedric Bosteels, Sales Ibiza Martínez, Maxim Nelis, Goele Bosmans, Piyush Jain, Eluisa Perna, Nathalie Stakenborg, Deirdre Cabooter, Ramona A. Hoh, Maria Francesca Viola, Jessica Strid, Patrick Augustijns, Ricard Farré, Scott D. Boyd, Iris Appeltans, Cintya Lopez-Lopez, Christine Breynaert, Karel Talavera, Stephen Vanner, Thorsten B. Feyerabend, Jeroen Raes
Publikováno v:
Nature, 590(7844), 151. Nature Research
Nature, 590(7844), 151-156. Nature Publishing Group
NATURE
Nature
Nature, 590(7844), 151-156. Nature Publishing Group
NATURE
Nature
Up to 20% of people worldwide develop gastrointestinal symptoms following a meal(1), leading to decreased quality of life, substantial morbidity and high medical costs. Although the interest of both the scientific and lay communities in this issue ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0e91a752e8dd8c5c1ea92d7674bf672
https://pubmed.ncbi.nlm.nih.gov/33526865
https://pubmed.ncbi.nlm.nih.gov/33526865
Autor:
Takanobu Okamoto, Raquel Guerrero-Alba, Nigel W. Bunnett, Stephen Vanner, Eduardo E. Valdez-Morales, Nestor N. Jiménez-Vargas, Alan E. Lomax, Cintya Lopez-Lopez, Yasmin Nasser, Josue Jaramillo-Polanco
Publikováno v:
Gut
Aims and backgroundPsychological stress accompanies chronic inflammatory diseases such as IBD, and stress hormones can exacerbate pain signalling. In contrast, the endogenous opioid system has an important analgesic action during chronic inflammation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0f2006acefd5d0712166cf1e4560b96
https://doi.org/10.1136/gutjnl-2016-311456
https://doi.org/10.1136/gutjnl-2016-311456
Autor:
Luke A. Pattison, Cintya Lopez-Lopez, Stephen Vanner, Daniel P. Poole, Dane D. Jensen, Brian L. Schmidt, Nestor N. Jiménez-Vargas, Nigel W. Bunnett, Tina Marie Lieu, Josue Obed Jaramillo, Peishen Zhao, Rocco Latorre
Publikováno v:
J Biol Chem
Proteases sustain hyperexcitability and pain by cleaving protease-activated receptor-2 (PAR(2)) on nociceptors through distinct mechanisms. Whereas trypsin induces PAR(2) coupling to Gα(q), Gα(s), and β-arrestins, cathepsin-S (CS) and neutrophil e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c4638576477fc8a1c3a05d9586f88c9
https://pubmed.ncbi.nlm.nih.gov/31142616
https://pubmed.ncbi.nlm.nih.gov/31142616
Autor:
Y Zhang, Jun Lu, Elena F. Verdu, Michael Beyak, C Shimbori, Stephen M. Collins, Stephanie Vanner, P Bercik, J Sessenwein, Alan E. Lomax, Marc Pigrau, G De Palma, Josue Jaramillo-Polanco, Yang Yu, David E. Reed, Cintya Lopez-Lopez, Nestor N. Jiménez-Vargas
Publikováno v:
Brain, Behavior, and Immunity. 76:e15-e16
Gut immune system, microbiota and diet appear to play important roles in irritable bowel syndrome (IBS). Increased levels of colonic mast cell (MC) located in close proximity to mucosal nerves were reported in IBS patients, correlating with increased
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b8681fa6c8797f1463d6bb35192e2a7
https://doi.org/10.1016/j.bbi.2018.11.220
https://doi.org/10.1016/j.bbi.2018.11.220