Zobrazeno 1 - 10
of 173
pro vyhledávání: '"Cintia S, De Paiva"'
Autor:
Jehan Alam, Ebru Yaman, Gerda Cristal Villalba Silva, Rui Chen, Cintia S. de Paiva, Mary Ann Stepp, Stephen C. Pflugfelder
Publikováno v:
Frontiers in Medicine, Vol 11 (2024)
BackgroundDry eye causes corneal inflammation, epitheliopathy and sensorineural changes. This study evaluates the hypothesis that dry eye alters the percentages and transcriptional profiles of immune cell populations in the cornea.MethodsDesiccating
Externí odkaz:
https://doaj.org/article/c8e026646a93472e9ccdb513fbe761c9
Autor:
Alexia Vereertbrugghen, Manuela Pizzano, Florencia Sabbione, Irene Angelica Keitelman, Carolina Maiumi Shiromizu, Douglas Vera Aguilar, Federico Fuentes, Cintia S. de Paiva, Mirta Giordano, Analía Trevani, Jeremías G. Galletti
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-23 (2023)
Abstract Proper sight is not possible without a smooth, transparent cornea, which is highly exposed to environmental threats. The abundant corneal nerves are interspersed with epithelial cells in the anterior corneal surface and are instrumental to c
Externí odkaz:
https://doaj.org/article/113ff38f70394d8493be549cd19919df
Autor:
Timon Ax, Bergita Ganse, Fabian N. Fries, Nóra Szentmáry, Cintia S. de Paiva, Francesc March de Ribot, Slade O. Jensen, Berthold Seitz, Thomas J. Millar
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Long-duration spaceflight can have adverse effects on human health. One of the most common ocular conditions experienced by astronauts is dry eye disease (DED). Symptoms of DED include feelings of eye irritation, eye strain, foreign body sensation an
Externí odkaz:
https://doaj.org/article/8d4af845e17c4af584c97c7a03bb91e5
Autor:
Xin Chen, Na Lin, Jin-Miao Li, Haixia Liu, Anmar Abu-Romman, Ebru Yaman, Fang Bian, Cintia S. de Paiva, Stephen C. Pflugfelder, De-Quan Li
Publikováno v:
Pharmaceutics, Vol 16, Iss 2, p 236 (2024)
Ectoine, a novel natural osmoprotectant, protects bacteria living in extreme environments. This study aimed to explore the therapeutic effect of ectoine for dry eye disease. An experimental dry eye model was created in C57BL/6 mice exposed to desicca
Externí odkaz:
https://doaj.org/article/ad818e3812ca4ed39de3fc488946258a
Autor:
Olivier Mauduit, Vanessa Delcroix, Takeshi Umazume, Cintia S. de Paiva, Darlene A. Dartt, Helen P. Makarenkova
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The lacrimal gland (LG) is an exocrine gland that produces the watery part of the tear film that lubricates the ocular surface. Chronic inflammation, such as Sjögren’s syndrome (SS), is one of the leading causes of aqueous-deficiency dry eye (ADDE
Externí odkaz:
https://doaj.org/article/3cac39adf1784d7b849280090c885268
Publikováno v:
Frontiers in Medicine, Vol 9 (2022)
Nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and neurotrophin3 (NT-3) bind to tyrosine kinase (Trk) receptors, TrkA, TrkB, and TrkC, respectively. This study investigated the efficacy of novel molecule agonists of Trk receptor
Externí odkaz:
https://doaj.org/article/15ab6fe43e224861973a1164b3a8ff7d
Autor:
Vanessa Delcroix, Olivier Mauduit, Hyun Soo Lee, Anastasiia Ivanova, Takeshi Umazume, Sarah M. Knox, Cintia S. de Paiva, Darlene A. Dartt, Helen P. Makarenkova
Publikováno v:
Cells, Vol 12, Iss 10, p 1435 (2023)
The lacrimal gland (LG) secretes aqueous tears. Previous studies have provided insights into the cell lineage relationships during tissue morphogenesis. However, little is known about the cell types composing the adult LG and their progenitors. Using
Externí odkaz:
https://doaj.org/article/454ea9d24e474bd9ae56b4399122086b
Autor:
Kaitlin K. Scholand, Alexis F. Mack, Gary U. Guzman, Michael E. Maniskas, Ritu Sampige, Gowthaman Govindarajan, Louise D. McCullough, Cintia S. de Paiva
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 5, p 4897 (2023)
Aging is associated with inflammation and oxidative stress in the lacrimal gland (LG). We investigated if heterochronic parabiosis of mice could modulate age-related LG alterations. In both males and females, there were significant increases in total
Externí odkaz:
https://doaj.org/article/a5456e1a65904acfbfd5cfe92fae86cd
Autor:
Vanessa Delcroix, Olivier Mauduit, Menglu Yang, Amrita Srivastava, Takeshi Umazume, Cintia S. de Paiva, Valery I. Shestopalov, Darlene A. Dartt, Helen P. Makarenkova
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 5, p 4309 (2023)
Lacrimal gland inflammation triggers dry eye disease through impaired tear secretion by the epithelium. As aberrant inflammasome activation occurs in autoimmune disorders including Sjögren’s syndrome, we analyzed the inflammasome pathway during ac
Externí odkaz:
https://doaj.org/article/6dc35ac6b0b24689b2f7ad023bb77f03
Autor:
Laura Schaefer, Claudia M. Trujillo-Vargas, Firas S. Midani, Stephen C. Pflugfelder, Robert A. Britton, Cintia S. de Paiva
Publikováno v:
Frontiers in Medicine, Vol 9 (2022)
Sjögren syndrome (SS) is an autoimmune inflammatory disorder characterized by secretory dysfunction in the eye and mouth; in the eye, this results in tear film instability, reduced tear production, and corneal barrier disruption. A growing number of
Externí odkaz:
https://doaj.org/article/82f81fe5100840b3a77b5388b138b2a0