Tumour necrosis factor -308 and -238 promoter polymorphisms are predictors of a null virological response in the treatment of Brazilian hepatitis C patients

Autor: Tarciana Grandi, Cláudia Maria Dornelles da Silva, Karine Medeiros Amaral, Paulo Dornelles Picon, Cintia Costi, Nicole Nascimento da Fré, Marilu Fiegenbaum, Tatiana Schäffer Gregianini, Christian Niel, Maria Lucia Rosa Rossetti

Publikováno v: Memorias do Instituto Oswaldo Cruz, Vol 109, Iss 3, Pp 345-351 (2014)

Certain host single nucleotide polymorphisms (SNPs) affect the likelihood of a sustained virological response (SVR) to treatment in subjects infected with hepatitis C virus (HCV). SNPs in the promoters of interleukin (IL)-10 (-1082 A/G, rs1800896), m

Externí odkaz: https://doaj.org/article/64024f1f51414b7f80329e57114a8358

High proportion of hepatitis C virus genotypes 1 and 3 in a large cohort of patients from Southern Brazil

Autor: Cláudia Maria Dornelles da Silva, Cintia Costi, Luciano Percival Krug, Ana Beatris Ramos, Tarciana Grandi, Vitório Luiz Gandolfi, Maria Elizabeth Menezes, Maristela Ocampos, Christian Niel, Maria Lucia Rosa Rossetti

Publikováno v: Memorias do Instituto Oswaldo Cruz, Vol 102, Iss 7, Pp 867-870 (2007)

Hepatitis C virus (HCV) isolates have been divided into six genotypes (1 to 6). The duration of hepatitis C standard treatment is 48 weeks for patients infected with HCV genotype 1 vs 24 weeks for those infected with genotypes 2 and 3. A total of 154

Externí odkaz: https://doaj.org/article/68efc8b9527944cc9378049cb5776108

Optimization of one-step real-time PCR for the X-tail target of HCV as a diagnostic test

Autor: Franciéli Pedrotti Rozales, Fernada de-Paris, Alice Beatriz Mombach Pinheiro Machado, Cintia Costi, Afonso Luis Barth

Publikováno v: Clinical and Biomedical Research, Vol 34, Iss 2 (2014)

Infection with hepatitis C virus (HCV) is a global public health issue. The bloodborne nature of HCV transmission poses a substantial risk to healthcare workers, due to occupational exposure to needlestick injuries and blood and other body fluids con

Externí odkaz: https://doaj.org/article/356b298e69674c81ab9a65d506fa137e

Association between cytokine gene polymorphisms and outcome of hepatitis B virus infection in southern Brazil

Autor: Cintia Costi, Maria Lucia Rosa Rossetti, Tarciana Grandi, Márcia Susana Nunes Silva, Rodrigo Rodenbusch, Claudia Silva, Christian Niel, Rúbia Marília de Medeiros, Arlete Ferrari Rech Medeiros, Maria Laura Halon, Carolina de Souza Gusatti

Publikováno v: Journal of Medical Virology. 88:1759-1766

A number of studies have demonstrated associations between cytokine gene polymorphisms and outcome of hepatitis B virus (HBV) infection. However, no general consensus has been reached, possibly due to differences between ethnic groups. In this study,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e101b929f595116220def827946a2508
https://doi.org/10.1002/jmv.24518

Response to treatment in Brazilian patients with chronic hepatitis C is associated with a single-nucleotide polymorphism near the interleukin-28B gene

Autor: Paulo Dornelles Picon, Christian Niel, Cintia Costi, Nicole Nascimento da Fré, Marilu Fiegenbaum, Tarciana Grandi, Karine Medeiros Amaral, Maria Lucia Rosa Rossetti, Cláudia Maria Dornelles da Silva

Publikováno v: Memórias do Instituto Oswaldo Cruz., Vol 108, Iss 1, Pp 48-53 (2013)
Repositório Institucional da UFRGS
Universidade Federal do Rio Grande do Sul (UFRGS)
instacron:UFRGS
Memórias do Instituto Oswaldo Cruz
Memórias do Instituto Oswaldo Cruz, Volume: 108, Issue: 1, Pages: 48-53, Published: FEB 2013
Marilu Fiegenbaum

A single-nucleotide polymorphism (SNP) upstream of interleukin (IL)28B was recently identified as an important predictor of the outcome of chronic hepatitis C patients treated with pegylated interferon plus ribavirin (PEG-IFN/ RBV). The aim of this s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::455827a36c24b3d6e60dd9a18633d72d
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762013000100008