Dosing and Re-Administration of Lentiviral Vector for In Vivo Gene Therapy in Rhesus Monkeys and ADA-Deficient Mice

Autor: Donald B. Kohn, Xiangyang Jin, Michael L. Kaufman, Alice F. Tarantal, Michele L. Martinez, Cinnamon L Hardee, Charles C. Lee, Krista M. Chun, Denise A. Carbonaro-Sarracino, Stephen Wandro, Danielle N. Clark, Colin Koziol, Xiaoyan Wang

Publikováno v: Molecular Therapy: Methods & Clinical Development, Vol 16, Iss, Pp 78-93 (2020)

Adenosine deaminase (ADA)-deficient mice and healthy rhesus monkeys were studied to determine the impact of age at treatment, vector dosage, dosing schedule, repeat administration, biodistribution, and immunogenicity after systemic delivery of lentiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4c5aa4f0fd316c27c67643f466573c2
http://www.sciencedirect.com/science/article/pii/S2329050119301299

Dosing and Re-Administration of Lentiviral Vector for

Autor: Denise A, Carbonaro-Sarracino, Alice F, Tarantal, C Chang I, Lee, Michael L, Kaufman, Stephen, Wandro, Xiangyang, Jin, Michele, Martinez, Danielle N, Clark, Krista, Chun, Colin, Koziol, Cinnamon L, Hardee, Xiaoyan, Wang, Donald B, Kohn

Publikováno v: Molecular Therapy. Methods & Clinical Development

Adenosine deaminase (ADA)-deficient mice and healthy rhesus monkeys were studied to determine the impact of age at treatment, vector dosage, dosing schedule, repeat administration, biodistribution, and immunogenicity after systemic delivery of lentiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a24d89610d855687551d4b5bbb38efd9
https://pubmed.ncbi.nlm.nih.gov/31871959

Modification of Hematopoietic Stem/Progenitor Cells with CD19-Specific Chimeric Antigen Receptors as a Novel Approach for Cancer Immunotherapy

Autor: Jennifer Wherley, Andy Tu, Irena Tremcinska, Donald B. Kohn, Satiro N. De Oliveira, Christine Ryan, David Elashoff, Cinnamon L Hardee, Laurence J.N. Cooper, Francesca Giannoni, Roger P. Hollis, Arineh Sahaghian, Tristan Grogan, Behrod Katebian

Publikováno v: De Oliveira, Satiro N; Ryan, Christine; Giannoni, Francesca; Hardee, Cinnamon L; Tremcinska, Irena; Katebian, Behrod; et al.(2013). Modification of hematopoietic stem/progenitor cells with CD19-specific chimeric antigen receptors as a novel approach for cancer immunotherapy.. Human gene therapy, 24(10), 824-839. UCLA: Retrieved from: http://www.escholarship.org/uc/item/7rj3w050

Chimeric antigen receptors (CARs) against CD19 have been shown to direct T-cells to specifically target B-lineage malignant cells in animal models and clinical trials, with efficient tumor cell lysis. However, in some cases, there has been insufficie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d50c7b9bda7a57f3377d29c367946bf
https://doi.org/10.1089/hum.2012.202

CD4+CD25− T Cells Transduced to Express MHC Class I-Restricted Epitope-Specific TCR Synthesize Th1 Cytokines and Exhibit MHC Class I-Restricted Cytolytic Effector Function in a Human Melanoma Model

Autor: James S. Economou, Begoña Comin-Anduix, David Baltimore, Roger P. Hollis, Haiguang Yang, Antoni Ribas, David I. Dorsky, Nitya G. Chakraborty, Donald B. Kohn, Swagatam Ray, Shikhar Mehrotra, Richard C. Koya, Pin Wang, Arvind Chhabra, Cinnamon L Hardee, Raja Das, Bijay Mukherji, Lili Yang

Publikováno v: The Journal of Immunology. 181:1063-1070

Cytolytic T cell-centric active specific and adoptive immunotherapeutic approaches might benefit from the simultaneous engagement of CD4+ T cells. Considering the difficulties in simultaneously engaging CD4+ and CD8+ T cells in tumor immunotherapy, e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b26d08a792b8f7fd0985154abbb7433e
https://doi.org/10.4049/jimmunol.181.2.1063

Regulated expansion of human pancreatic beta-cells

Autor: Vahagn Nikolian, Kit L. Shaw, Dianne C. Skelton, Tamas Alexy, Cinnamon L Hardee, Jean Park, Shundi Ge, Shantha Senadheera, Eszter Pais, Roger P. Hollis, Donald B. Kohn

Publikováno v: Molecular therapy : the journal of the American Society of Gene Therapy. 18(7)

Although pancreatic beta-cell transplantation may serve as a potential cure for diabetes mellitus (DM), limited donor tissue availability poses a major challenge. Thus, there is a great demand to find new sources for pancreatic beta-cells. Here, we p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa4fdc97cb6bea07110d6af9fd85e906
https://pubmed.ncbi.nlm.nih.gov/20389286