MCM8- and MCM9 Deficiencies Cause Lifelong Increased Hematopoietic DNA Damage Driving p53-Dependent Myeloid Tumors

Autor: Malik Lutzmann, Florence Bernex, Cindy da Costa de Jesus, Dana Hodroj, Caroline Marty, Isabelle Plo, William Vainchenker, Marie Tosolini, Luc Forichon, Caroline Bret, Sophie Queille, Candice Marchive, Jean-Sébastien Hoffmann, Marcel Méchali

Publikováno v: Cell Reports, Vol 28, Iss 11, Pp 2851-2865.e4 (2019)

Summary: Hematopoiesis is particularly sensitive to DNA damage. Myeloid tumor incidence increases in patients with DNA repair defects and after chemotherapy. It is not known why hematopoietic cells are highly vulnerable to DNA damage. Addressing this

Externí odkaz: https://doaj.org/article/1b5c45032647429590e52fb8e732a408

Supplementary Figures 1 - 3, Table 1 from Triggering the TCR Developmental Checkpoint Activates a Therapeutically Targetable Tumor Suppressive Pathway in T-cell Leukemia

Autor: Vahid Asnafi, Jacques Ghysdael, Elizabeth Macintyre, Olivier Hermine, David-Alexandre Gross, Lucienne Chatenoud, Salvatore Spicuglia, Hervé Dombret, Norbert Ifrah, Françoise Pflumio, Els Verhoeyen, François-Loïc Cosset, Michael Dussiot, Melania Tesio, Ludovic Lhermitte, Cindy Da Costa de Jesus, Mohamed Belhocine, Benedetta Zaniboni, Francesca Rocchetti, Christine Tran Quang, Nuno R. dos Santos, Amélie Trinquand

Supplementary Figure 1. Anti-CD3 stimulation of primary human T-ALLs. Supplementary Figure 2. TCR stimulation by in vivo administration of agonistic monoclonal antibody in a preventive setting inhibits human TCR+ T-ALL development. Supplementary Figu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fc88f82dad967c7efadb3786c3315ac
https://doi.org/10.1158/2159-8290.22531317

Triggering the TCR Developmental Checkpoint Activates a Therapeutically Targetable Tumor Suppressive Pathway in T-cell Leukemia

Autor: David-Alexandre Gross, Melania Tesio, Amélie Trinquand, Mohamed Belhocine, Hervé Dombret, Norbert Ifrah, Benedetta Zaniboni, Lucienne Chatenoud, Vahid Asnafi, Francesca Rocchetti, François-Loïc Cosset, Nuno R. dos Santos, Christine Tran Quang, Ludovic Lhermitte, Jacques Ghysdael, Elizabeth Macintyre, Michael Dussiot, Françoise Pflumio, Olivier Hermine, Els Verhoeyen, Cindy Da Costa de Jesus, Salvatore Spicuglia

Publikováno v: Cancer Discovery
Cancer Discovery, 2016, 6 (9), pp.972-985. ⟨10.1158/2159-8290.CD-15-0675⟩
Cancer Discovery, 2016, 6 (9), pp.972-985. 〈10.1158/2159-8290.CD-15-0675〉
Cancer Discovery, American Association for Cancer Research, 2016, 6 (9), pp.972-985. ⟨10.1158/2159-8290.CD-15-0675⟩
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
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Cancer onset and progression involves the accumulation of multiple oncogenic hits, which are thought to dominate or bypass the physiologic regulatory mechanisms in tissue development and homeostasis. We demonstrate in T-cell acute lymphoblastic leuke

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c59201c5ea87dd18b2ba268c4e4413e
https://amu.hal.science/hal-01460133