Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Cindy Woodland"'
Publikováno v:
Toxics, Vol 8, Iss 4, p 126 (2020)
The movement away from mammalian testing of potential toxicants and new chemical entities has primarily led to cell line testing and protein-based assays. However, these assays may not yet be sufficient to properly characterize the toxic potential of
Externí odkaz:
https://doaj.org/article/cd7aa085e4f641eea0aa656f6f43ec6c
Publikováno v:
Toxicological Sciences. 190:133-145
Zebrafish larvae have classically been used as a high-throughput model with which to test both the bioactivity and toxicity of known and novel compounds, making them a promising whole organism New Approach Method in the context of the international m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8891c862a2ce466153ccf2be69a558d4
https://doi.org/10.1093/toxsci/kfac102
https://doi.org/10.1093/toxsci/kfac102
Autor:
Sarkar, Moumita1,2 moumita.sarkar@sickkids.ca, C., Cindy Woodland1,3 c.woodland@utoronto.ca, Koren, Gideon1,2,3 gkoren@sickkids.ca, Einarson, Adrienne R. N.1 einarson@sickkids.ca
Publikováno v:
BMC Pregnancy & Childbirth. 2006, Vol. 6, p18-5. 5p. 2 Charts.
Publikováno v:
British Journal of Pharmacology. 153:1364-1372
Background and purpose: Ifosfamide nephrotoxicity is a serious adverse effect for children undergoing cancer chemotherapy. Our recent in vitro studies have shown that the antioxidant N-acetylcysteine (NAC), which is used extensively as an antidote fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f40f6e7e9cace257c18749a23d216bb
https://doi.org/10.1038/bjp.2008.15
https://doi.org/10.1038/bjp.2008.15
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 81:800-805
Multidrug resistance in cancer chemotherapy frequently correlates with overexpression of the P-glycoprotein drug transporter. Attempts to reverse P-glycoprotein-mediated multidrug resistance with racemic verapamil or its less toxic (R)-enantiomer hav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8670ce89cbe588f325bde3d6bff09d65
https://doi.org/10.1139/y03-073
https://doi.org/10.1139/y03-073
Publikováno v:
Journal of Clinical Pharmacology. 43:743-750
Drug interactions are a common source of drug-induced toxicity. For drugs with narrow therapeutic windows, such as digoxin, an understanding of the potential mechanisms by which drugs might interact is essential to clinical practice. This article des
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e6ec9f92aad16dfb1c945dfeebf6d50
https://doi.org/10.1177/0091270003043007008
https://doi.org/10.1177/0091270003043007008
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 88:177
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c5f44e8c3df0c12a2c5e793bb9f35e8
https://doi.org/10.1016/j.vascn.2017.09.033
https://doi.org/10.1016/j.vascn.2017.09.033
Publikováno v:
Pediatric Nephrology. 16:1153-1158
Ifosfamide has been in use as an effective antineoplastic agent for solid tumors in both children and adults since the late 1960s. Although some adverse effects (e.g. hemorrhagic cystitis) can be overcome by the co-administration of 2-mercaptoethanes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6721fa094e25fe415a705f18707fd77
https://doi.org/10.1007/s004670100053
https://doi.org/10.1007/s004670100053
Publikováno v:
American Journal of Physiology-Renal Physiology. 277:F84-F96
P-glycoprotein (P-gp) on the apical membranes of epithelial cells is known as a drug efflux pump. However, unclear is its integral quantitative role in the overall epithelial drug transfer, which also involves distinct diffusion processes in parallel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aadb01bef881c030ce7408932b69f011
https://doi.org/10.1152/ajprenal.1999.277.1.f84
https://doi.org/10.1152/ajprenal.1999.277.1.f84
Publikováno v:
Therapeutic Drug Monitoring. 20:134-138
Digoxin-drug interactions are relatively common causes of digitalis toxicity. Recently, the clinical importance of the renal tubular secretion of digoxin has been proven by documenting drug interactions at this level. The authors describe a model usi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62ec2d7117f774070382f262df154236
https://doi.org/10.1097/00007691-199804000-00002
https://doi.org/10.1097/00007691-199804000-00002