Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Cindy Tzu-Ling Huang"'
Autor:
Nina M. Dräger, Sydney M. Sattler, Cindy Tzu-Ling Huang, Olivia M. Teter, Kun Leng, Sayed Hadi Hashemi, Jason Hong, Giovanni Aviles, Claire D. Clelland, Lihong Zhan, Joe C. Udeochu, Lay Kodama, Andrew B. Singleton, Mike A. Nalls, Justin Ichida, Michael E. Ward, Faraz Faghri, Li Gan, Martin Kampmann
Publikováno v:
Nature neuroscience, vol 25, iss 9
Microglia are emerging as key drivers of neurological diseases. However, we lack a systematic understanding of the underlying mechanisms. Here, we present a screening platform to systematically elucidate functional consequences of genetic perturbatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dacd0dd4f4f4a2c727da14efed73b6fb
https://escholarship.org/uc/item/00b6v7cg
https://escholarship.org/uc/item/00b6v7cg
Autor:
Jianfeng Lu, Huisheng Liu, Cindy Tzu-Ling Huang, Hong Chen, Zhongwei Du, Yan Liu, Mohammad Amin Sherafat, Su-Chun Zhang
Publikováno v:
Cell Reports, Vol 3, Iss 5, Pp 1580-1591 (2013)
Postnatal and adult human and monkey fibroblasts were infected with Sendai virus containing the Yamanaka factors for 24 hr, then they were cultured in a chemically defined medium containing leukemia inhibitory factor (LIF), transforming growth factor
Externí odkaz:
https://doaj.org/article/962dd1ab614b48409e0fb1e75f55810d
Autor:
Nina M, Dräger, Sydney M, Sattler, Cindy Tzu-Ling, Huang, Olivia M, Teter, Kun, Leng, Sayed Hadi, Hashemi, Jason, Hong, Giovanni, Aviles, Claire D, Clelland, Lihong, Zhan, Joe C, Udeochu, Lay, Kodama, Andrew B, Singleton, Mike A, Nalls, Justin, Ichida, Michael E, Ward, Faraz, Faghri, Li, Gan, Martin, Kampmann
Publikováno v:
Nature neuroscience. 25(9)
Microglia are emerging as key drivers of neurological diseases. However, we lack a systematic understanding of the underlying mechanisms. Here, we present a screening platform to systematically elucidate functional consequences of genetic perturbatio
Autor:
Ke Xu, Erik D. Roberson, Rui Yan, Shiaoching Gong, Celeste M. Karch, Kelly M. Montgomery, Kenneth S. Kosik, Manni He, Cindy Tzu-Ling Huang, Rebecca Freilich, Carolina M. Camargo, Sue-Ann Mok, Tara E. Tracy, Li Fan, Peter Dongmin Sohn, Justin Baik, Taylor Arhar, Li Gan, Jason E. Gestwicki
Publikováno v:
Neuron, vol 104, iss 3
Dysregulation of neuronal excitability underlies the pathogenesis of tauopathies, including frontotemporal dementia (FTD) with tau inclusions. A majority of FTD-causing tau mutations are located in the microtubule-binding domain, but how these mutati
Autor:
Su-Chun Zhang, Yunlong Tao, Jeffrey R. Jones, Jason P. Weick, Lucas Fowler, Cindy Tzu-Ling Huang, Jianfeng Lu
Publikováno v:
Scientific Reports
The process of neuroepithelial differentiation from human pluripotent stem cells (PSCs) resembles in vivo neuroectoderm induction in the temporal course, morphogenesis, and biochemical changes. This in vitro model is therefore well-suited to reveal p
Autor:
Jing Chen, Gennadiy I. Bondarenko, Jin Li, Jiajie Xi, Su-Chun Zhang, Timothy M. LaVaute, Zhong Wei Du, Melvin Ayala, Thaddeus G. Golos, Ying Yang, Cindy Tzu-Ling Huang, Xiaoqing Zhang, Xue-Jun Li, Matthew T. Pankratz, Ying Jin
Publikováno v:
Cell Stem Cell. 7(1):90-100
The transcriptional regulation of neuroectoderm (NE) specification is unknown. Here we show that Pax6 is uniformly expressed in early NE cells of human fetuses and those differentiated from human embryonic stem cells (hESCs). This is in contrast to t
Autor:
Jianfeng Lu, Mohammad Amin Sherafat, Cindy Tzu-Ling Huang, Huisheng Liu, Su-Chun Zhang, Ling Hao, Jeffrey P. Jones, Xuefei Zhong, Lingjun Li, Melvin Ayala
Publikováno v:
Nature biotechnology. 34(1)
Serotonin neurons located in the raphe nucleus of the hindbrain have crucial roles in regulating brain functions and have been implicated in various psychiatric disorders. Yet functional human serotonin neurons are not available for in vitro studies.
Autor:
Kun Qian, Zhongwei Du, Xiaofen Zhong, Frank Fan, Hong Chen, Su-Chun Zhang, Cindy Tzu-Ling Huang, Huisheng Liu, Jianfeng Lu
Publikováno v:
Nature communications
SUMMARY Human pluripotent stem cells (hPSCs) have opened new opportunities for understanding human development, modeling disease processes and developing new therapeutics. However, these applications are hindered by low-efficiency and heterogeneity o
Autor:
Hong Chen, Jianfeng Lu, Huisheng Liu, Zhong-Wei Du, Cindy Tzu-Ling Huang, Mohammad Amin Sherafat, Su-Chun Zhang, Yan Liu
Publikováno v:
Cell Reports, Vol 3, Iss 5, Pp 1580-1591 (2013)
SummaryPostnatal and adult human and monkey fibroblasts were infected with Sendai virus containing the Yamanaka factors for 24 hr, then they were cultured in a chemically defined medium containing leukemia inhibitory factor (LIF), transforming growth
Fibroblast growth factor (FGF) signaling and PAX6 transcription are required for neuroectoderm specification of human embryonic stem cells (hESCs). In this study, we asked how FGF signaling leads to PAX6 transcription and neuroectoderm specification
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a761b119f81e6829a7883e0860f5dc4
https://europepmc.org/articles/PMC3229919/
https://europepmc.org/articles/PMC3229919/