Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Cindy Starbuck"'
Autor:
Shane T. Grosser, Angela Spartalis, John Higgins, George Zhou, Gabriel C. Graffius, Cindy Starbuck, Busolo Wabuyele, Aaron Moment, Paul Fernandez, Lei Sun, Ganeshwar Prasad
Publikováno v:
Organic Process Research & Development. 20:653-660
The transamination-chemistry-based process for sitagliptin is a through-process, which challenges the crystallization of the active pharmaceutical ingredient (API) in a batch stream composed of multiple components. Risk-assessment-based design of exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::703d72ed10828e859636a769360d9565
https://doi.org/10.1021/acs.oprd.5b00409
https://doi.org/10.1021/acs.oprd.5b00409
Autor:
Hsien-Hsin Tung, Richard D. Braatz, Omar Davidson, Cindy Starbuck, Xing Yi Woo, Effendi Rusli, and Zhihong Ge, Mitsuko Fujiwara, George Zhou
Publikováno v:
Crystal Growth & Design. 6:892-898
Recent advances in in situ measurement technology and automation of batch crystallizers have enabled the development of batch crystallization recipes in which the desired supersaturation profile is followed by feedback control. This paper describes a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::72e61a8c917f5bb54ef733bf5110002b
https://doi.org/10.1021/cg0504049
https://doi.org/10.1021/cg0504049
Autor:
George Zhou, Paul Fernandez, Christopher M. Lindemann, Lawrence Wai, Zhihong Ge, Angela Spartalis, Cindy Starbuck, Jian Wang
Publikováno v:
Crystal Growth & Design. 2:515-522
In situ Raman spectroscopy was used to determine the rate of polymorph turnover for MK-A, a multipolymorphic compound in development at Merck Research Laboratories. The known crystal forms of MK-A include four anhydrous polymorphs, two hydrates, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b010b63c945a41678e51072f04696eaa
https://doi.org/10.1021/cg025559k
https://doi.org/10.1021/cg025559k
Autor:
Patrick J. Marsac, Robert F. Meyer, Graciela Terife, Seth P. Forster, Chad D. Brown, James DiNunzio, Matthew S. Lamm, Brandye Smith-Goettler, Luke Schenck, Cindy Starbuck, Craig A. McKelvey, Michael Eglesia, Gregory M. Troup, Michael Lowinger
Publikováno v:
Advances in Delivery Science and Technology ISBN: 9781493915972
The advantages provided by melt extrusion over other amorphous dispersion manufacturing technologies make it uniquely suited for commercial applications. The proven scalability of the technology combined with the modular nature provides unmatched ver
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c5ea5ee533b5cc0be76da8b8b3d87b49
https://doi.org/10.1007/978-1-4939-1598-9_7
https://doi.org/10.1007/978-1-4939-1598-9_7
Autor:
Cindy Starbuck, Patrick J. Marsac, Robert F. Meyer, Chad D. Brown, Gregory M. Troup, Brandye Smith-Goettler, Craig A. McKelvey, Seth P. Forster, Luke Schenck, Michael Lowinger, Michael Eglesia, Graciela Terife, James DiNunzio, Matthew S. Lamm
Publikováno v:
Advances in Delivery Science and Technology ISBN: 9781493915972
Melt extrusion is a robust and efficient manufacturing platform that can be utilized for the production of amorphous dispersions. The development of these systems requires careful design of both formulation and process under a structured approach to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e0aba6ff7590e05e6685f1a06ec85ba
https://doi.org/10.1007/978-1-4939-1598-9_6
https://doi.org/10.1007/978-1-4939-1598-9_6
Publikováno v:
Biotechnology Progress. 8:132-143
We apply a mathematical model for receptor-mediated cell uptake and processing of epidermal growth factor (EGF) to analyze and predict proliferation responses to fibroblastic cells transfected with various forms of the EGF receptor (EGFR) to EGF. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fde6dcca3ad3ab4e580cf5f87532ac1
https://doi.org/10.1021/bp00014a007
https://doi.org/10.1021/bp00014a007
Publikováno v:
Journal of cellular biochemistry. 51(3)
The association/dissociation binding kinetics of 125I-labeled mouse epidermal growth factor (EGF) to receptors on human fibroblast cells in monolayer culture have been measured at 4 degrees C as a function of extracellular pH from pH 5-9. At pH 8, st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bad62becd388c64aeed47043c114f64
https://pubmed.ncbi.nlm.nih.gov/8501133
https://pubmed.ncbi.nlm.nih.gov/8501133
Publikováno v:
Journal of Biological Chemistry. 264:17838-17844
The binding kinetics of 125I-labeled mouse epidermal growth factor (EGF) to receptors on human fibroblast cells in monolayer culture were measured at 4 degrees C. Initial binding rates as a function of hormone concentration allowed estimation of simp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e5a23bfec03ec0b279ad52624ad008a8
https://doi.org/10.1016/s0021-9258(19)84649-5
https://doi.org/10.1016/s0021-9258(19)84649-5