Repurposing of auranofin and honokiol as antifungals against Scedosporium species and the related fungus Lomentospora prolificans

Autor: Hajar Yaakoub, Cindy Staerck, Sara Mina, Charlotte Godon, Maxime Fleury, Jean-Philippe Bouchara, Alphonse Calenda

Publikováno v: Virulence, Vol 12, Iss 1, Pp 1076-1090 (2021)

The slowing-down de novo drug-discovery emphasized the importance of repurposing old drugs. This is particularly true when combating infections caused by therapy-refractory microorganisms, such as Scedosporium species and Lomentospora prolificans. Re

Externí odkaz: https://doaj.org/article/5b35fc40c3d3443aa7f8828a4bfb523e

The Glycosylphosphatidylinositol-Anchored Superoxide Dismutase of Scedosporium apiospermum Protects the Conidia from Oxidative Stress

Autor: Cindy Staerck, Hajar Yaakoub, Patrick Vandeputte, Julie Tabiasco, Charlotte Godon, Amandine Gastebois, Sandrine Giraud, Thomas Guillemette, Alphonse Calenda, Yves Delneste, Maxime Fleury, Jean-Philippe Bouchara

Publikováno v: Journal of Fungi, Vol 7, Iss 7, p 575 (2021)

Scedosporium species are common fungal pathogens in patients with cystic fibrosis (CF). To colonize the CF lungs, fungi must cope with the host immune response, especially the reactive oxygen species (ROS) released by phagocytic cells. To this aim, p

Externí odkaz: https://doaj.org/article/534f2cfbfe114dd0a4d6ccf23959c72f

Characterisation of the manganese superoxide dismutase of Enterococcus faecium

Autor: Aurélie Budin-Verneuil, Eliette Riboulet-Bisson, Axel Hartke, Valentin Wasselin, Cindy Staerck, Abdellah Benachour, Loïc Léger, Isabelle Rincé

Publikováno v: Research in microbiology. 172(6)

The manganese superoxide dismutase (SodA) of E. faecium strain AUS0004 has been characterised. It is most closely related to Enterococcus hirae , Enterococcus durans , Enterococcus villorium, and Enterococcus mundtii with 100%, 91,55%, 90,85%, and 90

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13a139166fcf46f0e53255f9fc89c403
https://pubmed.ncbi.nlm.nih.gov/34474124

Repurposing of auranofin and honokiol as antifungals against Scedosporium species and the related fungus Lomentospora prolificans

Autor: Jean-Philippe Bouchara, Sara Mina, Cindy Staerck, Alphonse Calenda, Hajar Yaakoub, Maxime Fleury, Charlotte Godon

Publikováno v: Virulence
Virulence, Taylor & Francis, 2021, 12 (1), pp.1076-1090. ⟨10.1080/21505594.2021.1909266⟩
article-version (VoR) Version of Record
Virulence, Vol 12, Iss 1, Pp 1076-1090 (2021)

The slowing-down de novo drug-discovery emphasized the importance of repurposing old drugs. This is particularly true when combating infections caused by therapy-refractory microorganisms, such as Scedosporium species and Lomentospora prolificans. Re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eae0b8fd616cffd9f7a7c03b4478da89

Transcriptional profiling of Scedosporium apiospermum enzymatic antioxidant gene battery unravels the involvement of thioredoxin reductases against chemical and phagocytic cells oxidative stress

Autor: Charlotte Godon, Jean-Philippe Bouchara, Yves Delneste, Julie Tabiasco, Cindy Staerck, Maxime Fleury

Publikováno v: Medical Mycology
Medical Mycology, Oxford University Press, 2018, Epub ahead of print. 〈10.1093/mmy/myy033〉
Medical Mycology, Oxford University Press, 2019, 57, pp.363-373. ⟨10.1093/mmy/myy033⟩
Medical Mycology, 2019, 57, pp.363-373. ⟨10.1093/mmy/myy033⟩

International audience; Scedosporium species rank the second, after Aspergillus fumigatus, among the filamentous fungi colonizing the airways of patients with cystic fibrosis (CF). Development of microorganisms in the respiratory tract depends on the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b891780897938482fd539e2213976b8
http://www.hal.inserm.fr/inserm-01814253