Výsledky vyhledávání - "Cindy R. Moomaw"

Alteration in regulation of inflammatory response to influenza a virus and endotoxin in suckling rat pups: a potential relationship to sudden infant death syndrome

Autor: Jane Blood-Siegfried, Holly S. Lieder, Abraham Nyska, Kristen Geisenhoffer, Burton Shelton, Kelly Cobb, Dori R. Germolec, William Coombs, Cindy R. Moomaw

Publikováno v: FEMS Immunology and Medical Microbiology. 42:85-93

Data increasingly implicate a possible role of immune and inflammatory responses to infection in sudden infant death syndrome (SIDS). We have previously described a dual challenge model that results in pathology, organ damage, vascular collapse and u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55a41f0c66631bd5fb3caa8190992917
https://doi.org/10.1016/j.femsim.2004.06.004

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Chemical-specific alterations in ras, p53, and β-catenin genes in hemangiosarcomas from B6C3F1 mice exposed to o-nitrotoluene or riddelliine for 2 years

Autor: Natasha P. Clayton, June K. Dunnick, Po-Chuen Chan, Cindy R. Moomaw, Theodora R. Devereux, Robert C. Sills, T. V. Ton, Hue-Hua L. Hong

Publikováno v: Toxicology and Applied Pharmacology. 191:227-234

The most prominent neoplastic lesions in mice in the 2-year studies of o -nitrotoluene and riddelliine were hemangiosarcomas. Fifteen o -nitrotoluene-induced hemangiosarcomas of the skeletal muscle, subcutaneous tissue, and mesentery; 12 riddelliine-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34f52dcafe113cdc00f11f8d3e583181
https://doi.org/10.1016/s0041-008x(03)00165-0

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The Hepatic Endothelial Carcinogen Riddelliine Induces Endothelial Apoptosis, Mitosis, S Phase, and p53 and Hepatocytic Vascular Endothelial Growth Factor Expression after Short-Term Exposure

Autor: Abraham Nyska, David G. Allen, Connie A. Cummings, Shyamal D. Peddada, Carolyn F. Moyer, Cindy R. Moomaw, Po C. Chan, Julie F. Foley, David E. Malarkey, Robert R. Maronpot, Greg Travlos

Publikováno v: Toxicology and Applied Pharmacology. 184:153-164

Riddelliineis a naturally occurring pyrrolizidine alkaloid found in certain poisonous rangeland plants of the western United States. In National Toxicology Program 2-year studies, riddelliine induced high incidences of hemangiosarcoma in the liver of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ccc863f8e449db6d9c04206174bd768
https://doi.org/10.1006/taap.2002.9485

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Susceptibility of Cyclooxygenase-2-Deficient Mice to Pulmonary Fibrogenesis

Autor: Annette B. Rice, Jennifer L. Ingram, Alisha R. Sessoms, Daniel L. Morgan, Abraham Nyska, Patricia C. Chulada, Darryl C. Zeldin, Cindy R. Moomaw, Alyce Bradbury, Robert Langenbach, James C. Bonner

Publikováno v: The American Journal of Pathology. 161:459-470

The cyclooxygenase (COX)-2 enzyme has been implicated as an important mediator of pulmonary fibrosis. In this study, the lung fibrotic responses were investigated in COX-1 or COX-2-deficient (-/-) mice following vanadium pentoxide (V(2)O(5)) exposure

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ed27469a90f4d70ab9cf377f5391522
https://doi.org/10.1016/s0002-9440(10)64202-2

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Glutathione S-transferase Pi expression in forestomach carcinogenesis process induced by gavage-administered 2,4-hexadienal in the F344 rat

Autor: Abraham Nyska, Po C. Chan, Liat Lomnitski, Cindy R. Moomaw

Publikováno v: Archives of Toxicology. 75:618-624

2,4-Hexadienal (2,4-Hx), an unsaturated aldehyde formed by in vivo and in vitro peroxidation of unsaturated lipid induced, in National Toxicology Program (NTP) gavage studies of F344 rats, forestomach hyperplasia in 13-week and 2-year exposures and s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91c4c83384106ef9eb6110375ea0b585
https://doi.org/10.1007/s002040100278

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Unique Renal Tubule Changes Induced in Rats and Mice by the Peroxisome Proliferators 2,4-Dichlorophenoxyacetic Acid (2,4-D) and WY-14643

Autor: Joseph K. Haseman, Joel F. Mahler, Keisuke Ozaki, Matthew L. Nicolette, Abraham Nyska, Cindy R. Moomaw

Publikováno v: Toxicologic Pathology. 29:440-450

Peroxisome proliferators are non-mutagenic carcinogens in the liver of rodents, acting both as initiators and promoters. The National Toxicology Program (NTP) conducted a study of several peroxisome proliferators (PPs), including Wyeth (WY)-14643 as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1a9871af375b4cc0081d6e16939032f
https://doi.org/10.1080/01926230152499791

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Effects of iodine on inducible nitric oxide synthase and cyclooxygenase-2 expression in sulfur mustard-induced skin injury in guinea pigs

Autor: Abraham Nyska, Amnon Sintov, Cindy R. Moomaw, Berta Brodsky, Uri Wormser, Liat Lomnitski, Robert R. Maronpot

Publikováno v: Archives of Toxicology. 74:768-774

In a previous study we demonstrated the protective effect of topical iodine as postexposure treatment for sulfur mustard (SM) application. The iodine treatment results in significantly reduced inflammation and necrosis and increased epidermal hyperpl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8f8500ca7220be909c3de9d2df1984b6
https://doi.org/10.1007/s002040000199

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Mutations of ras Protooncogenes and p53 Tumor Suppressor Gene in Cardiac Hemangiosarcomas from B6C3F1 Mice Exposed to 1,3-Butadiene for 2 Years

Autor: Ronald L. Melnick, Robert C. Sills, Theodora R. Devereux, Cindy R. Moomaw, Gary A. Boorman, Hue-Hua L. Hong

Publikováno v: Toxicologic Pathology. 28:529-534

1,3-Butadiene is a multisite carcinogen in rodents. Incidences of cardiac hemangiosarcomas were significantly increased in male and female B6C3F1 mice that inhaled 1,3-butadiene (BD) for 2 years. Eleven BD-induced cardiac hemangiosarcomas were examin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7aba2e910b4253341ad0c3f89aa03ef7
https://doi.org/10.1177/019262330002800404

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Airway fibrosis in rats induced by vanadium pentoxide

Autor: Daniel L. Morgan, Cindy R. Moomaw, Annette B. Rice, James C. Bonner

Publikováno v: American Journal of Physiology-Lung Cellular and Molecular Physiology. 278:L209-L216

Vanadium pentoxide (V2O5) is a cause of occupational asthma and bronchitis. We previously reported that intratracheal instillation of rats with V2O5causes fibrosis of the lung parenchyma (J. C. Bonner, P. M. Lindroos, A. B. Rice, C. R. Moomaw, and D.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f527f6dd3ba642e0bdeaeca7a3cece83
https://doi.org/10.1152/ajplung.2000.278.1.l209

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Specific Inhibitors of Platelet-Derived Growth Factor or Epidermal Growth Factor Receptor Tyrosine Kinase Reduce Pulmonary Fibrosis in Rats

Autor: Annette B. Rice, Cindy R. Moomaw, Daniel L. Morgan, James C. Bonner

Publikováno v: The American Journal of Pathology. 155:213-221

The proliferation of myofibroblasts is a central feature of pulmonary fibrosis. In this study we have used tyrosine kinase inhibitors of the tyrphostin class to specifically block autophosphorylation of the platelet-derived growth factor receptor (PD

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::194177baad5aea70e744b9a0296eeb77
https://doi.org/10.1016/s0002-9440(10)65115-2

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