Výsledky vyhledávání - "Cindy Q, Xia"

Akademický článek

Immunogenicity assessment of AAV-based gene therapies: An IQ consortium industry white paper

Autor: Tong-yuan Yang, Manuela Braun, Wibke Lembke, Fraser McBlane, John Kamerud, Stephen DeWall, Edit Tarcsa, Xiaodong Fang, Lena Hofer, Uma Kavita, Vijay V. Upreti, Swati Gupta, LiNa Loo, Alison J. Johnson, Rakesh Kantilal Chandode, Kay-Gunnar Stubenrauch, Maya Vinzing, Cindy Q. Xia, Vibha Jawa

Publikováno v: Molecular Therapy: Methods & Clinical Development, Vol 26, Iss , Pp 471-494 (2022)

Immunogenicity has imposed a challenge to efficacy and safety evaluation of adeno-associated virus (AAV) vector-based gene therapies. Mild to severe adverse events observed in clinical development have been implicated with host immune responses again

Externí odkaz: https://doaj.org/article/1b85bb2274f44631a3d3b829f5704b0f

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Akademický článek

Recent advances in the translation of drug metabolism and pharmacokinetics science for drug discovery and development

Autor: Yurong Lai, Xiaoyan Chu, Li Di, Wei Gao, Yingying Guo, Xingrong Liu, Chuang Lu, Jialin Mao, Hong Shen, Huaping Tang, Cindy Q. Xia, Lei Zhang, Xinxin Ding

Publikováno v: Acta Pharmaceutica Sinica B, Vol 12, Iss 6, Pp 2751-2777 (2022)

Drug metabolism and pharmacokinetics (DMPK) is an important branch of pharmaceutical sciences. The nature of ADME (absorption, distribution, metabolism, excretion) and PK (pharmacokinetics) inquiries during drug discovery and development has evolved

Externí odkaz: https://doaj.org/article/ad5b8e44c4ee4e82a20397fba8e3e93f

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Akademický článek

Predicting Approximate Clinically Effective Doses in Oncology Using Preclinical Efficacy and Body Surface Area Conversion: A Retrospective Analysis

Autor: Robert J. Griffin, Ethan Avery, Cindy Q. Xia

Publikováno v: Frontiers in Pharmacology, Vol 13 (2022)

The correlation between efficacious doses in human tumor-xenograft mouse models and the human clinical doses of approved oncology agents was assessed using published preclinical data and recommended clinical doses. For 90 approved small molecule anti

Externí odkaz: https://doaj.org/article/9b32fdea2b774d79a27e4cd5f09dcf25

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Data from Preclinical Antitumor Activity and Biodistribution of a Novel Anti-GCC Antibody–Drug Conjugate in Patient-derived Xenografts

Guanylyl cyclase C (GCC) is a unique therapeutic target with expression restricted to the apical side of epithelial cell tight junctions thought to be only accessible by intravenously administered agents on malignant tissues where GCC expression is a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e7d56b0bf0e605a39ee70fc897c8b59
https://doi.org/10.1158/1535-7163.c.6542328.v1

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Supplementary Data: Figure S1-3 and Table S1-S5 from Preclinical Antitumor Activity and Biodistribution of a Novel Anti-GCC Antibody–Drug Conjugate in Patient-derived Xenografts

Supplemental Figure 1: heavy and light chain sequences for 5F9, the human IgG1 monoclonal antibody (mAb) targeting the extracellular domain of GCC as described previously Supplemental Figure 2: Characterization of TAK-164 and chKTI-DGN549 by A) SDS P

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fc671e1a3ed72f6591ec22f46838181
https://doi.org/10.1158/1535-7163.22519161.v1

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Sinusoidal Organic Anion-Transporting Polypeptide 1B1/1B3 and Bile Canalicular Multidrug Resistance-Associated Protein 2 Play an Essential Role in the Hepatobiliary Disposition of a Synthetic Cyclic Dinucleotide (STING Agonist)

Autor: Philip, Sandoval, Bei-Ching, Chuang, John K, Fallon, Philip C, Smith, Swapan K, Chowdhury, Robert J, Griffin, Cindy Q, Xia, Shinji, Iwasaki, Paresh P, Chothe

Publikováno v: The AAPS journal. 24(6)

The liver is central to the elimination of many drugs from the body involving multiple processes and understanding of these processes is important to quantitively assess hepatic clearance of drugs. The synthetic STING (STimulator of INterferon Genes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4a26f47579196577f58f52183c4d0089
https://pubmed.ncbi.nlm.nih.gov/36123502

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Preclinical Antitumor Activity and Biodistribution of a Novel Anti-GCC Antibody–Drug Conjugate in Patient-derived Xenografts

Publikováno v: Molecular Cancer Therapeutics. 19:2079-2088

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f36fad95085a4edda953eff31247a4c7
https://doi.org/10.1158/1535-7163.mct-19-1102

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Biotransformation Pathways and Metabolite Profiles of Oral [14C]Alisertib (MLN8237), an Investigational Aurora A Kinase Inhibitor, in Patients with Advanced Solid Tumors

Autor: Cindy Q. Xia, Sandeepraj Pusalkar, Yuexian Li, Karthik Venkatakrishnan, Suresh K. Balani, Lawrence Cohen, Xiaofei Zhou, Wen Chyi Shyu, Jun Johnny Yang, Swapan Chowdhury, Chuang Lu

Publikováno v: Drug Metabolism and Disposition. 48:217-229

Alisertib (MLN8237) is an investigational, orally available, selective aurora A kinase inhibitor in clinical development for the treatment of solid tumors and hematologic malignancies. This metabolic profiling analysis was conducted as part of a broa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::166eb285f2919cd372a7ec5c53356ca7
https://doi.org/10.1124/dmd.119.087338

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Development of minimal physiologically-based pharmacokinetic-pharmacodynamic models for characterizing cellular kinetics of CAR T cells following local deliveries in mice

Autor: Chia-Hung Tsai, Aman P. Singh, Cindy Q. Xia, Haiqing Wang

Publikováno v: Journal of pharmacokinetics and pharmacodynamics. 49(5)

Chimeric antigen receptor (CAR) T cell therapies have revolutionized the treatment of hematologic malignancies and have potentials for solid tumor treatment. To overcome limited CAR T cell infiltration to solid tumors, local delivery of CAR T cells i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e47261c4dd1ffad6af8ee7cc7498161
https://pubmed.ncbi.nlm.nih.gov/35869348

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