Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Cindy L. Will"'
Autor:
Pravin Kumar Ankush Jagtap, Tomáš Kubelka, Komal Soni, Cindy L. Will, Divita Garg, Claudia Sippel, Tobias G. Kapp, Harish Kumar Potukuchi, Kenji Schorpp, Kamyar Hadian, Horst Kessler, Reinhard Lührmann, Felix Hausch, Thorsten Bach, Michael Sattler
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
So far only a few compounds have been reported as splicing modulators. Here, the authors combine high-throughput screening, chemical synthesis, NMR, X-ray crystallography with functional studies and develop phenothiazines as inhibitors for the U2AF H
Externí odkaz:
https://doaj.org/article/816cddccf4d4425e993bdca998fb63bd
Autor:
Sandra Keiper, Panagiotis Papasaikas, Cindy L. Will, Juan Valcárcel, Cyrille Girard, Reinhard Lührmann
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Human spliceosome components Smu1 and RED regulate alternative splicing. Here the authors show that Smu1 and RED are also required for constitutive splicing of short introns.
Externí odkaz:
https://doaj.org/article/4553e27de950463e8f18f5857d925e60
Autor:
Carsten Boesler, Norbert Rigo, Maria M. Anokhina, Marcel J. Tauchert, Dmitry E. Agafonov, Berthold Kastner, Henning Urlaub, Ralf Ficner, Cindy L. Will, Reinhard Lührmann
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
The assembly of the splicesome involves several distinct stages that require the sequential action of DExD/H-box RNA helicases. Here, the authors uncover a new intermediate, the pre-B complex, that accumulates in the presence of an inactive form of t
Externí odkaz:
https://doaj.org/article/e7d1d18e40824533a67b9650add6c83c
Autor:
Olexandr Dybkov, Marco Preußner, Leyla El Ayoubi, Vivi-Yun Feng, Caroline Harnisch, Kilian Merz, Paula Leupold, Peter Yudichev, Dmitry E. Agafonov, Cindy L. Will, Cyrille Girard, Christian Dienemann, Henning Urlaub, Berthold Kastner, Florian Heyd, Reinhard Lührmann
Publikováno v:
Science Advances
Alternative precursor messenger RNA splicing is instrumental in expanding the proteome of higher eukaryotes, and changes in 3′ splice site (3'ss) usage contribute to human disease. We demonstrate by small interfering RNA–mediated knockdowns, foll
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::219decd2dc12850c4405043971115062
Autor:
Vinay Kumar, Zhenwei Zhang, Norbert Rigo, Jean-Baptiste Fourmann, Cindy L. Will, Reinhard Lührmann, Henning Urlaub, Olexandr Dybkov, Holger Stark
Publikováno v:
Nature
During the splicing of introns from precursor messenger RNAs (pre-mRNAs), the U2 small nuclear ribonucleoprotein (snRNP) must undergo stable integration into the spliceosomal A complex—a poorly understood, multistep process that is facilitated by t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7a4a57e53f03a2f6a2ade532cec6a90
https://doi.org/10.1038/s41586-021-03789-5
https://doi.org/10.1038/s41586-021-03789-5
Autor:
Anzhalika Sidarovich, Cindy L Will, Maria M Anokhina, Javier Ceballos, Sonja Sievers, Dmitry E Agafonov, Timur Samatov, Penghui Bao, Berthold Kastner, Henning Urlaub, Herbert Waldmann, Reinhard Lührmann
Publikováno v:
eLife, Vol 6 (2017)
Small molecule inhibitors of pre-mRNA splicing are important tools for identifying new spliceosome assembly intermediates, allowing a finer dissection of spliceosome dynamics and function. Here, we identified a small molecule that inhibits human pre-
Externí odkaz:
https://doaj.org/article/db1e5a6f34b4401e948028326c4304a0
Autor:
S. Zhang, C. T. Chen, Yuzhen Ye, Xuxu Fan, Yanrui Yang, Henning Urlaub, Sebastian E. J. Ludwig, Cindy L. Will, Zefeng Wang, Qing Lu, Reinhard Lührmann, Jin-Yan Sun
Although most eukaryotic mRNAs require a 5′-cap for translation initiation, some can also be translated through a poorly studied cap-independent pathway. Here we developed a circRNA-based system and unbiasedly identified more than 10,000 sequences
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d1e52a06d4600cb5b95847fe405d0d6c
https://doi.org/10.1101/2021.05.28.446092
https://doi.org/10.1101/2021.05.28.446092
Autor:
Jennifer C Hofmann, Justus Tegha-Dunghu, Stefanie Dräger, Cindy L Will, Reinhard Lührmann, Oliver J Gruss
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e74851 (2013)
The conserved Prp19 (pre-RNA processing 19) complex is required for pre-mRNA splicing in eukaryotic nuclei. Recent RNAi screens indicated that knockdown of Prp19 complex subunits strongly delays cell proliferation. Here we show that knockdown of the
Externí odkaz:
https://doaj.org/article/44c9a1673e0142508127bd6188cb3074
Autor:
Henning Urlaub, Leyla El Ayoubi, K. Bertram, Dmitry E. Agafonov, Olexandr Dybkov, Klaus Hartmuth, Holger Stark, Berthold Kastner, Cindy L. Will, Reinhard Lührmann
Publikováno v:
Molecular cell. 80(1)
Summary Human spliceosomes contain numerous proteins absent in yeast, whose functions remain largely unknown. Here we report a 3D cryo-EM structure of the human spliceosomal C complex at 3.4 A core resolution and 4.5–5.7 A at its periphery, and aid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3de209580214255f2032282b8915017d
https://pubmed.ncbi.nlm.nih.gov/33007253
https://pubmed.ncbi.nlm.nih.gov/33007253
Autor:
Henning Urlaub, Klaus Hartmuth, Cindy L. Will, K. Bertram, Reinhard Lührmann, Olexandr Dybkov, Holger Stark, Dmitry E. Agafonov, Berthold Kastner, Wen-Ti Liu
Publikováno v:
Nature
Spliceosome rearrangements facilitated by RNA helicase PRP16 before catalytic step two of splicing are poorly understood. Here we report a 3D cryo-electron microscopy structure of the human spliceosomal C complex stalled directly after PRP16 action (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5d9db70a5b2c982d1463509c6f9005a
https://doi.org/10.1038/nature21079
https://doi.org/10.1038/nature21079