Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Cindy L. Hochstetler"'
Autor:
Chuntao Zhao, Cuiqing Fan, Ashley Kuenzi Davis, Mohammad Azam, Meenu Kesarwani, Xiaoyi Chen, Cindy L. Hochstetler, Feng Zhang, Weidong Tian, Xiongwei Cai, Yi Zheng, Gang Huang, Fukun Guo, Q. Richard Lu, Zhaowei Tu, Lingli Xu
Publikováno v:
Proc Natl Acad Sci U S A
The mechanistic target of rapamycin (mTOR) is a central regulator of cell growth and an attractive anticancer target that integrates diverse signals to control cell proliferation. Previous studies using mTOR inhibitors have shown that mTOR targeting
Autor:
Wei Liu, Xin Duan, James C. Mulloy, H. Leighton Grimes, Cindy L. Hochstetler, Benjamin Mizukawa, Yi Zheng, Eric O'Brien, Emily Orr, Daniel C. Moreira, Mark Wunderlich
Publikováno v:
Blood. 130(11)
As a central regulator of cell polarity, the activity of CDC42 GTPase is tightly controlled in maintaining normal hematopoietic stem and progenitor cell (HSC/P) functions. We found that transformation of HSC/P to acute myeloid leukemia (AML) is assoc
Autor:
Xiaoyi Chen, Cuiqing Fan, Weidong Tian, Xiongwei Cai, Yi Zheng, Feng Zhang, Cindy L. Hochstetler, Fukun Guo
Publikováno v:
Blood. 132:2632-2632
mTOR plays a critical role in controlling cell growth, survival and metabolism and is an important anti-cancer target. There are over 2,000 clinical trials involving mTOR inhibitors as single or combo-agent. The first gen mTOR inhibitors, i.e. rapamy
Publikováno v:
Blood. 128:174-174
The bone marrow niche is an important milieu where hematopoietic stem and progenitor cells (HSPCs) are maintained to ensure their lifelong contribution to hematopoiesis. Recent evidence has highlighted the critical importance of the perivascular bone