Výsledky vyhledávání - "Cindy L. Fisher"

First-in-Human Phase 1 Study To Assess Safety, Tolerability, and Pharmacokinetics of a Novel Antifungal Drug, VL-2397, in Healthy Adults

Autor: Pamela A Resch, Andrew M Hopkins, Mammen P Mammen, Danielle Armas, Denis Rusalov, Frank H Hughes, Larry R. Smith, Sean M. Sullivan, Cindy L. Fisher

Publikováno v: Antimicrobial Agents and Chemotherapy. 63

VL-2397 is an antifungal drug with a novel mechanism of action, rapid fungicidal in vitro activity, and potent in vivo activity against Aspergillus fumigatus, including azole-resistant strains. VL2397-101, a phase 1 first-in-human, randomized, double

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f8d4a453ac750e8d05bcc7e9bec09c7
https://doi.org/10.1128/aac.00969-19

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Density Functional and Electrostatic Calculations of Manganese Superoxide Dismutase Active Site Complexes in Protein Environments

Autor: Robert Konecny, Cindy L. Fisher, Louis Noodleman, Jian Li, Donald Bashford

Publikováno v: Inorganic Chemistry. 38:929-939

Density functional and electrostatic methods have been applied to calculate active site geometries and the redox potential of manganese superoxide dismutase (MnSOD). The initial active site clusters were built up by including only first-shell side ch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa58fc16e05553aeb8370923d24692bb
https://doi.org/10.1021/ic980731o

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Computational, pulse-radiolytic, and structural investigations of lysine-136 and its role in the electrostatic triad of human C u,Z n superoxide dismutase

Autor: John A. Tainer, Terence P. Lo, Diane E. Cabelli, Paul Beroza, Robert A. Hallewell, Cindy L. Fisher, Elizabeth D. Getzoff

Publikováno v: Proteins: Structure, Function, and Genetics. 29:103-112

Key charged residues in Cu,Zn superoxide dismutase (Cu,Zn SOD) promote electrostatic steering of the superoxide substrate to the active site Cu ion, resulting in dismutation of superoxide to oxygen and hydrogen peroxide. Lys-136, along with the adjac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e328206951afca68837725f9a86d83f7
https://doi.org/10.1002/(sici)1097-0134(199709)29:1<103::aid-prot8>3.0.co

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Calculation of Redox Potentials and pKa Values of Hydrated Transition Metal Cations by a Combined Density Functional and Continuum Dielectric Theory

Autor: and Donald Bashford, Cindy L. Fisher, Jun L. Chen, Jian Li, Louis Noodleman

Publikováno v: Inorganic Chemistry. 35:4694-4702

Density functional and continuum dielectric theories have been combined to calculate molecular properties such as hydration enthalpies, redox potentials, and absolute pKa values of transition metal cations in solution. The discrete cluster model, whi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3307346ddfc2a43b2dabf558a71c5510
https://doi.org/10.1021/ic951428f

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Density-Functional and Electrostatic Calculations for a Model of a Manganese Superoxide Dismutase Active Site in Aqueous Solution

Autor: Cindy L. Fisher, Louis Noodleman, Jian Li, Jun-Liang Chen, Donald Bashford

Publikováno v: The Journal of Physical Chemistry. 100:13498-13505

We have calculated the redox potential for a solvated manganese superoxide dismutase active-site model by immersing the solute described quantum mechanically into a continuum dielectric representation of an aqueous environment. Active-site models con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4c75e7c4465db35fce9ef5c99b6280fb
https://doi.org/10.1021/jp960713x

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Models of the serine protease domain of the human antithrombotic plasma factor activated protein C and its zymogen

Autor: Cindy L. Fisher, Judith S. Greengard, John H. Griffin

Publikováno v: Protein Science. 3:588-599

Three-dimensional structural analysis of physiologically important serine proteases is useful in identifying functional features relevant to the expression of their activities and specificities. The human serine protease anticoagulant protein C is cu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d190e92aa3530250a9426a872ae1db2a
https://doi.org/10.1002/pro.5560030407

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Structural basis for type I and type II deficiencies of antithrombotic plasma protein C: Patterns revealed by three-dimensional molecular modelling of mutations of the protease domain

Autor: Cindy L. Fisher, John H. Griffin, Judith S. Greengard, Bruno O. Villoutreix

Publikováno v: Proteins: Structure, Function, and Genetics. 18:367-380

Familial deficiency of protein C is associated with inherited thrombophilia. To explore how specific missense mutations might cause observed clinical phenotypes, know protein C missense mutations were mapped onto three-dimensional homology models of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5aafef39e14ce3ba8baf4117e65819f2
https://doi.org/10.1002/prot.340180407

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Possible Structural Implications of 20 Mutations in the Protein C Protease Domain

Autor: John H. Griffin, Judith S. Greengard, Cindy L. Fisher

Publikováno v: Thrombosis and Haemostasis. 72:869-873

SummaryAnalysis of naturally occurring protein mutations yields valuable insights into functionally important sequences. Characterizing mutations responsible for protein C deficiency at the molecular level has been the subject of intensive investigat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::39dac8a7c70bef57b00c9e13fe9404d9
https://doi.org/10.1055/s-0038-1648976

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The interdependence of protein surface topography and bound water molecules revealed by surface accessibility and fractal density measures

Autor: Michael A. Siani, Elizabeth D. Getzoff, Cindy L. Fisher, Leslie A. Kuhn, Michael E. Pique, John A. Tainer

Publikováno v: Journal of Molecular Biology. 228:13-22

To characterize water binding to proteins, which is fundamental to protein folding, stability and activity, the relationships of 10,837 bound water positions to protein surface shape and residue type were analyzed in 56 high-resolution crystallograph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5072d67e0a3b4c85378317f66641029
https://doi.org/10.1016/0022-2836(92)90487-5

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