Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Cindy L. Fisher"'
Autor:
Pamela A Resch, Andrew M Hopkins, Mammen P Mammen, Danielle Armas, Denis Rusalov, Frank H Hughes, Larry R. Smith, Sean M. Sullivan, Cindy L. Fisher
Publikováno v:
Antimicrobial Agents and Chemotherapy. 63
VL-2397 is an antifungal drug with a novel mechanism of action, rapid fungicidal in vitro activity, and potent in vivo activity against Aspergillus fumigatus, including azole-resistant strains. VL2397-101, a phase 1 first-in-human, randomized, double
Autor:
Mark D. Shenderovich, Cindy L. Fisher, Vladimir Tseitin, Michael J. Dudek, S. McDonald, Muthuchidambaram Prabhakaran, Kal Ramnarayan, Shankari Mylvaganam, R. Kodandapani, Jian Hua Zheng, G. Raghunathan
Publikováno v:
Current Proteomics. 2:233-258
Publikováno v:
Inorganic Chemistry. 38:929-939
Density functional and electrostatic methods have been applied to calculate active site geometries and the redox potential of manganese superoxide dismutase (MnSOD). The initial active site clusters were built up by including only first-shell side ch
Autor:
John A. Tainer, Terence P. Lo, Diane E. Cabelli, Paul Beroza, Robert A. Hallewell, Cindy L. Fisher, Elizabeth D. Getzoff
Publikováno v:
Proteins: Structure, Function, and Genetics. 29:103-112
Key charged residues in Cu,Zn superoxide dismutase (Cu,Zn SOD) promote electrostatic steering of the superoxide substrate to the active site Cu ion, resulting in dismutation of superoxide to oxygen and hydrogen peroxide. Lys-136, along with the adjac
Publikováno v:
Inorganic Chemistry. 35:4694-4702
Density functional and continuum dielectric theories have been combined to calculate molecular properties such as hydration enthalpies, redox potentials, and absolute pKa values of transition metal cations in solution. The discrete cluster model, whi
Publikováno v:
The Journal of Physical Chemistry. 100:13498-13505
We have calculated the redox potential for a solvated manganese superoxide dismutase active-site model by immersing the solute described quantum mechanically into a continuum dielectric representation of an aqueous environment. Active-site models con
Publikováno v:
Protein Science. 3:588-599
Three-dimensional structural analysis of physiologically important serine proteases is useful in identifying functional features relevant to the expression of their activities and specificities. The human serine protease anticoagulant protein C is cu
Publikováno v:
Proteins: Structure, Function, and Genetics. 18:367-380
Familial deficiency of protein C is associated with inherited thrombophilia. To explore how specific missense mutations might cause observed clinical phenotypes, know protein C missense mutations were mapped onto three-dimensional homology models of
Publikováno v:
Thrombosis and Haemostasis. 72:869-873
SummaryAnalysis of naturally occurring protein mutations yields valuable insights into functionally important sequences. Characterizing mutations responsible for protein C deficiency at the molecular level has been the subject of intensive investigat
Autor:
Michael A. Siani, Elizabeth D. Getzoff, Cindy L. Fisher, Leslie A. Kuhn, Michael E. Pique, John A. Tainer
Publikováno v:
Journal of Molecular Biology. 228:13-22
To characterize water binding to proteins, which is fundamental to protein folding, stability and activity, the relationships of 10,837 bound water positions to protein surface shape and residue type were analyzed in 56 high-resolution crystallograph