Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Cindy Karouta"'
Autor:
Kate Thomson, Cindy Karouta, Daniel Weber, Nichola Hoffmann, Ian Morgan, Tamsin Kelly, Regan Ashby
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 167, Iss , Pp 115542- (2023)
The muscarinic cholinergic antagonist atropine is the most widely used pharmacological treatment for the visual disorder myopia (short-sightedness), the leading cause of low-vision worldwide. This study sought to better define the mechanism by which
Externí odkaz:
https://doaj.org/article/5b8fa8b8967b48848e3ad5177163412d
Autor:
Kate Thomson, Cindy Karouta, Faran Sabeti, Nicola Anstice, Myra Leung, Tina Jong, Ted Maddess, Ian G. Morgan, Jeremy Game, Regan Ashby
Publikováno v:
Clinical and Translational Science, Vol 15, Iss 11, Pp 2673-2684 (2022)
Abstract Myopia is the leading cause of low vision worldwide and can lead to significant pathological complications. Therefore, to improve patient outcomes, the field continues to develop novel interventions for this visual disorder. Accordingly, thi
Externí odkaz:
https://doaj.org/article/efe1d0bd26ae4e5595d107aace05042a
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-1 (2021)
Externí odkaz:
https://doaj.org/article/27818dc31b2d4bf994756bd3f52492ac
Publikováno v:
British Journal of Pharmacology. 178:4501-4517
BACKGROUND AND PURPOSE The ability of the muscarinic cholinergic antagonist atropine to inhibit myopia development in humans and animal models would suggest that cholinergic hyperactivity may underlie myopic growth. To test this, we investigated whet
Publikováno v:
The FASEB Journal. 36
Visually induced changes in the expression of early growth response-1 (EGR1), FBJ osteosarcoma oncogene (FOS), and NGFI-A binding protein-2 (NAB2) appear to form a part of a retinal network fundamental to ocular growth regulation, and thus, the devel
Autor:
Regan Ashby, Cindy Karouta, Ryszard Maleszka, Ian G. Morgan, Kate Thomson, Kristine Hardy, Robert Kucharski
Publikováno v:
The FASEB Journal. 35
Myopia (short-sightedness), usually caused by excessive elongation of the eye during development, has reached epidemic proportions worldwide. In animal systems including the chicken model, several treatments have been shown to inhibit ocular elongati
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-1 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-1 (2021)
Animal models have demonstrated a link between dysregulation of the retinal dopamine system and the development of myopia (short-sightedness). We have previously demonstrated that topical application of levodopa in chicks can inhibit the development
Publikováno v:
Investigative Ophthalmology & Visual Science
Purpose Topical application of levodopa inhibits the development of form-deprivation myopia (FDM) and lens-induced myopia (LIM) in chicks. Here we examine whether coadministration with carbidopa enhances this protection and compare the effectiveness
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-17 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-17 (2019)
Animal models have demonstrated a link between dysregulation of the retinal dopamine system and the excessive ocular growth associated with the development of myopia. Here we show that intravitreal or topical application of levodopa, which is widely
Publikováno v:
Experimental Eye Research. 200:108233
Purpose Animal models have demonstrated a link between dysregulation of the retinal dopamine system and the development of experimental myopia (short-sightedness). However, pharmacological investigations of dopamine in animal models rely heavily on i