Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Cindy K Bahler"'
Autor:
Tommy A Rinkoski, Cindy K Bahler, Johann M Pacheco, Maya L Khanna, David M Holmes, Uttio Roy Chowdhury, Keith H Baratz, Sanjay V Patel, Leo J Maguire, Eric D Wieben, Michael P Fautsch
Publikováno v:
PLoS ONE, Vol 16, Iss 9, p e0258006 (2021)
Primary cultures of human corneal endothelial cells (HCECs) are an important model system for studying the pathophysiology of corneal endothelium. The purpose of this study was to identify and validate an optimal primary culture model of normal and F
Externí odkaz:
https://doaj.org/article/80d4ea72a60048aca716b4c0b6854e4d
Autor:
Uttio Roy Chowdhury, Rachel A Kudgus, Tommy A Rinkoski, Bradley H Holman, Cindy K Bahler, Cheryl R Hann, Joel M Reid, Peter I Dosa, Michael P Fautsch
Publikováno v:
PLoS ONE, Vol 15, Iss 4, p e0231841 (2020)
Elevated intraocular pressure is the only treatable risk factor for glaucoma, an eye disease that is the leading cause of irreversible blindness worldwide. We have identified cromakalim prodrug 1 (CKLP1), a novel water-soluble ATP-sensitive potassium
Externí odkaz:
https://doaj.org/article/fa3ee5a25e0c4533837d93f3c27cfe39
Publikováno v:
PLoS ONE, Vol 12, Iss 6, p e0179345 (2017)
Elevated intraocular pressure is the most prevalent and only treatable risk factor for glaucoma, a degenerative disease of the optic nerve. While treatment options to slow disease progression are available, all current therapeutic and surgical treatm
Externí odkaz:
https://doaj.org/article/113c71648ee849eda29e38f0fb88928b
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0144791 (2015)
Externí odkaz:
https://doaj.org/article/6c3b5240e816482bb33c736744ced5d9
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0141783 (2015)
Elevated intraocular pressure (IOP) is the most prevalent and only treatable risk factor for glaucoma, a leading cause of irreversible blindness worldwide. Unfortunately, all current therapeutics used to treat elevated IOP and glaucoma have significa
Externí odkaz:
https://doaj.org/article/159a581a5e974052abbca76c8247036d
Autor:
Michael P. Fautsch, Eric McCloud, Uttio Roy Chowdhury, Cheryl R. Hann, Bradley H. Holman, Cindy K. Bahler, Tommy A. Rinkoski, Peter I. Dosa, Joel M. Reid, Rachel A. Kudgus, Susan E. Appt
Publikováno v:
J Ocul Pharmacol Ther
Purpose: To evaluate pharmacokinetic parameters and ocular hypotensive effects of cromakalim prodrug 1 (CKLP1) in normotensive large animal models. Methods: Optimal CKLP1 concentration was determined by dose response and utilized in short- (5–8 day
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af3c997d03d0a608afeb32fe104b8458
https://pubmed.ncbi.nlm.nih.gov/33784195
https://pubmed.ncbi.nlm.nih.gov/33784195
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports
Scientific Reports
Ocular hypertension occurs due to increased resistance to aqueous humor removal through the conventional outflow pathway. Unlike the proximal region of the conventional outflow pathway, the distal region has not been well studied, mostly due to lack
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eba5fa522cecf52c909db68074239024
https://doi.org/10.1038/s41598-021-83558-6
https://doi.org/10.1038/s41598-021-83558-6
Autor:
Sanjay V. Patel, Keith H. Baratz, Johann M. Pacheco, Cindy K. Bahler, Leo J. Maguire, David M. Holmes, Eric D. Wieben, Uttio Roy Chowdhury, Tommy A. Rinkoski, Michael P. Fautsch, Maya L. Khanna
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 9, p e0258006 (2021)
PLoS ONE, Vol 16, Iss 9, p e0258006 (2021)
Primary cultures of human corneal endothelial cells (HCECs) are an important model system for studying the pathophysiology of corneal endothelium. The purpose of this study was to identify and validate an optimal primary culture model of normal and F
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3750d90b13ee0b6196942b6bf788ede
https://doi.org/10.1371/journal.pone.0258006
https://doi.org/10.1371/journal.pone.0258006
Autor:
Tommy A. Rinkoski, Cheryl R. Hann, Uttio Roy Chowdhury, Michael P. Fautsch, Peter I. Dosa, Bradley H. Holman, Joel M. Reid, Rachel A. Kudgus, Cindy K. Bahler
Publikováno v:
PLoS ONE, Vol 15, Iss 4, p e0231841 (2020)
PLoS ONE
PLoS ONE
Elevated intraocular pressure is the only treatable risk factor for glaucoma, an eye disease that is the leading cause of irreversible blindness worldwide. We have identified cromakalim prodrug 1 (CKLP1), a novel water-soluble ATP-sensitive potassium
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a7b32aab089ea75a322fad5b3d1b586
https://doi.org/10.1371/journal.pone.0231841
https://doi.org/10.1371/journal.pone.0231841
Autor:
Cindy K. Bahler, Bradley H. Holman, Uttio Roy Chowdhury, Peter I. Dosa, Kristen L. Stoltz, Michael P. Fautsch, Jacques Bertrand, Joseph M. Sherwood, Tommy A. Rinkoski, J. Cameron Millar, Darryl R. Overby
Publikováno v:
Investigative Ophthalmology & Visual Science
Purpose: Cromakalim prodrug 1 (CKLP1) is a water-soluble ATP-sensitive potassium channel opener that has shown ocular hypotensive properties in ex vivo and in vivo experimental models. To determine its mechanism of action, we assessed the effect of C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d9eceb4d1b37a437c04a21b5d41b538
http://hdl.handle.net/10044/1/54682
http://hdl.handle.net/10044/1/54682
