Výsledky vyhledávání - "Cindy J. Pauley"

Characterization of integration frequency and insertion sites of adenovirus DNA into mouse liver genomic DNA following intravenous injection

Autor: Zhibin, Wang, Philip J, Troilo, Thomas G, Griffiths, Laural B, Harper, Amy B, Barnum, Stephen J, Pacchione, Cindy J, Pauley, Jose A, Lebron, Jayanthi, Wolf, Brian J, Ledwith

Publikováno v: Gene therapy. 29(6)

While generally referred to as "non-integrating" vectors, adenovirus vectors have the potential to integrate into host DNA via random, illegitimate (nonhomologous) recombination. The present study provides a quantitative assessment of the potential i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e5ccc71c22ad494506ad0ada50fa9db1
https://pubmed.ncbi.nlm.nih.gov/34404916

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Lack of effects on male fertility from a quadrivalent HPV vaccine in Sprague-Dawley rats

Autor: Jayanthi J. Wolf, L. David Wise, Cindy J. Pauley, Bindhu Michael

Publikováno v: Birth Defects Research Part B: Developmental and Reproductive Toxicology. 89:376-381

BACKGROUND: Human papillomavirus (HPV) infection is one of the most common sexually transmitted diseases in both men and women. A recently developed quadrivalent HPV vaccine, Gardasil®, has been shown to be highly effective in the prevention of seve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86ce87c2b6c5536babf40cfa2d0fee02
https://doi.org/10.1002/bdrb.20259

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Plasmid DNA Vaccines: Investigation of Integration into Host Cellular DNA following Intramuscular Injection in Mice

Autor: Cindy J. Pauley, Warren W. Nichols, Carolann M. Beare, Amy B. Barnum, Sujata Manam, Walter J. Bagdon, Philip J. Troilo, Brian J. Ledwith, Laural B. Harper, Thomas G. Griffiths

Publikováno v: Intervirology. 43:258-272

The primary safety concern for DNA vaccines is their potential to integrate into the host cell genome. We describe an integration assay based on purification of high-molecular-weight genomic DNA away from free plasmid using gel electrophoresis, such

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e69a9a146e0bf5dbd4a9662a6afe7cfe
https://doi.org/10.1159/000053993

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Plasmid DNA Vaccines: Tissue Distribution and Effects of DNA Sequence, Adjuvants and Delivery Method on Integration into Host DNA

Autor: Zhibin Wang, Warren W. Nichols, Laural B. Harper, Walter J. Bagdon, Thomas G. Griffiths, B J Ledwith, Lyudmila Denisova, Philip J. Troilo, Zhutian Niu, Thy T. Follmer, Amy B. Barnum, Sujata Manam, Carolann M. Beare, Stephen Pacchione, Cindy J. Pauley

Publikováno v: Intervirology. 43:273-281

A variety of factors could affect the frequency of integration of plasmid DNA vaccines into host cellular DNA, including DNA sequences within the plasmid, the expressed gene product (antigen), the formulation, delivery method, route of administration

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52d4d55e7fcb83c9a68c4ac8db5a1c6a
https://doi.org/10.1159/000053994

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Lack of effects on fertility and developmental toxicity of a quadrivalent HPV vaccine in Sprague-Dawley rats

Autor: L. David Wise, Cindy J. Pauley, Jayanthi J. Wolf, Catherine Kaplanski, Brian J. Ledwith

Publikováno v: Birth defects research. Part B, Developmental and reproductive toxicology. 83(6)

Human papillomavirus (HPV) infection is one of the most common sexually transmitted diseases, with approximately half of the HPV-infected people being adolescents and young adults. A recently developed quadrivalent HPV vaccine, GARDASIL((R)), has bee

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe2efbb786c68ebb609b005dde4bacd3
https://pubmed.ncbi.nlm.nih.gov/19025783

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Detection of integration of plasmid DNA into host genomic DNA following intramuscular injection and electroporation

Autor: T T Follmer, Cindy J. Pauley, S J Pacchione, Brian J. Ledwith, Gabriella Rizzuto, Elena Fattori, Zhibin Wang, Nicola La Monica, Gennaro Ciliberto, X Wang, Thomas G. Griffiths, A B Barnum, Sujata Manam, L Denisova, L B Harper, Z Niu, Philip Troilo

Publikováno v: Gene therapy. 11(8)

Plasmid vectors have been widely used for DNA vaccines and gene therapy. Following intramuscular injection, the plasmid that persists is extrachromosomal and integration into host DNA, if it occurs at all, is negligible. However, new technologies for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d89594fff9b56a5a2d497f5739f509ea
https://pubmed.ncbi.nlm.nih.gov/14724672

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Peroxisome proliferators activate growth regulatory pathways largely via peroxisome proliferator-activated receptor alpha-independent mechanisms

Autor: Catherine Kaplanski, Brian J. Ledwith, Cindy J. Pauley

Publikováno v: Cellular signalling. 14(4)

Peroxisome proliferators (PPs) induce liver tumors in rodents through an unknown mechanism requiring PP-activated receptor (PPAR) alpha. Since PPs possess growth modulatory activities that may be important to their hepatocarcinogenicity, we aimed at

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d85d66eab7a002de88c439cff71208b8
https://pubmed.ncbi.nlm.nih.gov/11858942

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Induction of cyclooxygenase-2 expression by peroxisome proliferators and non-tetradecanoylphorbol 12,13-myristate-type tumor promoters in immortalized mouse liver cells

Autor: David W. Alberts, Cindy J. Pauley, Carrie L. Rokos, Sujata Manam, Linda K. Wagner, Brian J. Ledwith

Publikováno v: The Journal of biological chemistry. 272(6)

Increased expression of cyclooxygenase-2 (COX-2), the rate-limiting enzyme in prostaglandin synthesis, has been associated with growth regulation and carcinogenesis in several systems. COX-2 is known to be induced by cytokines and the skin tumor prom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75bbe892960606aab0b2e7fbbc5571be
https://pubmed.ncbi.nlm.nih.gov/9013627

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Subject Index Vol. 43, 2000

Autor: Amy B. Barnum, Sergey N. Kochetkov, N. Tordo, Gösta Winberg, H.P. Hefti, Natalia N. Petrakova, Minchao Chen, Zhibin Wang, Sujata Manam, Maria G. Isaguliants, J. Schultz, Jeffrey B. Ulmer, Dan H. Barouch, B. Hejdeman, Jeong-Im Sin, Stephen J. Pacchione, Fengfeng Xu, Mei Hong, P. Perrin, Karin Mölling, R. Z. Gizatullin, Thomas G. Griffiths, Carolann M. Beare, Katja Pokrovskaya, Mark J. Selby, Anne Kjerrström, Cindy J. Pauley, E. Operschall, Laural B. Harper, Zhutian Niu, Bartek Zuber, Warren W. Nichols, D. A. Kostyuk, Mary Schaefer, Gillis R. Otten, B. Wahren, Tong Wu, Cheryl Goldbeck, T. Schuh, David B. Weiner, Britta Wahren, Y. Jacob, Thy T. Follmer, Klaus Cichutek, K. Mölling, Walter J. Bagdon, A.L. Hultström, Brian J. Ledwith, Michael J. McCluskie, Jorma Hinkula, Lyudmila Denisova, G. Bratt, Günter Dollenmaier, Barbara Doe, Lacrimiora Comanita, Philip J. Troilo, Jan Schultz, J. Pavlovic, Norman L. Letvin, Risini D. Weeratna, Kenneth Lundstrom, M. Nawrath, E. Carbone, Heather L. Davis, A.C. Leandersson

Publikováno v: Intervirology. 43:343-344

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::faf95d40fcf01e52298ae711f27ec3e2
https://doi.org/10.1159/000054005

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