Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Cindy E. Nuss"'
Autor:
Rowena V. Cube, Cindy E. Nuss, Thomayant Prueksaritanont, Scott M. Doran, Jim Small, Wei Zeng, Julie Ann Luk, Cynthia Chavez-Eng, William O. Cook, T Laethem, Victor N. Uebele, Susan L. Garson, Thomas S. Reger, Richard L. Kraus, Yuhsin Kuo, Christa Mattern, Wei Fang, Cuyue Tang, John J. Renger, Paul J. Coleman, Kelly Ann S. Schlegel, Adekemi B. Taylor, Yuxing Li, Zhi Qiang Yang, James C. Barrow, Shu Youheng, Jeanine E. Ballard, Matthew D. Troyer, George D. Hartman, Steven V. Fox
Publikováno v:
ACS Medicinal Chemistry Letters. 1:504-509
A novel phenyl acetamide series of short-acting T-type calcium channel antagonists has been identified and evaluated using in vitro and in vivo assays. Heterocycle substitutions of the 4-position of the phenyl acetamides afforded potent and selective
Autor:
Scott M. Doran, Kenneth E. Rittle, Yuxing Li, Cindy E. Nuss, Faith A. Mullen, Jeanine E. Ballard, Razvan Cristescu, Thomas S. Reger, Zhi-Qiang Yang, John J. Renger, Kenneth S. Koblan, Owen B. McManus, Vincent P. Santarelli, Rodney A. Bednar, Victor N. Uebele, Cuyue Tang, Susan L. Garson, Kelly-Ann S. Schlegel, Richard L. Kraus, Æ James C. Barrow, Ge Dai, Wei Lemaire, Steven V. Fox
Publikováno v:
Cell Biochemistry and Biophysics. 55:81-93
Low-voltage-activated (T-type) calcium channels play a role in diverse physiological responses including neuronal burst firing, hormone secretion, and cell growth. To better understand the biological role and therapeutic potential of the target, a nu
Autor:
Vincent P. Santarelli, Victor N. Uebele, Sara J. Aton, Julie Seibt, Tammi Coleman, Marcos G. Frank, John J. Renger, Shaun R Stauffer, Susan L. Garson, Sushil K. Jha, Kenneth S. Koblan, Michelle C. Dumoulin, James C. Barrow, Cindy E. Nuss
Publikováno v:
NeuroReport. 20:257-262
T-type voltage-dependent calcium channels may play an important role in synaptic plasticity, but lack of specific antagonists has hampered investigation into this possible function. We investigated the role of the T-type channel in a canonical model
Autor:
Cindy E. Nuss, John J. Renger, Isabelle Bidaud, Philippe Lory, Jean Chemin, Magali Cazade, Victor N. Uebele
Publikováno v:
Molecular Pharmacology
Molecular Pharmacology, American Society for Pharmacology and Experimental Therapeutics, 2014, 85 (2), pp.218--225. ⟨10.1124/mol.113.089581⟩
Molecular Pharmacology, American Society for Pharmacology and Experimental Therapeutics, 2014, 85 (2), pp.218--225. ⟨10.1124/mol.113.089581⟩
T-type calcium channels (T/Ca(v)3-channels) are implicated in various physiologic and pathophysiologic processes such as epilepsy, sleep disorders, hypertension, and cancer. T-channels are the target of endogenous signaling lipids including the endoc
Autor:
David W. Alberts, Alastair E. Cribb, Scott J. Grossman, Cindy E. Nuss, S P Spielberg, Diane B. Lamphere, Denis M. Grant
Publikováno v:
Chemical Research in Toxicology. 9:500-507
Potentially serious idiosyncratic reactions associated with sulfamethoxazole (SMX) include systemic hypersensitivity reactions and hepatotoxicity. Covalent binding of SMX to proteins subsequent to its N-hydroxylation to form N4-hydroxysulfamethoxazol
Publikováno v:
Biomarkers. 1:267-272
Sulphonamide hypersensitivity reactions are believed to be mediated through reactive intermediates derived from oxidation of the paraamino group to form sulphonamide hydroxylamines. Sulphamethoxazole hydroxylamine (SMX-HA) can be acetylated by N-acet
Autor:
Cindy E. Nuss, Thomayant Prueksaritanont, Jeanine E. Ballard, John J. Renger, Yuhsin Kuo, Steven V. Fox, Rowena V. Cube, Thomas S. Reger, Shu Youheng, James C. Barrow, Kelly Ann S. Schlegel, George D. Hartman, Cuyue Tang, Georgia B. McGaughey, Yuxing Li, Zhi Qiang Yang, Victor N. Uebele, Christa Mattern, Scott M. Doran, Susan L. Garson, Richard L. Kraus, Kenneth E. Rittle
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(6)
A novel series of amide T-type calcium channel antagonists were prepared and evaluated using in vitro and in vivo assays. Optimization of the screening hit 3 led to identification of the potent and selective T-type antagonist 37 that displayed in viv
Autor:
Cindy E. Nuss, John J. Renger, Thomas S. Reger, Jeanine E. Ballard, Thomayant Prueksaritanont, Susan L. Garson, Mark G. Bock, Youheng Shu, Yuxing Li, Zhi Qiang Yang, Richard L. Kraus, Scott M. Doran, Kenneth E. Rittle, Victor N. Uebele, Rowena V. Cube, Cuyue Tang, Phung Bondiskey, Schlegel Kelly-Ann, Yuhsin Kuo, Steven V. Fox, James C. Barrow, George D. Hartman
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(17)
The discovery and synthesis of 4,4-disubstituted quinazolinones as T-type calcium channel antagonists is reported. Based on lead compounds 2 and 3, a focused SAR campaign driven by the optimization of potency, metabolic stability, and pharmacokinetic
Autor:
Cindy E. Nuss, Valerie Kuzmick Graufelds, Phung Bondiskey, Scott M. Doran, Kenneth E. Rittle, John J. Renger, Thomas S. Reger, Thomayant Prueksaritanont, Cuyue Tang, Victor N. Uebele, Yuhsin Kuo, Michael J. Marino, Jeanine E. Ballard, Steven V. Fox, Georgia B. McGaughey, Mark G. Bock, James C. Barrow, George D. Hartman, Susan L. Garson, Richard L. Kraus, Yuxing Li, Zhi Qiang Yang
A novel series of quinazolinone T-type calcium channel antagonists have been prepared and evaluated using in vitro and in vivo assays. Optimization of the screening hit 3 by modifications of the 3- and 4-positions of the quinazolinone ring afforded p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::274e2471133e497ff4344412b6716069
https://europepmc.org/articles/PMC4007971/
https://europepmc.org/articles/PMC4007971/
Autor:
Victor N, Uebele, Cindy E, Nuss, Vincent P, Santarelli, Susan L, Garson, Richard L, Kraus, James C, Barrow, Shaun R, Stauffer, Kenneth S, Koblan, John J, Renger, Sara, Aton, Julie, Seibt, Michelle, Dumoulin, Sushil K, Jha, Tammi, Coleman, Marcos G, Frank
Publikováno v:
Neuroreport. 20(3)
T-type voltage-dependent calcium channels may play an important role in synaptic plasticity, but lack of specific antagonists has hampered investigation into this possible function. We investigated the role of the T-type channel in a canonical model