Abstract A06: Biophysical and biochemical characterization of KRAS G12C inhibition through the SMARTTM platform

Autor: Earl W. May, Meizhong Jin, Gizem Akcay, Anna Kohlmann, Sharon A. Townson, Linlong Xue, Alexander Yuzhakov, Cindy C. Benod, Ganesh Iyer, Alec D Silver, Alan S. Mann, Nicholas Perl, Minyun Zhou

Publikováno v: Molecular Cancer Research. 18:A06-A06

RAS proteins are small GTPases involved in cell proliferation, survival, and differentiation, and are mutationally activated in about a third of all human cancers. These mutations drive cancer by impairing GTPase activity so that the RAS protein is f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a684bd2145303e77787eba23f3670755
https://doi.org/10.1158/1557-3125.ras18-a06

A screening cascade to identify ERβ ligands.

Autor: Filgueira CS; Genomic Medicine, Houston Methodist Research Institute (CSF, CB, XL, PSG, RAV, ALB, PW) and Center for Nuclear Receptors and Cell Signaling, University of Houston (AS, JAG, ALB, PW), Houston, Texas, USA ., Benod C; Genomic Medicine, Houston Methodist Research Institute (CSF, CB, XL, PSG, RAV, ALB, PW) and Center for Nuclear Receptors and Cell Signaling, University of Houston (AS, JAG, ALB, PW), Houston, Texas, USA ., Lou X; Genomic Medicine, Houston Methodist Research Institute (CSF, CB, XL, PSG, RAV, ALB, PW) and Center for Nuclear Receptors and Cell Signaling, University of Houston (AS, JAG, ALB, PW), Houston, Texas, USA ., Gunamalai PS; Genomic Medicine, Houston Methodist Research Institute (CSF, CB, XL, PSG, RAV, ALB, PW) and Center for Nuclear Receptors and Cell Signaling, University of Houston (AS, JAG, ALB, PW), Houston, Texas, USA ., Villagomez RA; Genomic Medicine, Houston Methodist Research Institute (CSF, CB, XL, PSG, RAV, ALB, PW) and Center for Nuclear Receptors and Cell Signaling, University of Houston (AS, JAG, ALB, PW), Houston, Texas, USA ., Strom A; Genomic Medicine, Houston Methodist Research Institute (CSF, CB, XL, PSG, RAV, ALB, PW) and Center for Nuclear Receptors and Cell Signaling, University of Houston (AS, JAG, ALB, PW), Houston, Texas, USA ., Gustafsson JÅ; Genomic Medicine, Houston Methodist Research Institute (CSF, CB, XL, PSG, RAV, ALB, PW) and Center for Nuclear Receptors and Cell Signaling, University of Houston (AS, JAG, ALB, PW), Houston, Texas, USA ., Berkenstam AL; Genomic Medicine, Houston Methodist Research Institute (CSF, CB, XL, PSG, RAV, ALB, PW) and Center for Nuclear Receptors and Cell Signaling, University of Houston (AS, JAG, ALB, PW), Houston, Texas, USA ., Webb P; Genomic Medicine, Houston Methodist Research Institute (CSF, CB, XL, PSG, RAV, ALB, PW) and Center for Nuclear Receptors and Cell Signaling, University of Houston (AS, JAG, ALB, PW), Houston, Texas, USA .

Publikováno v: Nuclear receptor signaling [Nucl Recept Signal] 2014 Nov 04; Vol. 12, pp. e003. Date of Electronic Publication: 2014 Nov 04 (Print Publication: 2014).

Structure of the retinoid X receptor α-liver X receptor β (RXRα-LXRβ) heterodimer on DNA.

Autor: Lou X; 1] Center for Nuclear Receptors and Cell Signaling, University of Houston, Houston, Texas, USA. [2] Genomic Medicine Program, Houston Methodist Research Institute, Houston, Texas, USA., Toresson G; Department of Biosciences, Karolinska Institutet, Novum, Huddinge, Sweden., Benod C; 1] Center for Nuclear Receptors and Cell Signaling, University of Houston, Houston, Texas, USA. [2] Genomic Medicine Program, Houston Methodist Research Institute, Houston, Texas, USA., Suh JH; Genomic Medicine Program, Houston Methodist Research Institute, Houston, Texas, USA., Philips KJ; Genomic Medicine Program, Houston Methodist Research Institute, Houston, Texas, USA., Webb P; 1] Center for Nuclear Receptors and Cell Signaling, University of Houston, Houston, Texas, USA. [2] Genomic Medicine Program, Houston Methodist Research Institute, Houston, Texas, USA., Gustafsson JA; 1] Center for Nuclear Receptors and Cell Signaling, University of Houston, Houston, Texas, USA. [2] Genomic Medicine Program, Houston Methodist Research Institute, Houston, Texas, USA. [3] Department of Biosciences, Karolinska Institutet, Novum, Huddinge, Sweden.

Publikováno v: Nature structural & molecular biology [Nat Struct Mol Biol] 2014 Mar; Vol. 21 (3), pp. 277-81. Date of Electronic Publication: 2014 Feb 23.

Nuclear receptor liver receptor homologue 1 (LRH-1) regulates pancreatic cancer cell growth and proliferation.

Autor: Benod C; Department of Biochemistry and Biophysics, University of California 600 16th Street, GH S412E, San Francisco, CA 94158-2517, USA., Vinogradova MV, Jouravel N, Kim GE, Fletterick RJ, Sablin EP

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2011 Oct 11; Vol. 108 (41), pp. 16927-31. Date of Electronic Publication: 2011 Sep 26.

Discovery of a highly active ligand of human pregnane x receptor: a case study from pharmacophore modeling and virtual screening to "in vivo" biological activity.

Autor: Lemaire G; Institut National de la Santé et de la Recherche Médicale (INSERM) U824, Montpellier, Université Montpellier, Montpellier, France., Benod C, Nahoum V, Pillon A, Boussioux AM, Guichou JF, Subra G, Pascussi JM, Bourguet W, Chavanieu A, Balaguer P

Publikováno v: Molecular pharmacology [Mol Pharmacol] 2007 Sep; Vol. 72 (3), pp. 572-81. Date of Electronic Publication: 2007 Jun 15.