The human orphan nuclear receptor tailless (TLX, NR2E1) is druggable.

Autor: Cindy Benod, Rosa Villagomez, Carly S Filgueira, Peter K Hwang, Paul G Leonard, Guillaume Poncet-Montange, Senapathy Rajagopalan, Robert J Fletterick, Jan-Åke Gustafsson, Paul Webb

Publikováno v: PLoS ONE, Vol 9, Iss 6, p e99440 (2014)

Nuclear receptors (NRs) are an important group of ligand-dependent transcriptional factors. Presently, no natural or synthetic ligand has been identified for a large group of orphan NRs. Small molecules to target these orphan NRs will provide unique

Externí odkaz: https://doaj.org/article/137a4a00219b404e842bee770fbb9ed8

3,5-diiodothyronine (3,5-T2) reduces blood glucose independently of insulin sensitization in obese mice

Autor: Rosa Villagomez, Maria Tereza Nunes, Aijun Zhang, Douglas H. Sieglaff, Paul Webb, L. J. Minze, Carly S. Filgueira, Cindy Benod, S. da Silva Teixeira

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Aim Thyroid hormones regulate metabolic response. While triiodothyronine (T3) is usually considered to be the active form of thyroid hormone, one form of diiodothyronine (3,5-T2) exerts T3-like effects on energy consumption and lipid metabolism. 3,5-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30d01abe05637c80a5b7ad6efa6be593
https://pubmed.ncbi.nlm.nih.gov/28029731

CRAACK: Consensus Program for NMR Amino Acid Type Assignment

Autor: Jean-Luc Pons, Marc-André Delsuc, Cindy Benod

Publikováno v: Journal of Chemical Information and Modeling. 46:1517-1522

Protein peak spectrum assignment is a prerequisite of the nuclear magnetic resonance study of a molecule. We present here a computer tool which proposes the determination of the amino acid type from the values of the chemical shifts. This tool is bas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::449a1bc94e5c706f5ca48e3123bc264a
https://doi.org/10.1021/ci050092h

A screening cascade to identify ERβ ligands

Autor: Xiaohua Lou, Rosa A. Villagomez, Paul Webb, Jan-Åke Gustafsson, Cindy Benod, Carly S. Filgueira, Anders Ström, Prem S. Gunamalai, Anders L. Berkenstam

Publikováno v: Nuclear Receptor Signaling

The establishment of effective high throughput screening cascades to identify nuclear receptor (NR) ligands that will trigger defined, therapeutically useful sets of NR activities is of considerable importance. Repositioning of existing approved drug

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd532e87aebadd302a1c36d7d0c7c527
https://pubmed.ncbi.nlm.nih.gov/25422593

Discovery of a highly active ligand of human pregnane x receptor: a case study from pharmacophore modeling and virtual screening to 'in vivo' biological activity

Autor: William Bourguet, Géraldine Lemaire, Jean-Marc Pascussi, Patrick Balaguer, Arnaud Pillon, Anne-Marie Boussioux, Alain Chavanieu, Guy Subra, Cindy Benod, Virginie Nahoum, Jean-François Guichou

Publikováno v: Molecular Pharmacology
Molecular Pharmacology, American Society for Pharmacology and Experimental Therapeutics, 2007, 72 (3), pp.572-81. ⟨10.1124/mol.106.033415⟩
Molecular Pharmacology, 2007, 72 (3), pp.572-81. ⟨10.1124/mol.106.033415⟩

International audience; The human pregnane X receptor (hPXR) is a nuclear receptor that regulates the expression of phase I and II drug-metabolizing enzymes as well as that of drug transporters. In addition, this receptor plays a critical role in cho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6cf8e859c9e6cbc20a1df37bb4d4d39
https://www.hal.inserm.fr/inserm-00157261