Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Cindy Acon Chen"'
Publikováno v:
Toxics, Vol 8, Iss 4, p 106 (2020)
Organophosphorus compound exposure remains a present threat through agricultural accidents, warfare, or terrorist activity. The primary mechanism of organophosphorus toxicity is through inhibition of the enzyme acetylcholinesterase, with current emer
Externí odkaz:
https://doaj.org/article/6cf663c10ed04be9be55cf2c65431ee4
Autor:
Katie Walker, Linnzi K.M. Wright, Tsung-Ming Shih, Fu Du, Michael F. Stone, Zora-Maya Keith, Caroline R. Schultz, Lucille A. Lumley, Brenda Marrero-Rosado, Kimberly A. Whitten, Cindy Acon-Chen
Publikováno v:
Toxicology Reports, Vol 8, Iss, Pp 896-907 (2021)
Toxicology Reports
Toxicology Reports
Graphical abstract
Highlights • The median lethal dose of soman (GD) was estimated in adult male Göttingen minipigs. • GD exposure induces cholinesterase inhibition and behavioral seizure in minipigs. • GD induces neurodegeneration in vis
Highlights • The median lethal dose of soman (GD) was estimated in adult male Göttingen minipigs. • GD exposure induces cholinesterase inhibition and behavioral seizure in minipigs. • GD induces neurodegeneration in vis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::757661aa0cf9bbfbadc91ef4471049fd
http://www.sciencedirect.com/science/article/pii/S2214750021000810
http://www.sciencedirect.com/science/article/pii/S2214750021000810
Publikováno v:
Toxicology Mechanisms and Methods. 29:322-333
The efficacy of anticonvulsant therapies to stop seizure activities following organophosphorus nerve agents (NAs) has been documented as being time-dependent. We utilized the guinea pig NA-seizure model to compare the effectiveness of phencynonate (P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04c8f02e0a604f9b93fd1217b8a42963
https://doi.org/10.1080/15376516.2018.1558322
https://doi.org/10.1080/15376516.2018.1558322
Publikováno v:
Exp Cell Res
Concomitant treatment with deferoxamine (DFO) protects neural cells from iron and heme-mediated oxidative injury, but also disrupts cell responses to iron loading that may be protective. We hypothesized that DFO treatment and withdrawal would subsequ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbc0ac9fdcbe5ec6b92e6fe02ca9f700
https://europepmc.org/articles/PMC7301423/
https://europepmc.org/articles/PMC7301423/
Autor:
Garrett Smith, Tsung-Ming Shih, Cindy Acon-Chen, Jeffrey A. Koenig, Thaddeus P. Thomas, Amber R. Truitt
Publikováno v:
Toxicology Mechanisms and Methods. 26:378-388
Organophosphorus nerve agents such as soman (GD) inhibit acetylcholinesterase, producing an excess of acetylcholine (ACh), which results in respiratory distress, convulsions and status epilepticus that leads to neuropathology. Several drugs (topirama
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6d2b6587c459d79fc3c944d91fdf9b4
https://doi.org/10.1080/15376516.2016.1197992
https://doi.org/10.1080/15376516.2016.1197992
Publikováno v:
Toxicology mechanisms and methods. 20(9)
Organophosphorus nerve agents like cyclosarin and tabun are potent cholinesterase inhibitors. The inhibition of acetylcholinesterase, which is responsible for breaking down acetylcholine (ACh) at the synapse and neuromuscular junction, leads to a bui
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e48b934808490e1faca2a8ff236d5e16
https://pubmed.ncbi.nlm.nih.gov/20919801
https://pubmed.ncbi.nlm.nih.gov/20919801
Autor:
Lucille Lumley, Fu Du, Brenda Marrero-Rosado, Michael Stone, Zora-Maya Keith, Caroline Schultz, Kimberly Whitten, Katie Walker, Cindy Acon-Chen, Linnzi Wright, Tsung-Ming Shih
Publikováno v:
Toxicology Reports, Vol 8, Iss , Pp 896-907 (2021)
Animal models are essential for evaluating the toxicity of chemical warfare nerve agents (CWNAs) to extrapolate to human risk and are necessary to evaluate the efficacy of medical countermeasures. The Göttingen minipig is increasingly used for toxic
Externí odkaz:
https://doaj.org/article/15f8b06964f947a390606a8fa34d62cd