Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Cindy A. Evandy"'
Autor:
Sinéad Kinsella, Cindy A. Evandy, Kirsten Cooper, Lorenzo Iovino, Paul C. deRoos, Kayla S. Hopwo, David W. Granadier, Colton W. Smith, Shahin Rafii, Jarrod A. Dudakov
Publikováno v:
Cell Reports, Vol 37, Iss 1, Pp 109789- (2021)
Summary: The thymus, which is the primary site of T cell development, is particularly sensitive to insult but also has a remarkable capacity for repair. However, the mechanisms orchestrating regeneration are poorly understood, and delayed repair is c
Externí odkaz:
https://doaj.org/article/65afcaf448bd428a8b80a25ba8962d2a
Autor:
Sinéad Kinsella, Cindy A. Evandy, Kirsten Cooper, Antonella Cardinale, Lorenzo Iovino, Paul deRoos, Kayla S. Hopwo, Colton W. Smith, David Granadier, Lucas B. Sullivan, Enrico Velardi, Jarrod A. Dudakov
Endogenous thymic regeneration is a crucial process that allows for the renewal of immune competence following stress, infection or cytoreductive conditioning. Fully understanding the molecular mechanisms driving regeneration will uncover therapeutic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::18efc9a131627f508f25e89f68542965
https://doi.org/10.1101/2023.01.19.524800
https://doi.org/10.1101/2023.01.19.524800
Autor:
Alexander C. Gagnon, Mario Petrini, Paul DeRoos, Kayla S. Hopwo, Tamas Ugrai, David W. Granadier, Lorenzo Iovino, Sinéad Kinsella, Kirsten Cooper, Geoffrey R. Hill, Colton W. Smith, Kathleen S. Ensbey, Jarrod A Dudakov, Sara Galimberti, Francesco Mazziotta, Cindy A. Evandy
Prolonged lymphopenia represents a major clinical problem after cytoreductive therapies such as chemotherapy and the conditioning required for hematopoietic stem cell transplant (HCT), contributing toward the risk of infections and malignant relapse.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d9b762ec3e9db8f33239d91324977c1c
https://doi.org/10.1101/2021.09.02.458741
https://doi.org/10.1101/2021.09.02.458741
Autor:
Sinéad Kinsella, Cindy Anggelica Evandy, Kirsten Cooper, Kayla Hopwo, Lorenzo Iovino, Paul deRoos, Colton Smith, David Granadier, Jarrod A Dudakov
Publikováno v:
The Journal of Immunology. 208:47.17-47.17
Competent T cell development relies on efficient functioning of the thymus, which is extremely sensitive to acute and chronic insults, but has a remarkable ability to regenerate. We identified that cell-specific metabolic remodeling triggers key mole
Autor:
Cindy A. Evandy, Jarrod A Dudakov, Shahin Rafii, Kayla S. Hopwo, Sinéad Kinsella, Colton W. Smith, Kirsten Cooper, David W. Granadier, Lorenzo Iovino, Paul DeRoos
The molecular triggers of organotypic tissue repair are unknown. The thymus, which is the primary site of T cell development, is a model of tissue damage and regeneration as it is particularly sensitive to insult, but also has a remarkable capacity f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::00dc153475960fa8a09092b49a22252a
https://doi.org/10.1101/2020.08.31.275834
https://doi.org/10.1101/2020.08.31.275834
Autor:
Kayla S. Hopwo, Shahin Rafii, Paul DeRoos, Jarrod A Dudakov, Sinéad Kinsella, David W. Granadier, Kirsten Cooper, Colton W. Smith, Lorenzo Iovino, Cindy A. Evandy
Publikováno v:
Cell reports
Cell Reports, Vol 37, Iss 1, Pp 109789-(2021)
Cell Reports, Vol 37, Iss 1, Pp 109789-(2021)
SUMMARY The thymus, which is the primary site of T cell development, is particularly sensitive to insult but also has a remarkable capacity for repair. However, the mechanisms orchestrating regeneration are poorly understood, and delayed repair is co
Autor:
Kayla S. Hopwo, Cindy A. Evandy, Jarrod A Dudakov, Sinéad Kinsella, Kirsten Cooper, Paul DeRoos, Colton W. Smith, Reema Jain, Lorenzo Iovino
Publikováno v:
Blood. 136:28-28
T cell reconstitution after transplant is critically dependent on the thymus; an inverse relationship between a transplant recipient's age and their capacity to generate T lymphocytes (in particular CD4+T cells) has been found in several studies, and
Autor:
Sinéad Kinsella, Cindy A Evandy, Kirsten Cooper, Lorenzo Iovino, Reema Jain, Paul deRoos, Jarrod A Dudakov
Publikováno v:
The Journal of Immunology. 204:62.8-62.8
The thymus is extremely sensitive to damage, resulting in attenuated T cell reconstitution and failure to elicit appropriate responses to infection, cancer and immunization. Although the thymus has a remarkable regenerative capacity, the mechanisms u