Výsledky vyhledávání - "Cindy, Wintmolders"

Akademický článek

Passive immunotherapy with a novel antibody against 3pE-modified Aβ demonstrates potential for enhanced efficacy and favorable safety in combination with BACE inhibitor treatment in plaque-depositing mice

Autor: Jonathan Janssens, Bart Hermans, Marc Vandermeeren, Erio Barale-Thomas, Marianne Borgers, Roland Willems, Greet Meulders, Cindy Wintmolders, Dries Van den Bulck, Astrid Bottelbergs, Luc Ver Donck, Peter Larsen, Dieder Moechars, Wilson Edwards, Marc Mercken, Bianca Van Broeck

Publikováno v: Neurobiology of Disease, Vol 154, Iss , Pp 105365- (2021)

The imbalance between production and clearance of amyloid β (Aβ) peptides and their resulting accumulation in the brain is an early and crucial step in the pathogenesis of Alzheimer's disease (AD). Therefore, Aβ is strongly positioned as a promisi

Externí odkaz: https://doaj.org/article/7f712f2755314a818f17894b585c61e7

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Development and Characterization of Mouse-Specific Anti-Tau Monoclonal Antibodies: Relevance for Analysis of Murine Tau in Cerebrospinal Fluid

Autor: Dina Rodrigues Martins, Marc Vandermeeren, Kristof Van Kolen, Eddy Brepoels, Marianne Borgers, Cindy Wintmolders, Charlotte Delay, Astrid Bottelbergs, Marc Mercken, Clara Theunis

Publikováno v: Journal of Alzheimer's Disease. 93:151-167

Background: Clearance of tau seeds by immunization with tau antibodies is currently evaluated as therapeutic strategy to block the spreading of tau pathology in Alzheimer’s disease and other tauopathies. Preclinical evaluation of passive immunother

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::70737aef4ee676c561463bc553230abf
https://doi.org/10.3233/jad-221266

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Discovery and Functional Characterization of hPT3, a Humanized Anti-Phospho Tau Selective Monoclonal Antibody

Publikováno v: Journal of Alzheimer's Disease. 77:1397-1416

Background: As a consequence of the discovery of an extracellular component responsible for the progression of tau pathology, tau immunotherapy is being extensively explored in both preclinical and clinical studies as a disease modifying strategy for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb6c6c8a8bbb34392a44d1677aa443be
https://doi.org/10.3233/jad-200544

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Discovery of N-(4-[18F]Fluoro-5-methylpyridin-2-yl)isoquinolin-6-amine (JNJ-64326067), a New Promising Tau Positron Emission Tomography Imaging Tracer

Autor: Hartmuth C. Kolb, Stijn Wuyts, Cindy Wintmolders, Leenaerts Joseph Elisabeth, Astrid Bottelbergs, Lieven Declercq, Fengbin Song, Paula te Riele, Chunfang A. Xia, Laura Iturrino, Frederik J. R. Rombouts, José-Ignacio Andrés, Diederik Moechars, Jonas Mariën, Lu Chen, Guy Bormans, Rik Vandenberghe

Publikováno v: Journal of Medicinal Chemistry. 62:2974-2987

In Alzheimer’s disease, the density and spread of aggregated tau protein track well with neurodegeneration and cognitive decline, making the imaging of aggregated tau a compelling biomarker. A structure–activity relationship exploration around an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::686efa9b68450d4f1fd527db59acb24c
https://doi.org/10.1021/acs.jmedchem.8b01759

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Emergence of early alterations in network oscillations and functional connectivity in a tau seeding mouse model of Alzheimer’s disease pathology

Autor: K. Van Kolen, Wilhelmus Drinkenburg, John Kemp, Astrid Bottelbergs, T. Van De Casteele, A. Ahnaou, Nikolay V. Manyakov, Diederik Moechars, R. Biermans, L. Raeymaekers, Cindy Wintmolders

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Scientific Reports

Synaptic dysfunction and disconnectivity are core deficits in Alzheimer’s disease (AD), preceding clear changes in histopathology and cognitive functioning. Here, the early and late effects of tau pathology induction on functional network connectiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d522eb0face4c74f22482108070b6da
https://doaj.org/article/a9c5148746e4437dbedab4ea4cfaf87c

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Neural oscillations during cognitive processes in an App knock-in mouse model of Alzheimer’s disease pathology

Autor: Astrid Bottelbergs, Bart Hermans, Nikolay V. Manyakov, Cindy Wintmolders, M. Borgers, Gethin Davies, Detlef Balschun, Marijke De Bock, Wilhelmus Drinkenburg, Bianca Van Broeck, Clara Theunis, Sofia Jacob

Publikováno v: Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-19 (2019)
Scientific Reports, 9:16363. Nature Publishing Group

Multiple animal models have been created to gain insight into Alzheimer’s disease (AD) pathology. Among the most commonly used models are transgenic mice overexpressing human amyloid precursor protein (APP) with mutations linked to familial AD, res

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adbc34970396621e1168f1c6bb84d3ad
http://europepmc.org/articles/PMC6841667

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Discovery of N-(4-[

Autor: Frederik J R, Rombouts, Lieven, Declercq, José-Ignacio, Andrés, Astrid, Bottelbergs, Lu, Chen, Laura, Iturrino, Joseph E, Leenaerts, Jonas, Mariën, Fengbin, Song, Cindy, Wintmolders, Stijn, Wuyts, Chunfang A, Xia, Paula, Te Riele, Guy, Bormans, Rik, Vandenberghe, Hartmuth, Kolb, Diederik, Moechars

Publikováno v: Journal of medicinal chemistry. 62(6)

In Alzheimer's disease, the density and spread of aggregated tau protein track well with neurodegeneration and cognitive decline, making the imaging of aggregated tau a compelling biomarker. A structure-activity relationship exploration around an iso

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::04ed37a4764f6110413f18c159611c77
https://pubmed.ncbi.nlm.nih.gov/32069047

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