Volume-of-interest-based supervised cluster analysis for pseudo-reference region selection in [18F]DPA-714 PET imaging of the rat brain

Autor: Igor Fagner Vieira, Dieter Ory, Cindy Casteels, Fernando R. A. Lima, Koen Van Laere, Guy Bormans, Michel Koole

Publikováno v: EJNMMI Research, Vol 8, Iss 1, Pp 1-11 (2018)

Abstract Method Aim of this study was to automatically select a suitable pseudo-reference brain region for the accurate, non-invasive quantification of neuroinflammation in a rat brain using dynamic [18F]DPA-714 PET imaging. Procedures A supervised c

Externí odkaz: https://doaj.org/article/dc29051e252f4adc90e234356cf4591c

Increased P2X7 Receptor Binding Is Associated With Neuroinflammation in Acute but Not Chronic Rodent Models for Parkinson’s Disease

Autor: Melissa Crabbé, Anke Van der Perren, Ilse Bollaerts, Savannah Kounelis, Veerle Baekelandt, Guy Bormans, Cindy Casteels, Lieve Moons, Koen Van Laere

Publikováno v: Frontiers in Neuroscience, Vol 13 (2019)

The purinergic P2X7 receptor is a key mediator in (neuro)inflammation, a process that is associated with neurodegeneration and excitotoxicity in Parkinson’s disease (PD). Recently, P2X7 imaging has become possible with [11C]JNJ-(54173)717. We inves

Externí odkaz: https://doaj.org/article/6de7bfdce0b3466c98344755a0281f66

Role of the GLUT1 Glucose Transporter in Postnatal CNS Angiogenesis and Blood-Brain Barrier Integrity

Autor: Cindy Casteels, Tatiane Gorski, E. Dale Abel, Paola Gilardoni, Koen Van Laere, Melissa García-Caballero, Johanna Schaffenrath, Zheng Fan, Koen Veys, Joanna Kalucka, Annika Keller, Nadine V. Conchinha, Moheb Ghobrial, Gino De Smet, Thomas Wälchli, Peter Carmeliet, Anna Rita Cantelmo, Aline Seuwen, Sarah-Maria Fendt, Aileen Schroeter, Ann Bouché, Felix Schlegel, Katrien De Bock, Kim Vriens, Raphaela Ardicoglu, Melissa Crabbé, Ilse Julia Smolders

Publikováno v: Veys, K, Fan, Z, Ghobrial, M, Bouché, A, García-Caballero, M, Vriens, K, Conchinha, N V, Seuwen, A, Schlegel, F, Gorski, T, Crabbé, M, Gilardoni, P, Ardicoglu, R, Schaffenrath, J, Casteels, C, De Smet, G, Smolders, I, Van Laere, K, Abel, E D, Fendt, S M, Schroeter, A, Kalucka, J, Cantelmo, A R, Wälchli, T, Keller, A, Carmeliet, P & De Bock, K 2020, ' Role of the GLUT1 Glucose Transporter in Postnatal CNS Angiogenesis and Blood-Brain Barrier Integrity ', Circulation Research, vol. 127, no. 4, pp. 466-482 . https://doi.org/10.1161/CIRCRESAHA.119.316463
Circulation Research
Circulation Research, 127 (4)

Supplemental Digital Content is available in the text.
Rationale: Endothelial cells (ECs) are highly glycolytic and generate the majority of their energy via the breakdown of glucose to lactate. At the same time, a main role of ECs is to allow t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::596589d58c4f99427e7e2d5a97101838
https://doi.org/10.1161/circresaha.119.316463

A standardized method for the construction of tracer specific PET and SPECT rat brain templates: validation and implementation of a toolbox.

Autor: David Vállez Garcia, Cindy Casteels, Adam J Schwarz, Rudi A J O Dierckx, Michel Koole, Janine Doorduin

Publikováno v: PLoS ONE, Vol 10, Iss 3, p e0122363 (2015)

High-resolution anatomical image data in preclinical brain PET and SPECT studies is often not available, and inter-modality spatial normalization to an MRI brain template is frequently performed. However, this procedure can be challenging for tracers

Externí odkaz: https://doaj.org/article/5548e0bcbfb849a9a5d65fc67bc3a028

Optimization of multimodal imaging of mesenchymal stem cells using the human sodium iodide symporter for PET and Cerenkov luminescence imaging.

Autor: Esther Wolfs, Bryan Holvoet, Rik Gijsbers, Cindy Casteels, Scott J Roberts, Tom Struys, Michael Maris, Abdelilah Ibrahimi, Zeger Debyser, Koen Van Laere, Catherine M Verfaillie, Christophe M Deroose

Publikováno v: PLoS ONE, Vol 9, Iss 4, p e94833 (2014)

PurposeThe use of stably integrated reporter gene imaging provides a manner to monitor the in vivo fate of engrafted cells over time in a non-invasive manner. Here, we optimized multimodal imaging (small-animal PET, Cerenkov luminescence imaging (CLI

Externí odkaz: https://doaj.org/article/dc5576ed3cd3499983a3abef5a186f77