Výsledky vyhledávání - "Cinara Echart"

Data from Preclinical Studies in Support of Defibrotide for the Treatment of Multiple Myeloma and Other Neoplasias

Autor: Paul G. Richardson, Massimo Iacobelli, Kenneth C. Anderson, Mario Boccadoro, Antonio Palumbo, Maria Distaso, Beverly Teicher, Krishna Menon, Cinara Echart, Cecile Rouleau, Constantine S. Mitsiades

Purpose of the Study: Defibrotide, an orally bioavailable polydisperse oligonucleotide, has promising activity in hepatic veno-occlusive disease, a stem cell transplantation–related toxicity characterized by microangiopathy. The antithrombotic prop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37d14080f956e0421e6ef0840634c4f7
https://doi.org/10.1158/1078-0432.c.6517722

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Preclinical Studies in Support of Defibrotide for the Treatment of Multiple Myeloma and Other Neoplasias

Autor: Kenneth C. Anderson, Beverly A. Teicher, Massimo Iacobelli, Mario Boccadoro, Paul G. Richardson, Constantine S. Mitsiades, Cinara Echart, Maria Distaso, Antonio Palumbo, Krishna Menon, Cecile Rouleau

Publikováno v: Clinical Cancer Research. 15:1210-1221

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e96c5e0a9b3586be082353aef255d35a
https://doi.org/10.1158/1078-0432.ccr-08-1270

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Angiogenesis alteration by defibrotide: implications for its mechanism of action in severe hepatic veno-occlusive disease

Autor: Jin-Feng Zhou, Cy A. Stein, Massimo Iacobelli, Kanyalakshmi Ayyanar, Joongho Shin, Anatoliy M. Voskresenskiy, Paul G. Richardson, Luba Benimetskaya, Cinara Echart, Sijian Wu

Publikováno v: Blood. 112:4343-4352

Defibrotide (DF) is a mixture of porcine-derived single-stranded phosphodiester oligonucleotides (9-80-mer; average, 50-mer) that has been successfully used to treat severe hepatic veno-occlusive disease (sVOD) with multiorgan failure (MOF) in patien

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::800174f0e42739218b825dc93604cc14
https://doi.org/10.1182/blood-2008-04-149682

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The Rai (Shc C) adaptor protein regulates the neuronal stress response and protects against cerebral ischemia

Autor: Maria Grazia De Simoni, Alberto Gobbi, Giuliana Pelicci, Cinara Echart, Pier Giuseppe Pelicci, Flavia Troglio, Tony Pawson

Publikováno v: Proceedings of the National Academy of Sciences. 101:15476-15481

Rai (Shc C or N-Shc) is a neuron-specific member of the family of Shc-like adaptor proteins. Rai functions in the cytoplasmic propagation of Ret-dependent survival signals and regulates, in vivo , the number of sympathetic neurons. We report here a f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c55c774cbd3c629a6efe12ca824d6f0
https://doi.org/10.1073/pnas.0403283101

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The Powerful Neuroprotective Action of C1-Inhibitor on Brain Ischemia-Reperfusion Injury Does Not Require C1q

Autor: Claudio Storini, Emanuela Rossi, Luigi Bergamaschini, Maria Grazia De Simoni, Cinara Echart, Simone Pizzimenti

Publikováno v: Scopus-Elsevier

C1-inhibitor (C1-INH) is a major regulator of the complement classical pathway. Besides this action, it may also inhibit other related inflammatory systems. We have studied the effect of C1-INH in C57BL/6 mice with focal transient brain ischemia indu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcf033ecdda5f75828db343db07dacc0
https://doi.org/10.1016/s0002-9440(10)63744-3

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Padrões de polipeptídios de hordeína em relação à qualidade de malteação em variedades brasileiras de cevada

Autor: Cinara Echart-Almeida, Suzana Cavalli-Molina

Publikováno v: Pesquisa Agropecuária Brasileira, Vol 36, Iss 2, Pp 211-217 (2001)
Pesquisa Agropecuária Brasileira, Volume: 36, Issue: 2, Pages: 211-217, Published: FEB 2001
Pesquisa Agropecuária Brasileira v.36 n.2 2001
Pesquisa Agropecuária Brasileira
Empresa Brasileira de Pesquisa Agropecuária (Embrapa)
instacron:EMBRAPA

Since there is evidence that malting quality is related to the storage protein (hordein) fraction, in the present work the hordein polypeptide patterns from 13 barley (Hordeum vulgare L.) varieties of different malting quality were analysed in order

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67cfec38160b53f8ac9fe87297ace075
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-204X2001000200001

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Defibrotide blunts the prothrombotic effect of thalidomide on endothelial cells

Autor: Cinara Echart, Maria Distaso, Massimo Iacobelli, Jawed Fareed, Paul G. Richardson, Antonio Palumbo, S. Somaini

Publikováno v: Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis. 18(1)

Patients with multiple myeloma (MM) are at relatively high risk of developing thromboembolic events such deep venous thrombosis (DVT) where thalidomide therapy has been identified to increase this risk. Defibrotide (DF), a polydisperse oligonucleotid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2490192b63399a317bab014adef35c6
https://pubmed.ncbi.nlm.nih.gov/21733935

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The fibrinolytic mechanism of defibrotide: effect of defibrotide on plasmin activity

Autor: Barbara Graziadio, Laura Iris Ferro, Cinara Echart, Massimo Iacobelli, Jawed Fareed, Paul G. Richardson, Simona Somaini

Publikováno v: Blood coagulationfibrinolysis : an international journal in haemostasis and thrombosis. 20(8)

Fibrinolytic activity has been shown to be reduced in many vascular diseases, including hepatic veno-occlusive disease after stem cell transplantation, a microangiopathy characterized by sinusoidal endothelial cell injury. Defibrotide is a polydisper

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e008f90f6d92faffdff0cdba8370e8fb
https://pubmed.ncbi.nlm.nih.gov/19809307

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Defibrotide Counteracts the Modifications of Anti-Thrombotic Phenotype of Endothelial Cells Induced by Thalidomide

Autor: Mario Boccadoro, Barbara Graziadio, Constantine S. Mitsiades, Paul G. Richardson, Antonio Palumbo, Massimo Iacobelli, Cinzia Repice, Kenneth C. Anderson, Cinara Echart

Introduction: Patients with Multiple myeloma are at relatively high risk of developing thromboembolic events, usually deep vein thromboses (DVT). There are numerous contributing factors, including therapy, such as thalidomide, where DVT has been iden

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ecc696295502de38bfd68a00c22029e
http://hdl.handle.net/2318/117328

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