Caspase-8 contributes to angiogenesis and chemotherapy resistance in glioblastoma

Autor: Fianco, Giulia, Mongiardi, Maria Patrizia, Levi, Andrea, Luca, Teresa De, Desideri, Marianna, Trisciuoglio, Daniela, Bufalo, Donatella Del, Cinà, Irene, Benedetto, Anna Di, Mottolese, Marcella, Gentile, Antonietta, Centonze, Diego, Ferrè, Fabrizio, Barilà, Daniela

Publikováno v: eLife (2017). doi:10.7554/eLife.22593
info:cnr-pdr/source/autori:Fianco, Giulia; Fianco, Giulia; Mongiardi, Maria Patrizia; Levi, Andrea; Luca, Teresa De; Desideri, Marianna; Trisciuoglio, Daniela; Bufalo, Donatella Del; Cinà, Irene; Benedetto, Anna Di; Mottolese, Marcella; Gentile, Antonietta; Gentile, Antonietta; Centonze, Diego; Centonze, Diego; Ferrè, Fabrizio; Barilà, Daniela; Barilà, Daniela/titolo:Caspase-8 contributes to angiogenesis and chemotherapy resistance in glioblastoma/doi:10.7554%2FeLife.22593/rivista:eLife/anno:2017/pagina_da:/pagina_a:/intervallo_pagine:/volume
eLife, Vol 6 (2017)
eLife

Caspase-8 is a key player in extrinsic apoptosis and its activity is often downregulated in cancer. However, human Caspase-8 expression is retained in some tumors, including glioblastoma (GBM), suggesting that it may support cancer growth in these co

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http://hdl.handle.net/11585/615382

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Caspase-8 contributes to angiogenesis and chemotherapy resistance in glioblastoma.

Autor: Fianco G; Department of Biology, University of Rome Tor Vergata, Rome, Italy.; Laboratory of Cell Signaling, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Fondazione Santa Lucia, Rome, Italy., Mongiardi MP; Institute of Cell Biology and Neurobiology, Consiglio Nazionale delle Ricerche (CNR), Rome, Italy., Levi A; Institute of Cell Biology and Neurobiology, Consiglio Nazionale delle Ricerche (CNR), Rome, Italy., De Luca T; Preclinical Models and New Therapeutic Agents Unit, Research, Advanced Diagnostics and Technological Innovation Department, Regina Elena National Cancer Institute, Rome, Italy., Desideri M; Preclinical Models and New Therapeutic Agents Unit, Research, Advanced Diagnostics and Technological Innovation Department, Regina Elena National Cancer Institute, Rome, Italy., Trisciuoglio D; Preclinical Models and New Therapeutic Agents Unit, Research, Advanced Diagnostics and Technological Innovation Department, Regina Elena National Cancer Institute, Rome, Italy., Del Bufalo D; Preclinical Models and New Therapeutic Agents Unit, Research, Advanced Diagnostics and Technological Innovation Department, Regina Elena National Cancer Institute, Rome, Italy., Cinà I; Laboratory of Cell Signaling, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Fondazione Santa Lucia, Rome, Italy., Di Benedetto A; Pathology Department, Regina Elena National Cancer Institute, Rome, Italy., Mottolese M; Pathology Department, Regina Elena National Cancer Institute, Rome, Italy., Gentile A; Multiple Sclerosis Clinical and Research Center, Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.; Unit of Neurology and of Neurorehabilitation, IRCCS Istituto Neurologico Mediterraneo (INM) Neuromed, Pozzilli (IS), Italy., Centonze D; Multiple Sclerosis Clinical and Research Center, Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.; Unit of Neurology and of Neurorehabilitation, IRCCS Istituto Neurologico Mediterraneo (INM) Neuromed, Pozzilli (IS), Italy., Ferrè F; Department of Pharmacy and Biotechnology (FaBiT), University of Bologna, Bologna, Italy., Barilà D; Department of Biology, University of Rome Tor Vergata, Rome, Italy.; Laboratory of Cell Signaling, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Fondazione Santa Lucia, Rome, Italy.

Publikováno v: ELife [Elife] 2017 Jun 08; Vol. 6. Date of Electronic Publication: 2017 Jun 08.