Characteristics of the specific humoral response in patients with advanced solid tumors after active immunotherapy with a VEGF vaccine, at different antigen doses and using two distinct adjuvants

Autor: Javier Sánchez Ramírez, Yanelys Morera Díaz, Mónica Bequet-Romero, Francisco Hernández-Bernal, Katty-Hind Selman-Housein Bernal, Ana de la Torre Santos, Eduardo Rafael Santiesteban Álvarez, Yenima Martín Bauta, Cimara H. Bermúdez Badell, Josué de la Torre Pupo, Jorge V. Gavilondo, CENTAURO-2 Team of Investigators, Marta Ayala Avila

Publikováno v: BMC Immunology, Vol 18, Iss 1, Pp 1-20 (2017)

Abstract Background CIGB-247, a VSSP-adjuvanted VEGF-based vaccine, was evaluated in a phase I clinical trial in patients with advanced solid tumors (CENTAURO). Vaccination with the maximum dose of antigen showed an excellent safety profile, exhibite

Externí odkaz: https://doaj.org/article/1ac6def33bdd40cf874df2bf86aec797

Recombinant streptokinase vs hydrocortisone suppositories in acute hemorrhoids: A randomized controlled trial

Autor: Carmen M Valenzuela-Silva, José R Causa-García, Georgina Castellanos-Sierra, Francisco Hernández-Bernal, Pedro Lopez-Saura, Juan E Domínguez-Suárez, Odalys C Lazo-Diago, Karem M Catasús-Álvarez, Cimara H Bermúdez-Badell, Osmany Martínez-Serrano

Publikováno v: World journal of gastroenterology. 21(23)

To compare the efficacy and safety of recombinant streptokinase (rSK) vs hydrocortisone acetate-based suppositories in acute hemorrhoidal disease.A multicenter (11 sites), randomized (1:1:1), open, controlled trial with parallel groups was performed.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa08f8137091f5ab3f5169cf1c5c0dd0
https://pubmed.ncbi.nlm.nih.gov/26109819

Immunoglobulin E-dependent regulation of the CCR3 chemokine receptor by interferon-gamma in atopic asthmatics

Autor: Cimara H Bermúdez-Badell, Carmen M Valenzuela-Silva, Iraldo Bello-Rivero, Judith Rodríguez-Perez, Yanelda García-Vega, Elizabeth Blanco-Garcés, Pedro Lopez-Saura

Publikováno v: International archives of allergy and immunology. 148(3)

Background: The chemokine receptor CCR3 mediates the migration of cells that play an important role in the pathogenesis of asthma to inflammatory foci. Interferon (IFN)-γ is known to downregulate the expression of some chemokine receptors. Therefore

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4909ee7970ea07525a1f0cda0f477e62
https://pubmed.ncbi.nlm.nih.gov/18849613

Recombinant streptokinase vs hydrocortisone suppositories in acute hemorrhoids: A randomized controlled trial.

Autor: Hernández-Bernal F; Francisco Hernández-Bernal, Carmen M Valenzuela-Silva, Karem M Catasús-Álvarez, Odalys C Lazo-Diago, Cimara H Bermúdez-Badell, Pedro A López-Saura, Clinical Research Direction, Center for Genetic Engineering and Biotechnology, Havana 74110, Cuba., Castellanos-Sierra G; Francisco Hernández-Bernal, Carmen M Valenzuela-Silva, Karem M Catasús-Álvarez, Odalys C Lazo-Diago, Cimara H Bermúdez-Badell, Pedro A López-Saura, Clinical Research Direction, Center for Genetic Engineering and Biotechnology, Havana 74110, Cuba., Valenzuela-Silva CM; Francisco Hernández-Bernal, Carmen M Valenzuela-Silva, Karem M Catasús-Álvarez, Odalys C Lazo-Diago, Cimara H Bermúdez-Badell, Pedro A López-Saura, Clinical Research Direction, Center for Genetic Engineering and Biotechnology, Havana 74110, Cuba., Catasús-Álvarez KM; Francisco Hernández-Bernal, Carmen M Valenzuela-Silva, Karem M Catasús-Álvarez, Odalys C Lazo-Diago, Cimara H Bermúdez-Badell, Pedro A López-Saura, Clinical Research Direction, Center for Genetic Engineering and Biotechnology, Havana 74110, Cuba., Martínez-Serrano O; Francisco Hernández-Bernal, Carmen M Valenzuela-Silva, Karem M Catasús-Álvarez, Odalys C Lazo-Diago, Cimara H Bermúdez-Badell, Pedro A López-Saura, Clinical Research Direction, Center for Genetic Engineering and Biotechnology, Havana 74110, Cuba., Lazo-Diago OC; Francisco Hernández-Bernal, Carmen M Valenzuela-Silva, Karem M Catasús-Álvarez, Odalys C Lazo-Diago, Cimara H Bermúdez-Badell, Pedro A López-Saura, Clinical Research Direction, Center for Genetic Engineering and Biotechnology, Havana 74110, Cuba., Bermúdez-Badell CH; Francisco Hernández-Bernal, Carmen M Valenzuela-Silva, Karem M Catasús-Álvarez, Odalys C Lazo-Diago, Cimara H Bermúdez-Badell, Pedro A López-Saura, Clinical Research Direction, Center for Genetic Engineering and Biotechnology, Havana 74110, Cuba., Causa-García JR; Francisco Hernández-Bernal, Carmen M Valenzuela-Silva, Karem M Catasús-Álvarez, Odalys C Lazo-Diago, Cimara H Bermúdez-Badell, Pedro A López-Saura, Clinical Research Direction, Center for Genetic Engineering and Biotechnology, Havana 74110, Cuba., Domínguez-Suárez JE; Francisco Hernández-Bernal, Carmen M Valenzuela-Silva, Karem M Catasús-Álvarez, Odalys C Lazo-Diago, Cimara H Bermúdez-Badell, Pedro A López-Saura, Clinical Research Direction, Center for Genetic Engineering and Biotechnology, Havana 74110, Cuba.

Publikováno v: World journal of gastroenterology [World J Gastroenterol] 2015 Jun 21; Vol. 21 (23), pp. 7305-12.