Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Cillian O'Beirne"'
Publikováno v:
Antibiotics, Vol 12, Iss 2, p 348 (2023)
The urgent need to combat antibiotic resistance and develop novel antimicrobial therapies has triggered studies on novel metal-based formulations. N-heterocyclic carbene (NHC) complexes coordinate transition metals to generate a broad range of antica
Externí odkaz:
https://doaj.org/article/8c45e4773dac4a6aaa7557794e09e788
Autor:
Maria Gil-Moles, Cillian O'Beirne, Igor V. Esarev, Petra Lippmann, Matthias Tacke, Jindrich Cinatl, Denisa Bojkova, Ingo Ott
Publikováno v:
RSC Medicinal Chemistry.
Silver NHC complexes are potent uncompetitive inhibitors of SARS-CoV-2 PLpro with distinct antiviral efficacy.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35ac920e5aa0e7815ae43c9f30034945
https://doi.org/10.1039/d3md00067b
https://doi.org/10.1039/d3md00067b
Publikováno v:
Metallomics. 14
The antimicrobial properties of silver have been exploited for many centuries and continue to gain interest in the fight against antimicrobial drug resistance. The broad-spectrum activity and low toxicity of silver have led to its incorporation into
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::997e250ad99e2faef79ce24a88dcc52f
https://doi.org/10.1093/mtomcs/mfac046
https://doi.org/10.1093/mtomcs/mfac046
Autor:
David R. Andes, Magdalena Piatek, Cillian O'Beirne, Matthias Tacke, Siddappa A. Patil, Kevin Kavanagh, Jen Fossen, Marcus Baumann, Helge Müller-Bunz
Publikováno v:
Metallomics. 13
N-heterocyclic silver carbene compounds have been extensively studied and shown to be active agents against a host of pathogenic bacteria and fungi. By incorporating hypothesized virulence targeting substituents into NHC–silver systems via salt met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3d34045a1cdc9410842a1f02dcfb0d6
https://doi.org/10.1093/mtomcs/mfaa011
https://doi.org/10.1093/mtomcs/mfaa011
Autor:
Orla Howe, Jennie O'Loughlin, Cillian O'Beirne, Daniel Marhöfer, Silvia Napolitano, Matthias Tacke, Fahad Alkhathami, Marina Rubini, Megan O’Shaughnessy
Publikováno v:
Chembiochem : a European journal of chemical biology. 22(6)
Antibiotic resistance is a growing problem for public health and associated with increasing economic costs and mortality rates. Silver and silver-related compounds have been used for centuries due to their antimicrobial properties. In this work, we s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::452d760fe205a59be55f4dfd2b7c7f0e
https://pubmed.ncbi.nlm.nih.gov/33170522
https://pubmed.ncbi.nlm.nih.gov/33170522
Autor:
Helge Müller-Bunz, Cillian O'Beirne, Matthias Tacke, Oyinlola Dada, Hessah T. Althani, Kevin Kavanagh, Jennifer Cassidy, Xiangming Zhu, Yannick Ortin
Publikováno v:
Polyhedron. 149:95-103
The synthesis of six novel N-heterocyclic carbene silver(I) acetate complexes, three symmetrical and three non-symmetrical, were achieved using 4,5-diphenylimidazole to produce intermediate imidazolium salts and then obtain the corresponding silver(I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7665032d1ea70f6feb0f068aecaabf6
https://doi.org/10.1016/j.poly.2018.04.017
https://doi.org/10.1016/j.poly.2018.04.017
Autor:
Oyinlola Dada, Cillian O'Beirne, Matthias Tacke, Xiangming Zhu, Danielle Curran, Helge Müller-Bunz
Publikováno v:
Journal of Organometallic Chemistry. 840:30-37
The synthesis and biological evaluation of three gold pseudohalides and three gold thiolates, stabilised by the NHC ligand 1,3-dibenzyl-4,5-diphenyl-imidazol-2-ylidene (NHC*), in order to form stable gold(I) complexes is reported. Two separate proced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::37d712a59906791e41f3668b58141c9a
https://doi.org/10.1016/j.jorganchem.2017.03.050
https://doi.org/10.1016/j.jorganchem.2017.03.050
Autor:
Oyinlola Dada, Carsta Werner, Claudia Schmidt, Goar Sánchez-Sanz, Ingo Ott, Wolfgang Walther, Xiangming Zhu, Cillian O'Beirne, Matthias Tacke
Publikováno v:
Letters in Drug Design & Discovery. 14:125-134
The anticancer drug candidate 1,3-dibenzyl-4,5-diphenyl-imidazol-2-ylidene gold(I) chloride (NHC-AuCl) and its 2',3',4',6'-tetra-O-acetyl-β-D-glucopyranosyl-1'-thiolate derivative (NHC-AuSR), which is a potential ligand for glucose transporters, wer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3253c77818b7479fb74688a4a0c9fa1
https://doi.org/10.2174/1570180813666160826100158
https://doi.org/10.2174/1570180813666160826100158
Autor:
Helge Müller-Bunz, Kevin Kavanagh, Qinxi Ma, Cillian O'Beirne, Matthias Tacke, Xiangming Zhu, Nada F. Alhamad, Geraldine Butler
The rising threat of Antimicrobial Resistance (AMR) requires a novel approach to the treatment of infectious diseases. Covalently bonded silver, which has known antibacterial and antifungal properties and multiple mechanisms of action, may provide a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdc48421d926fe17a3b615d2d9cf5aa2
https://mural.maynoothuniversity.ie/14992/
https://mural.maynoothuniversity.ie/14992/
Publikováno v:
Acta Crystallographica Section C Structural Chemistry. 72:857-860
Gold monochloride and monobromide can be transformed into monomeric complexes by ligands such as CO, PPh3or Me2S, and such ligand-stabilized gold monochloride compounds have been investigated as catalysts, luminescent materials and anticancer drugs,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50c335b2792fab2f736a2ca75e4b631e
https://doi.org/10.1107/s2053229616015205
https://doi.org/10.1107/s2053229616015205