Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Cigdem Gelegen"'
Autor:
Cigdem Gelegen, Diana Cash, Katarina Ilic, Millie Sander, Eugene Kim, Camilla Simmons, Michel Bernanos, Joana Lama, Karen Randall, Jonathan T. Brown, Svjetlana Kalanj-Bognar, Samuel Cooke, K. Ray Chaudhuri, Clive Ballard, Paul Francis, Ivana Rosenzweig
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-7 (2022)
Abstract Rapid eye movement (REM) sleep behaviour disorder (RBD) is a REM parasomnia that often predicts the later occurrence of alpha-synucleinopathies. Variants in the gene encoding for the lysosomal enzyme glucocerebrosidase, GBA, strongly increas
Externí odkaz:
https://doaj.org/article/167e4c7fd5e44b8da63c18c8bd9f2a49
Autor:
William R Scott, Cigdem Gelegen, Keval Chandarana, Efthimia Karra, Ahmed Yousseif, Chloé Amouyal, Agharul I Choudhury, Fabrizio Andreelli, Dominic J Withers, Rachel L Batterham
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e59407 (2013)
Neuronatin (NNAT) is an endoplasmic reticulum proteolipid implicated in intracellular signalling. Nnat is highly-expressed in the hypothalamus, where it is acutely regulated by nutrients and leptin. Nnat pre-mRNA is differentially spliced to create N
Externí odkaz:
https://doaj.org/article/bad8868b8a9e432fbe8161c827391c3b
Autor:
Eneda Pjetri, Ria de Haas, Simone de Jong, Cigdem Gelegen, Hugo Oppelaar, Linda A W Verhagen, Marinus J C Eijkemans, Roger A Adan, Berend Olivier, Martien J Kas
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e50453 (2012)
Animal studies are very useful in detection of early disease indicators and in unravelling the pathophysiological processes underlying core psychiatric disorder phenotypes. Early indicators are critical for preventive and efficient treatment of progr
Externí odkaz:
https://doaj.org/article/fc7b1e65ba72473bb7f66435da962330
Autor:
D. Wasserman, S. Gullone, I. Duncan, M. Veronese, V. Gnoni, S. Higgins, A. Birdseye, E. Cigdem Gelegen, P.J. Goadsby, K. Ashkan, K.R. Chaudhuri, G. Tononi, P. Drakatos, I. Rosenzweig
Publikováno v:
Sleep Medicine. 100:S40-S41
Autor:
Danielle Wasserman, Silvia Gullone, Iain Duncan, Mattia Veronese, Valentina Gnoni, Sean Higgins, Adam Birdseye, Emine Cigdem Gelegen, Peter J. Goadsby, Keyoumars Ashkan, K. Ray Chaudhuri, Giulio Tononi, Panagis Drakatos, Ivana Rosenzweig
Publikováno v:
NPJ Parkinson's disease. 8(1)
Unlike sleep-walkers, patients with rapid-eye-movement-behaviour disorder (RBD) rarely leave the bed during the re-enactment of their dreams. RBD movements may be independent of spatial co-ordinates of the ‘outside-world’, and instead rely on (al
Autor:
Megan E. Drew, Rachel L. Batterham, Cigdem Gelegen, Efthimia Karra, Agharul I. Choudhury, Fabrizio Andreelli, Dominic J. Withers, Véronique Fauveau, Benoit Viollet, Keval Chandarana
Publikováno v:
Diabetes
OBJECTIVE Bariatric surgery causes durable weight loss. Gut hormones are implicated in obesity pathogenesis, dietary failure, and mediating gastrointestinal bypass (GIBP) surgery weight loss. In mice, we determined the effects of diet-induced obesity
Autor:
Martien J H Kas, Iain C. Campbell, David A. Collier, H. Oppelaar, Cigdem Gelegen, Eneda Pjetri
Publikováno v:
European Neuropsychopharmacology. 20:317-326
Excessive physical activity plays an important role in the progression of anorexia nervosa (AN) by accelerating weight loss during dietary restriction. To search for mechanisms underlying this trait, a panel of mouse chromosome substitution strains d
Publikováno v:
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. :309-317
Animal studies are important for the identification and functional characterization of the biological substrates underlying complex psychiatric disorders. However, novel insights into the relationship between the genome and behavior are needed for th
Autor:
J van den Heuvel, H. Oppelaar, Martien J H Kas, David A. Collier, Cigdem Gelegen, Iain C. Campbell, E Hessel
Publikováno v:
Genes, Brain and Behavior. 7:552-559
Increased physical activity and decreased motivation to eat are common features in anorexia nervosa. We investigated the development of these features and the potential implication of brain-derived neurotrophic factor (BDNF) and dopaminergic signalli
Autor:
Cigdem Gelegen, Martin E. Hess, William R. Scott, Keval Chandarana, Agharul I. Choudhury, Steven Millership, Ulrich Rüther, Rachel L. Batterham, Ahmed Yousseif, Queensta Millet, Dominic J. Withers, Efthimia Karra, Fernando Zelaya, Julian J. Emmanuel, Marianne T. Neary, Steven Williams, Megan E. Drew, Sean Manning, Jens C. Brüning, Owen O'Daly, Takashi Akamizu, Hiroshi Iwakura, Sofia Rahman
Publikováno v:
The Journal of clinical investigation. 123(8)
Polymorphisms in the fat mass and obesity-associated gene (FTO) are associated with human obesity and obesity-prone behaviors, including increased food intake and a preference for energy-dense foods. FTO demethylates N 6 -methyladenosine, a potential