Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Cierra N Casson"'
Autor:
Adriana R Mantegazza, Meghan A Wynosky-Dolfi, Cierra N Casson, Ariel J Lefkovith, Sunny Shin, Igor E Brodsky, Michael S Marks
Publikováno v:
PLoS Pathogens, Vol 13, Iss 12, p e1006785 (2017)
Bacterial pathogens that compromise phagosomal membranes stimulate inflammasome assembly in the cytosol, but the molecular mechanisms by which membrane dynamics regulate inflammasome activity are poorly characterized. We show that in murine dendritic
Externí odkaz:
https://doaj.org/article/a5393564b7f14e059427fb46cb885d79
Autor:
Cierra N Casson, Jessica L Doerner, Alan M Copenhaver, Jasmine Ramirez, Alicia M Holmgren, Mark A Boyer, Ingharan J Siddarthan, Sara H Rouhanifard, Arjun Raj, Sunny Shin
Publikováno v:
PLoS Pathogens, Vol 13, Iss 4, p e1006309 (2017)
Early responses mounted by both tissue-resident and recruited innate immune cells are essential for host defense against bacterial pathogens. In particular, both neutrophils and Ly6Chi monocytes are rapidly recruited to sites of infection. While neut
Externí odkaz:
https://doaj.org/article/c4c180f0208a4c9baa96b4fd6a36c7de
Autor:
Cierra N Casson, Alan M Copenhaver, Erin E Zwack, Hieu T Nguyen, Till Strowig, Bahar Javdan, William P Bradley, Thomas C Fung, Richard A Flavell, Igor E Brodsky, Sunny Shin
Publikováno v:
PLoS Pathogens, Vol 9, Iss 6, p e1003400 (2013)
Inflammasome activation is important for antimicrobial defense because it induces cell death and regulates the secretion of IL-1 family cytokines, which play a critical role in inflammatory responses. The inflammasome activates caspase-1 to process a
Externí odkaz:
https://doaj.org/article/6e70af77061a43699f1f4317eb5ba2ba
Autor:
Dong Wei, Kristin L. Horton, John Chen, Linlin Dong, Susan Chen, Kojo Abdul-Hadi, Ting Ting Zhang, Cierra N. Casson, Michael Shaw, Tsubasa Shiraishi, Brandon Wilkinson, Chengjie Ji, Mark G. Qian
Publikováno v:
Molecules, Vol 28, Iss 8, p 3311 (2023)
Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) is a check point protein expressed on the surface of T cells and plays a central role in regulating the immune response. In recent years, CTLA-4 has become a popular target for cancer immunotherapy
Externí odkaz:
https://doaj.org/article/98acaeab752f445abc9736539115085f
Autor:
Yosuke Sato, Cierra N. Casson, Atsushi Matsuda, James I. Kim, Judy Qiuju Shi, Shinji Iwasaki, Susan Chen, Brett Modrell, Chingkit Chan, Daniel Tavares, Douglas Austen, Koh Ida, Olga Tayber, Pyae Hein, Robert Comeau, Yafang Lin, Michael H. Shaw
Publikováno v:
Cancer Immunology, Immunotherapy. 71:2421-2431
Ipilimumab, a monoclonal antibody that recognizes cytotoxic T-lymphocyte associated protein 4 (CTLA-4), was the first immune checkpoint inhibitor approved by the FDA to treat metastatic melanoma patients. Multiple preclinical studies have proposed th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::487812ab51e1103050ebdd7de9df9697
https://doi.org/10.1007/s00262-022-03170-z
https://doi.org/10.1007/s00262-022-03170-z
Publikováno v:
Proceedings of the National Academy of Sciences. 112:7557-7562
The innate immune system is critical for host defense against microbial pathogens, yet many pathogens express virulence factors that impair immune function. Here, we used the bacterial pathogen Legionella pneumophila to understand how the immune syst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d06186f825586ebe273ed2aebedf81d
https://doi.org/10.1073/pnas.1501289112
https://doi.org/10.1073/pnas.1501289112
Autor:
Frances Taschuk, Janet Yu, Ronald G. Collman, Alan M. Copenhaver, Anjana Yadav, Hieu T. Nguyen, Sunny Shin, Cierra N. Casson, Valeria M. Reyes
Publikováno v:
Proceedings of the National Academy of Sciences. 112:6688-6693
Inflammasomes are critical for host defense against bacterial pathogens. In murine macrophages infected by gram-negative bacteria, the canonical inflammasome activates caspase-1 to mediate pyroptotic cell death and release of IL-1 family cytokines. A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f9b3fbaa42137b95db2073c07301dba
https://doi.org/10.1073/pnas.1421699112
https://doi.org/10.1073/pnas.1421699112
Autor:
Meghan A. Wynosky-Dolfi, Michael S. Marks, Adriana R. Mantegazza, Igor E. Brodsky, Sunny Shin, Ariel J Lefkovith, Cierra N. Casson
Publikováno v:
PLoS Pathogens, Vol 13, Iss 12, p e1006785 (2017)
PLoS Pathogens
PLoS Pathogens
Bacterial pathogens that compromise phagosomal membranes stimulate inflammasome assembly in the cytosol, but the molecular mechanisms by which membrane dynamics regulate inflammasome activity are poorly characterized. We show that in murine dendritic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::895a2de4e1410f6e73b6247333ca9149
https://doaj.org/article/a5393564b7f14e059427fb46cb885d79
https://doaj.org/article/a5393564b7f14e059427fb46cb885d79
Autor:
Sunny Shin, Sara H. Rouhanifard, Ingharan J. Siddarthan, Cierra N. Casson, Alan M. Copenhaver, Jessica L. Doerner, Jasmine Ramirez, Alicia M. Holmgren, Arjun Raj, Mark A. Boyer
Publikováno v:
PLoS Pathogens, Vol 13, Iss 4, p e1006309 (2017)
PLoS Pathogens
PLoS Pathogens
Early responses mounted by both tissue-resident and recruited innate immune cells are essential for host defense against bacterial pathogens. In particular, both neutrophils and Ly6Chi monocytes are rapidly recruited to sites of infection. While neut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e0f9914e6dd540abe64bcccc4badf45
http://europepmc.org/articles/PMC5404877?pdf=render
http://europepmc.org/articles/PMC5404877?pdf=render
Autor:
Hieu T. Nguyen, Matthew M. Duda, Thomas C. Fung, Sunny Shin, Cierra N. Casson, Craig R. Roy, Alan M. Copenhaver
Publikováno v:
Infection and immunity. 82(10)
Legionella pneumophila , an intracellular pathogen responsible for the severe pneumonia Legionnaires' disease, uses its dot/icm -encoded type IV secretion system (T4SS) to translocate effector proteins that promote its survival and replication into t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3ee419f2afe2f7dbc099978234c597d
https://pubmed.ncbi.nlm.nih.gov/25092908
https://pubmed.ncbi.nlm.nih.gov/25092908