Structure-Based Development of Novel Spiro-Piperidine ASH1L Inhibitors.

Autor: Huang G; Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109, United States., Stevens R; Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109, United States., Hucek DG; Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109, United States., Purohit T; Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109, United States., Li S; Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109, United States., Miao H; Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109, United States., Trost E; Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109, United States., Hewett G; Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109, United States., Clegg B; Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109, United States., Park SR; Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109, United States., Rajanayake K; College of Pharmacy, University of Michigan, Ann Arbor, Michigan 48109, United States., Wen B; College of Pharmacy, University of Michigan, Ann Arbor, Michigan 48109, United States., Sun D; College of Pharmacy, University of Michigan, Ann Arbor, Michigan 48109, United States., Cierpicki T; Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109, United States., Grembecka J; Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109, United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2024 Dec 16. Date of Electronic Publication: 2024 Dec 16.

Comparative studies of seafood and reptile α- and β-parvalbumins.

Autor: O'Malley A; Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan, USA.; Department of Chemistry and Biochemistry, University of South Carolina, Columbia, South Carolina, USA., Ray JM; Department of Pathology, University of Michigan, Ann Arbor, Michigan, USA., Kitlas P; Department of Experimental Allergology and Immunology, Medical University of Bialystok, Bialystok, Poland., Ruethers T; Tropical Futures Institute, James Cook University in Singapore, Singapore, Singapore.; Molecular Allergy Research Laboratory, College of Public Health, Medical and Veterinary Sciences, Australian Institute of Tropical Health and Medicine, James Cook University, Townsville, Queensland, Australia.; Centre for Food and Allergy Research, Murdoch Children's Research Institute, Melbourne, Victoria, Australia., Kapingidza AB; Department of Chemistry and Biochemistry, University of South Carolina, Columbia, South Carolina, USA., Cierpicki T; Department of Pathology, University of Michigan, Ann Arbor, Michigan, USA., Lopata A; Department of Experimental Allergology and Immunology, Medical University of Bialystok, Bialystok, Poland.; Tropical Futures Institute, James Cook University in Singapore, Singapore, Singapore.; Molecular Allergy Research Laboratory, College of Public Health, Medical and Veterinary Sciences, Australian Institute of Tropical Health and Medicine, James Cook University, Townsville, Queensland, Australia., Kowal K; Department of Experimental Allergology and Immunology, Medical University of Bialystok, Bialystok, Poland.; Department of Allergology and Internal Medicine, Medical University of Bialystok, Bialystok, Poland., Chruszcz M; Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan, USA.; Department of Chemistry and Biochemistry, University of South Carolina, Columbia, South Carolina, USA.

Publikováno v: Protein science : a publication of the Protein Society [Protein Sci] 2024 Dec; Vol. 33 (12), pp. e5226.

Ziftomenib in relapsed or refractory acute myeloid leukaemia (KOMET-001): a multicentre, open-label, multi-cohort, phase 1 trial.

Autor: Wang ES; Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA. Electronic address: eunice.wang@roswellpark.org., Issa GC; MD Anderson Cancer Center, Houston, TX, USA., Erba HP; Duke Cancer Institute, Durham, NC, USA., Altman JK; Northwestern University-Robert H Lurie Comprehensive Cancer Center, Chicago, IL, USA., Montesinos P; Hospital Universitari i Politècnic La Fe, Valencia, Spain., DeBotton S; Institut Gustave Roussy Service d'Hématologie Clinique, Paris, France., Walter RB; Fred Hutchinson Cancer Center, Seattle, WA, USA., Pettit K; University of Michigan, Ann Arbor, MI, USA., Savona MR; Vanderbilt-Ingram Cancer Center, Nashville, TN, USA., Shah MV; Mayo Clinic, Rochester, MN, USA., Kremyanskaya M; Icahn School of Medicine at Mount Sinai, New York, NY, USA., Baer MR; University of Maryland Greenebaum Comprehensive Cancer Center, Baltimore, MD, USA., Foran JM; Mayo Clinic Comprehensive Cancer Center, Mayo Clinic, Jacksonville, FL, USA., Schiller G; David Geffen School of Medicine at UCLA, Los Angeles, CA, USA., Adès L; Hôpital Saint-Louis (AP-HP) and Université Paris Cité and Centre d'Investigations Cliniques-Inserm CIC-1427, Paris, France., Heiblig M; Centre Hospitalier Lyon Sud, Lyon, France., Berthon C; Centre Hospitalo-Universitaire Lille, Lille, France., Peterlin P; CHU de Nantes-Hôtel-Dieu, Nantes, France., Rodríguez-Arbolí E; Department of Hematology, Hospital Universitario Virgen del Rocío, Seville Biomedicine Institute (IBiS/CSIC), University of Seville, Seville, Spain., Salamero O; Servei d'Hematologia de l'Hospital Vall d'Hebron i Unitat d'Hematología Experimental del Vall d'Hebron Institut d'Oncología, Facultat de Medicina, Universitat Autònoma de Barcelona, Barcelona, Spain., Patnaik MM; Mayo Clinic, Rochester, MN, USA., Papayannidis C; IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia 'Seràgnoli', Bologna, Italy., Grembecka J; University of Michigan, Ann Arbor, MI, USA., Cierpicki T; University of Michigan, Ann Arbor, MI, USA., Clegg B; University of Michigan, Ann Arbor, MI, USA., Ray J; University of Michigan, Ann Arbor, MI, USA., Linhares BM; University of Michigan, Ann Arbor, MI, USA., Nie K; Kura Oncology, Inc, San Diego, CA, USA., Mitra A; Kura Oncology, Inc, San Diego, CA, USA., Ahsan JM; Kura Oncology, Inc, San Diego, CA, USA., Tabachri M; Kura Oncology, Inc, San Diego, CA, USA., Soifer HS; Kura Oncology, Inc, San Diego, CA, USA., Corum D; Kura Oncology, Inc, San Diego, CA, USA., Leoni M; Kura Oncology, Inc, San Diego, CA, USA., Dale S; Kura Oncology, Inc, San Diego, CA, USA., Fathi AT; Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

Publikováno v: The Lancet. Oncology [Lancet Oncol] 2024 Oct; Vol. 25 (10), pp. 1310-1324.

Combination of menin and kinase inhibitors as an effective treatment for leukemia with NUP98 translocations.

Autor: Miao H; Department of Pathology, University of Michigan, Ann Arbor, MI, 48109, USA., Chen D; Department of Pathology, University of Michigan, Ann Arbor, MI, 48109, USA., Ropa J; Department of Microbiology and Immunology, Indiana University, School of Medicine, Indianapolis, IN, 46202, USA., Purohit T; Department of Pathology, University of Michigan, Ann Arbor, MI, 48109, USA., Kim E; Department of Pathology, University of Michigan, Ann Arbor, MI, 48109, USA., Sulis ML; Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA., Ferrando A; Institute for Cancer Genetics, Columbia University, New York, NY, 10032, USA.; Regeneron Genetics Center, Tarrytown, NY, 10591, USA., Cierpicki T; Department of Pathology, University of Michigan, Ann Arbor, MI, 48109, USA. tomaszc@umich.edu., Grembecka J; Department of Pathology, University of Michigan, Ann Arbor, MI, 48109, USA. jolantag@umich.edu.

Publikováno v: Leukemia [Leukemia] 2024 Aug; Vol. 38 (8), pp. 1674-1687. Date of Electronic Publication: 2024 Jun 18.

Applications of oxetanes in drug discovery and medicinal chemistry.

Autor: Huang G; Department of Pathology, University of Michigan, Ann Arbor, MI, 48109, USA. Electronic address: huanggu@umich.edu., Hucek D; Department of Pathology, University of Michigan, Ann Arbor, MI, 48109, USA., Cierpicki T; Department of Pathology, University of Michigan, Ann Arbor, MI, 48109, USA., Grembecka J; Department of Pathology, University of Michigan, Ann Arbor, MI, 48109, USA.

Publikováno v: European journal of medicinal chemistry [Eur J Med Chem] 2023 Dec 05; Vol. 261, pp. 115802. Date of Electronic Publication: 2023 Sep 11.