Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Cicely K. Macnamara"'
Publikováno v:
GigaByte (2024)
The extracellular matrix, composed of macromolecules like collagen fibres, provides structural support to cells and acts as a barrier that metastatic cells degrade to spread beyond the primary tumour. While agent-based frameworks, such as PhysiCell,
Externí odkaz:
https://doaj.org/article/d780e6db45f8470b820d0d325b157d9b
Autor:
Cicely K. Macnamara
Publikováno v:
Computational and Systems Oncology, Vol 1, Iss 2, Pp n/a-n/a (2021)
Abstract Once cancer is initiated, with normal cells mutated into malignant ones, a solid tumour grows, develops and spreads within its microenvironment invading the local tissue; the disease progresses and the cancer cells migrate around the body le
Externí odkaz:
https://doaj.org/article/3f5c5b7f14594dddba41b9f18f1b3024
Autor:
Ján Eliaš, Cicely K. Macnamara
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 19, p 10590 (2021)
No gene has garnered more interest than p53 since its discovery over 40 years ago. In the last two decades, thanks to seminal work from Uri Alon and Ghalit Lahav, p53 has defined a truly synergistic topic in the field of mathematical biology, with a
Externí odkaz:
https://doaj.org/article/0477296a819642939bcff81522a470d6
Publikováno v:
Journal of Theoretical Biology. 468:27-44
Funding: EPSRC Grant No. EP/N014642/1 (EPSRC Centre for Multiscale Soft Tissue Mechanics - With Application to Heart & Cancer) (MAJC,CKM). Transcription factors are important molecules which control the levels of mRNA and proteins within cells by mod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e01bcc23f652ec7f62bb3fa84d69eee2
https://doi.org/10.1016/j.jtbi.2019.02.003
https://doi.org/10.1016/j.jtbi.2019.02.003
Funding: MAJC and CKM gratefully acknowledge the support of EPSRC Grant No. EP/N014642/1 (EPSRC Centre for Multiscale Soft Tissue Mechanics - With Application to Heart & Cancer). The term cancer covers a multitude of bodily diseases, broadly categori
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9900e000d1ea1c16753219e328588fd6
Publikováno v:
Mathematical Modelling of Natural Phenomena. 11:65-85
Despite mounting evidence that oncolytic viruses can be effective in treating cancer, understanding the details of the interactions between tumour cells, oncolytic viruses and immune cells that could lead to tumour control or tumour escape is still a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea0a301e486987b0a901207a037bb12e
https://doi.org/10.1051/mmnp/201611505
https://doi.org/10.1051/mmnp/201611505
Autor:
Raluca Eftimie, Cicely K. Macnamara
Publikováno v:
Journal of Theoretical Biology. 377:1-9
R.E. acknowledges support from an Engineering and Physical Sciences Research Council (UK) First Grant number EP/K033689/1 The main priority when designing cancer immuno-therapies has been to seek viable biological mechanisms that lead to permanent ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::275453ff63381536fdddd267588f6180
https://doi.org/10.1016/j.jtbi.2015.04.004
https://doi.org/10.1016/j.jtbi.2015.04.004
Signal transduction pathways play a major role in many important aspects of cellular function e.g. cell division, apoptosis. One important class of signal transduction pathways is gene regulatory networks (GRNs). In many GRNs, proteins bind to gene s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::619384db8de6881758959f09425efc6b
https://eprints.gla.ac.uk/251340/1/251340.pdf
https://eprints.gla.ac.uk/251340/1/251340.pdf
Autor:
Mark A. J. Chaplain, Maciej Cytowski, Cicely K. Macnamara, Elaine I. Mitchell, Zuzanna Szymańska
Publikováno v:
Bulletin of mathematical biology. 80(5)
In this paper, we present two mathematical models related to different aspects and scales of cancer growth. The first model is a stochastic spatiotemporal model of both a synthetic gene regulatory network (the example of a three-gene repressilator is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6251c7b2917a73f62f7046e4106ca92
https://pubmed.ncbi.nlm.nih.gov/28634857
https://pubmed.ncbi.nlm.nih.gov/28634857
Publikováno v:
Journal of theoretical biology. 407
Gene regulatory networks (GRNs) play an important role in maintaining cellular function by correctly timing key processes such as cell division and apoptosis. GRNs are known to contain similar structural components, which describe how genes and prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc3c8abd770420fcbb9f96e82c5f258f
https://pubmed.ncbi.nlm.nih.gov/27449790
https://pubmed.ncbi.nlm.nih.gov/27449790