Výsledky vyhledávání - "Cicely, Berg"

Proposed New Addition to 3Rs for Ethical and Humane Use of Rats in Pharmacokinetic Studies – ‘Recycle’

Autor: Chaung Lu, Ji Zhang, Suresh K. Balani, Frank W. Lee, Kym Cardoza, Cicely Berg

Publikováno v: Drug Metabolism Letters. 2:193-197

The great emphasis on ethical and humane treatment of animals in biomedical research has culminated in the promulgation of the rule of 3Rs - Replacement, Reduction, and Refinement. We have proposed an addition to the 3Rs - a fourth R for Recycling th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ac0345331030a4cd749fed85102db9b2
https://doi.org/10.2174/187231208785425827

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Prediction of Pharmacokinetic Drug-Drug Interactions Using Human Hepatocyte Suspension in Plasma and Cytochrome P450 Phenotypic Data. II. In Vitro-in Vivo Correlation with Ketoconazole

Autor: Chuang, Lu, Panos, Hatsis, Cicely, Berg, Frank W, Lee, Suresh K, Balani

Publikováno v: Drug Metabolism and Disposition. 36:1255-1260

Traditional cytochrome P450 (P450) based drug-drug interaction (DDI) predictions are based on the ratio of an inhibitor's physiological concentration [I] and its inhibition constant K(i). Determining [I] at the enzymatic site, although critical for p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a0848623515340c1dbc5ea7dc318e7a
https://doi.org/10.1124/dmd.107.018796

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Proposed new addition to 3Rs for ethical and humane use of rats in pharmacokinetic studies--'Recycle'

Autor: Suresh K, Balani, Chuang, Lu, Kym, Cardoza, Cicely, Berg, Ji, Zhang, Frank W, Lee

Publikováno v: Drug metabolism letters. 2(3)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0ed3e0d2729bcc7ed5262c8460fe4f03
https://pubmed.ncbi.nlm.nih.gov/19356093

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Prediction of pharmacokinetic drug-drug interactions using human hepatocyte suspension in plasma and cytochrome P450 phenotypic data. III. In vitro-in vivo correlation with fluconazole

Autor: Suresh K. Balani, Frank W. Lee, Shimoga R. Prakash, Chuang Lu, Cicely Berg

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 36(7)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d2b09d345ffd0148c09666600bbd639
https://pubmed.ncbi.nlm.nih.gov/18381488

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