Transcriptomic profiling reveals three molecular phenotypes of adenocarcinoma at the gastroesophageal junction

Autor: Bornschein, J, Wernisch, L, Secrier, M, Miremadi, A, Perner, J, MacRae, S, O'Donovan, M, Newton, R, Menon, S, Bower, L, Eldridge, MD, Devonshire, G, Cheah, C, Turkington, R, Hardwick, RH, Selgrad, M, Venerito, M, Malfertheiner, P, Fitzgerald, RC, Noorani, A, Elliott, RF, Edwards, PAW, Grehan, N, Nutzinger, B, Crawte, J, Chettouh, H, Contino, G, Li, X, Gregson, E, Zeki, S, De la Rue, R, Malhotra, S, Tavare, S, Lynch, AG, Smith, ML, Davies, J, Crichton, C, Carroll, N, Safranek, P, Hindmarsh, A, Sujendran, V, Hayes, SJ, Ang, Y, Preston, SR, Oakes, S, Bagwan, I, Save, V, Skipworth, RJE, Hupp, TR, O'Neill, JR, Tucker, O, Beggs, A, Taniere, P, Puig, S, Underwood, TJ, Noble, F, Owsley, J, Barr, H, Shepherd, N, Old, O, Lagergren, J, Gossage, J, Davies, A, Chang, F, Zylstra, J, Goh, V, Ciccarelli, FD, Sanders, G, Berrisford, R, Harden, C, Bunting, D, Lewis, M, Cheong, E, Kumar, B, Parsons, SL, Soomro, I, Kaye, P, Saunders, J, Lovat, L, Haidry, R, Eneh, V, Igali, L, Scott, M, Sothi, S, Suortamo, S, Lishman, S, Hanna, GB, Peters, CJ, Grabowska, A

Publikováno v: on behalf of the OCCAMS Consortium 2019, ' Transcriptomic profiling reveals three molecular phenotypes of adenocarcinoma at the gastroesophageal junction ', International Journal of Cancer . https://doi.org/10.1002/ijc.32384
International Journal of Cancer

Cancers occurring at the gastroesophageal junction (GEJ) are classified as predominantly esophageal or gastric, which is often difficult to decipher. We hypothesized that the transcriptomic profile might reveal molecular subgroups which could help to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::247888413c0d73e27a41f5f76d2e9dd0
https://doi.org/10.1002/ijc.32384

The landscape of selection in 551 Esophageal Adenocarcinomas defines genomic biomarkers for the clinic

Autor: Frankell, AM, Jammula, S, Li, X, Contino, G, Killcoyne, S, Abbas, S, Perner, J, Bower, L, Devonshire, G, Cocks, E, Grehan, N, Mok, J, O'Donovan, M, MacRae, S, Eldridge, MD, Tavare, S, Fitzgerald, RC, Noorani, A, Edwards, PAW, Grehanl, N, Nutzinger, B, Hughes, CI, Fidziukiewicz, E, Northrop, A, De la Rue, R, Katz-Summercorn, A, Loureda, D, Miremadi, A, Malhotra, S, Tripathi, M, Lynch, AG, Eldridge, M, Secrier, M, Davies, J, Crichton, C, Carro, N, Safranek, P, Hindmarsh, A, Sujendran, V, Hayes, SJ, Ang, Y, Sharrocks, A, Preston, SR, Oakes, S, Bagwan, I, Save, V, Skipworth, RJE, Hupp, TR, ONeill, JR, Tucker, O, Beggs, A, Taniere, P, Puig, S, Underwood, T, Walker, RC, Grace, BL, Barr, H, Shepherd, N, Old, O, Lagergren, J, Gossage, J, Davies, A, Chang, F, Zylstra, J, Mahadeva, U, Goh, V, Ciccarelli, FD, Sanders, G, Berrisford, R, Harden, C, Lewis, M, Cheong, E, Kumar, B, Parsons, SL, Soomro, I, Kaye, P, Saunders, J, Lovat, L, Haidry, R, Igali, L, Scott, M, Sothi, S, Suortamo, S, Lishman, S, Hanna, GB, Moorthy, K, Peters, CJ, Grabowska, A, Turkington, R, McManus, D, Coleman, H, Khoo, D, Fickling, W

Publikováno v: Nature genetics

Esophageal Adenocarcinoma (EAC) is a poor prognosis cancer type with rapidly rising incidence. Our understanding of genetic events which drive EAC development is limited and there are few molecular biomarkers for prognostication or therapeutics. We h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99929338d90f78f1c05cc30099825dcb
https://doi.org/10.1101/310029

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