Výsledky vyhledávání - "Ciby J Abraham"

Akademický článek

Exposure to MIV-150 from a high-dose intravaginal ring results in limited emergence of drug resistance mutations in SHIV-RT infected rhesus macaques.

Publikováno v: PLoS ONE, Vol 9, Iss 2, p e89300 (2014)

When microbicides used for HIV prevention contain antiretroviral drugs, there is concern for the potential emergence of drug-resistant HIV following use in infected individuals who are either unaware of their HIV infection status or who are aware but

Externí odkaz: https://doaj.org/article/b1f84d839f2a4832b1c088e64864c11d

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Akademický článek

An antiretroviral/zinc combination gel provides 24 hours of complete protection against vaginal SHIV infection in macaques.

Autor: Jessica Kenney, Meropi Aravantinou, Rachel Singer, Mayla Hsu, Aixa Rodriguez, Larisa Kizima, Ciby J Abraham, Radhika Menon, Samantha Seidor, Anne Chudolij, Agegnehu Gettie, James Blanchard, Jeffrey D Lifson, Michael Piatak, Jose A Fernández-Romero, Thomas M Zydowsky, Melissa Robbiani

Publikováno v: PLoS ONE, Vol 6, Iss 1, p e15835 (2011)

Repeated use, coitus-independent microbicide gels that do not contain antiretroviral agents also used as first line HIV therapy are urgently needed to curb HIV spread. Current formulations require high doses (millimolar range) of antiretroviral drugs

Externí odkaz: https://doaj.org/article/c33767af459e4d63b82956f69b733d81

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Zinc Acetate/Carrageenan Gels Exhibit Potent Activity In Vivo against High-Dose Herpes Simplex Virus 2 Vaginal and Rectal Challenge

Autor: Thomas M. Zydowsky, Ninochka Jean-Pierre, Brian E. Ford, Ciby J. Abraham, Samantha Seidor, Larisa Kizima, Jennifer J. Peters, José A. Fernández-Romero, Aixa Rodriguez, Radhika Menon, Melissa Robbiani, Pedro Gil, David F. Katz, Othell Begay

Publikováno v: Antimicrobial Agents and Chemotherapy. 56:358-368

Topical microbicides that block the sexual transmission of HIV and herpes simplex virus 2 (HSV-2) are desperately needed to reduce the incidence of HIV infections worldwide. Previously we completed phase 3 testing of the carrageenan-based gel Carragu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17da567afe4363b2454dbb48d2ae73ef
https://doi.org/10.1128/aac.05461-11

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Identification of Personal Lubricants That Can Cause Rectal Epithelial Cell Damage and Enhance HIV Type 1 Replicationin Vitro

Autor: Samantha Seidor, Ciby J. Abraham, Aixa Rodriguez, Brian E. Ford, Anne Chudolij, Ninochka Jean-Pierre, David F. Katz, Marcus H. Henderson, Othell Begay, José A. Fernández-Romero, Melissa Robbiani, Thomas M. Zydowsky

Publikováno v: AIDS Research and Human Retroviruses. 27:1019-1024

Over-the-counter personal lubricants are used frequently during vaginal and anal intercourse, but they have not been extensively tested for biological effects that might influence HIV transmission. We evaluated the in vitro toxicity anti-HIV-1 activi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f24caf43c72dc6e268cd8fb0719d2de
https://doi.org/10.1089/aid.2010.0252

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A MIV-150/zinc acetate gel inhibits SHIV-RT infection in macaque vaginal explants

Publikováno v: PLoS ONE, Vol 9, Iss 9, p e108109 (2014)
PLoS ONE

To extend our observations that single or repeated application of a gel containing the NNRTI MIV-150 (M) and zinc acetate dihydrate (ZA) in carrageenan (CG) (MZC) inhibits vaginal transmission of simian/human immunodeficiency virus (SHIV)-RT in macaq

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecbfbcb06e935ed6199627a9d2b02e84
http://europepmc.org/articles/PMC4178065?pdf=render

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An Anionic Nucleophilic Catalyst System for the Diastereoselective Synthesis of trans-β-Lactams

Autor: Ciby J. Abraham, Anthony Weatherwax, Thomas Lectka

Publikováno v: Organic Letters. 7:3461-3463

Trans-disubstituted beta-lactams show increasing utility and prominence in numerous pharmaceutical applications, making their asymmetric synthesis an attractive goal for chemists. We introduce an anionic, nucleophilic catalyst system that provides an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd1581fd5e0ba0c1ac41adfc245b6ad9
https://doi.org/10.1021/ol0511070

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Exposure to MIV-150 from a high-dose intravaginal ring results in limited emergence of drug resistance mutations in SHIV-RT infected rhesus macaques

Publikováno v: PLoS ONE
PLoS ONE, Vol 9, Iss 2, p e89300 (2014)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c76d100778b02892f4b2f5e841aae582
https://pubmed.ncbi.nlm.nih.gov/24586674

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An antiretroviral/zinc combination gel provides 24 hours of complete protection against vaginal SHIV infection in macaques

Autor: Radhika Menon, Mayla Hsu, Rachel Singer, Jessica Kenney, Anne Chudolij, Melissa Robbiani, Aixa Rodriguez, Meropi Aravantinou, Samantha Seidor, Ciby J. Abraham, Agegnehu Gettie, Michael Piatak, Thomas M. Zydowsky, Larisa Kizima, James Blanchard, José A. Fernández-Romero, Jeffrey D. Lifson

Publikováno v: PLoS ONE, Vol 6, Iss 1, p e15835 (2011)
PLoS ONE

Background Repeated use, coitus-independent microbicide gels that do not contain antiretroviral agents also used as first line HIV therapy are urgently needed to curb HIV spread. Current formulations require high doses (millimolar range) of antiretro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3f55c6fc9d944b7a695b9f99155ce75
http://europepmc.org/articles/PMC3016413?pdf=render

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