Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Cibele Sabido-David"'
Publikováno v:
Expert Opinion on Investigational Drugs. 13:1249-1261
Chronic pain affects a large percentage of the population, representing a socio-economic burden. Current treatments are characterised by suboptimal efficacy and/or side effects that limit their use. Among several approaches to treating chronic pain,
Autor:
John Kendrick-Jones, S. Criddle, Birgit Brandmeier, David R. Trentham, Seth C. Hopkins, Cibele Sabido-David, Malcolm Irving, Yale E. Goldman, U. A. van der Heide, John E. T. Corrie, Roisean E. Ferguson, Robert E. Dale
Publikováno v:
Nature. 400:425-430
A new method is described for measuring motions of protein domains in their native environment on the physiological timescale. Pairs of cysteines are introduced into the domain at sites chosen from its static structure and are crosslinked by a bifunc
Autor:
Susan Lowey, Yale E. Goldman, Cibele Sabido-David, Lakshmi D. Saraswat, Seth C. Hopkins, Malcolm Irving
Publikováno v:
Journal of Molecular Biology. 279:387-402
Changes in the orientation of the myosin regulatory light chain (RLC) in single muscle fibres were measured using polarised fluorescence from acetamidotetramethylrhodamine (ATR). Mutants of chicken skeletal RLC containing single cysteine residues at
Autor:
Yale E. Goldman, Roisean E. Ferguson, Robert E. Dale, David R. Trentham, Seth C. Hopkins, Cibele Sabido-David, Uulke A. van der Heide, Birgit Brandmeier, Malcolm Irving, John Kendrick-Jones, John E. T. Corrie
Publikováno v:
Journal of molecular biology. 318(5)
Structural changes in myosin power many types of cell motility including muscle contraction. Tilting of the myosin light chain domain (LCD) seems to be the final step in transducing the energy of ATP hydrolysis, amplifying small structural changes ne
Autor:
Derk J. Bergsma, Philip G. Szekeres, Cibele Sabido-David, Dana S. Levy, Alison I. Muir, Shelagh Wilson, Gillian I. Rennie, Jon K. Chambers, Israel S. Gloger, Robert S. Ames, Jeffrey Hill, Malcolm Duckworth, Paul R. Murdock
Publikováno v:
The Journal of biological chemistry. 276(23)
Melanin-concentrating hormone (MCH) is involved in the regulation of feeding and energy homeostasis. Recently, a 353-amino acid splice variant form of the human orphan receptor SLC-1 () (hereafter referred to as MCH(1)) was identified as an MCH recep
Autor:
Jeffrey C. Jerman, Darren Smart, Roderick A. Porter, John G. Darker, Cibele Sabido-David, Drake S. Eggleston, Stephen J. Brough
Publikováno v:
Bioorganicmedicinal chemistry letters. 11(5)
Truncated peptide analogues of orexin-A were prepared and their biological activity assesed at the orexin-1 receptor. Progressive N-terminal deletions identified the minimum C-terminal sequence required for maintaining a significant agonist effect, w
Publikováno v:
Biophysical journal. 74(6)
Fluorescence polarization was used to examine orientation changes of two rhodamine probes bound to myosin heads in skeletal muscle fibers. Chicken gizzard myosin regulatory light chain (RLC) was labeled at Cys108 with either the 5- or the 6-isomer of
Autor:
Birgit Brandmeier, John E. T. Corrie, David R. Trentham, James S. Craik, Malcolm Irving, Cibele Sabido-David
Publikováno v:
Biophysical journal. 74(6)
The regulatory light chain (RLC) from chicken gizzard myosin was covalently modified on cysteine 108 with either the 5- or 6-isomer of iodoacetamidotetramethylrhodamine (IATR). Labeled RLCs were purified by fast protein liquid chromatography and char
Autor:
John Kendrick-Jones, Uulke A. van der Heide, Malcolm Irving, John E. T. Corrie, Cibele Sabido-David, Seth C. Hopkins, Robert E. Dale, Birgit Brandmeier, Yale E. Goldman, Roisean E. Ferguson, David R. Trentham
Publikováno v:
Journal of Molecular Biology. 322:479-480