Coumestrol pre‐treatment improves spatial learning and memory deficits following transient cerebral ischemia recruiting hippocampal GluR2 AMPA receptors

Autor: Cibele Canal Castro, Aline Souza Pagnussat, Carolina Demarchi Munhoz, Carlos Alexandre Netto

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Transient global ischemia is a leading cause of learning and memory dysfunction and induces a pattern of delayed neuronal death in the CA1 subfield of the hippocampus by down-regulating GluR2 mRNA AMPA receptors in this cerebral area. This study soug

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14e8bbaace50d17eea2e8eeac01e559b
https://doi.org/10.1002/hipo.23418

Coumestrol treatment prevents Na+, K+-ATPase inhibition and affords histological neuroprotection to male rats receiving cerebral global ischemia

Autor: Fernanda R. Machado, Angela T. S. Wyse, Aline de Souza Pagnussat, Carlos Alexandre Netto, Maira J. da Cunha, N. R. Moura, Cibele Canal Castro

Publikováno v: Neurological Research. 36:198-206

In this study, we investigated the possible mechanisms underlying the neuroprotective effects of coumestrol, a potent isoflavonoid with antioxidant activities and binding affinities for both estrogen receptors (ER) ER-alpha and ER-beta that are compa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b02260bda5918735afbf2cf9867020e
https://doi.org/10.1179/1743132813y.0000000286

Clozapine and Olanzapine but not Risperidone Impair the Pre-Frontal Striatal System in relation to Egocentric Spatial Orientation in a Y-Maze

Autor: Ivan Izquierdo, Adriana Simon Coitinho, Werner J. Schmidt, Eleonora Araujo dos Reis-Lunardelli, Cibele Canal Castro

Publikováno v: Current Neurovascular Research. 4:235-239

Many studies indicate a dissociation between two forms of orientation: allocentric orientation, in which an organism orients on the basis of cues external to the organism, and egocentric spatial orientation (ESO) by which an organism orients on the b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4be79da29564abab31bba1f6414a78c4
https://doi.org/10.2174/156720207782446379

Effects of an acute treatment with L-thyroxine on memory, habituation, danger avoidance, and on Na+, K+ -ATPase activity in rat brain

Autor: Maria Rosana Ramirez, Myriam Fortes Perrenoud, Caren Serra Bavaresco, Laura Schumacher Schuh da Trindade, Cibele Canal Castro, Adriana Simon Coitinho, Ivan Izquierdo, Angela T. S. Wyse, Eleonora Araujo dos Reis-Lunardelli, João José Freitas Sarkis

Publikováno v: Current neurovascular research. 4(4)

Thyroid hormones (THs) have a relevant action on brain development and maintenance. By using an acute treatment to induce a hyperthyroid animal model, we aimed at investigating the effect of an altered THs levels on learning and memory and on the act

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5afdd771aa11357c2154806b7cde227
https://pubmed.ncbi.nlm.nih.gov/18045151

Coumestrol has neuroprotective effects before and after global cerebral ischemia in female rats

Autor: N. R. Moura, Lenir Orlandi, Anne M. Etgen, Carlos Alexandre Netto, Cibele Canal Castro, Aline de Souza Pagnussat, Paulo Valdeci Worm

Publikováno v: Brain Research. :82-90

Global ischemia arising during cardiac arrest or cardiac surgery causes highly selective, delayed death of hippocampal CA1 neurons. Phytoestrogens are naturally occurring plant-derived compounds that are present in the human diet and are considered s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f872cb4930f6a68b0358419a00f14fdd