Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Ciaran O'Riain"'
Autor:
Roshni D. Kalachand, Ciaran O’Riain, Sinead Toomey, Aoife Carr, Kirsten M. Timms, Sharon O’Toole, Stephen Madden, Mark Bates, John J. O’Leary, Noreen Gleeson, Dearbhaile O’Donnell, Liam Grogan, Oscar Breathnach, Angela Farrelly, Britta Stordal, Bryan T. Hennessy
Publikováno v:
Obstetrics & Gynecology Science, Vol 63, Iss 5, Pp 643-654 (2020)
Objective The therapeutic benefits of poly(ADP-ribose) polymerase inhibitors highlight the need to evaluate BRCA1/2 defects in tubal/ovarian cancer (OC). We sought to determine the pattern and disease characteristics associated with tumor BRCA1/2 mut
Externí odkaz:
https://doaj.org/article/6cbb4fc095ea435da4eec3de790092e5
Autor:
Noreen Gleeson, John J. O'Leary, Dearbhaile M. O'Donnell, Aoife Carr, Britta K. Stordal, Liam Grogan, Stephen F. Madden, Angela M. Farrelly, Kirsten Timms, Mark Bates, Sinead Toomey, Roshni Kalachand, Bryan T. Hennessy, Ciaran O'Riain, Sharon O'Toole, Oscar S. Breathnach
Publikováno v:
Obstetrics & Gynecology Science
Obstetrics & Gynecology Science, Vol 63, Iss 5, Pp 643-654 (2020)
Obstetrics & Gynecology Science, Vol 63, Iss 5, Pp 643-654 (2020)
Objective\ud The therapeutic benefits of poly(ADP-ribose) polymerase inhibitors highlight the need to evaluate BRCA1/2 defects in tubal/ovarian cancer (OC). We sought to determine the pattern and disease characteristics associated with tumor BRCA1/2
Autor:
David Robert Grimes, E. Corry, Donal J. Brennan, Talía Malagón, Eduardo L. Franco, Ciaran O'Riain
Objective To quantify the impact and accuracy of different screening approaches for cervical cancer, including liquid based cytology (LBC), molecular testing for human papillomavirus (HPV) infection, and their combinations via parallel co-testing and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8309aa248c31230134dc2ed71eb33556
https://doi.org/10.21203/rs.3.rs-24189/v1
https://doi.org/10.21203/rs.3.rs-24189/v1
Autor:
Catherine J. Kennedy, Amy Short, Ian Harley, Tracy Robson, W. Glenn McCluggage, Mark Bates, Anna deFazio, Fiona Furlong, Anita Yakkundi, Helen O. McCarthy, Cian M. McCrudden, John J. O'Leary, Donal J. Brennan, Gillian Moore, Nermeen Moustafa, Laura Nelson, Sharon O'Toole, Sudipto Das, Lana McClements, Stephanie Annett, Alison Brand, Darran P. O'Connor, Adrien Kissenpfennig, Raghwa Sharma, Andrea Marshall, Ciaran O'Riain
Publikováno v:
Annett, S, Moore, G, Short, A, Marshall, A, McCrudden, C, Yakkundi, A, Das, S, McCluggage, W G, Nelson, L, Harley, I, Moustafa, N, Kennedy, C J, deFazio, A, Brand, A, Sharma, R, Brennan, D, O'Toole, S, O'Leary, J, Bates, M, O'Riain, C, O'Connor, D, Furlong, F, McCarthy, H, Kissenpfennig, A, McClements, L & Robson, T 2020, ' FKBPL-based peptide, ALM201, targets angiogenesis and cancer stem cells in ovarian cancer ', British Journal of Cancer, vol. 2020, no. 126, pp. 361 . https://doi.org/10.1038/s41416-019-0649-5
British Journal of Cancer
British Journal of Cancer
Background ALM201 is a therapeutic peptide derived from FKBPL that has previously undergone preclinical and clinical development for oncology indications and has completed a Phase 1a clinical trial in ovarian cancer patients and other advanced solid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b5cfaa907dbcf4bc7183b58d1c0c388
https://hdl.handle.net/10453/137191
https://hdl.handle.net/10453/137191
Autor:
Ciaran O'Riain, Jolanta Kupryjanczyk, Karen H. Lu, Bryan T. Hennessy, Ilary Ruscito, John J. O'Leary, Elizabeth M. Swisher, Stephen F. Madden, Gordon B. Mills, Julie M. Cunningham, Jalid Sehouli, Herbert Yu, Dionyssios Katsaros, Sharon O'Toole, Britta K. Stordal, Norman Häfner, Roshni Kalachand, David Thomas, Jessica N. McAlpine, Parvesh Chaudhry, Simon A. Joosse, Kirsten Timms, Ingo B. Runnebaum, Sarah S. Bernards, Mark S. Carey, Atanas Ignatov, Elena Ioana Braicu, Katharina Prieske, David D.L. Bowtell, Benjamin C. Chandler, Ellen L. Goode, Linn Woelber, Agnieszka Podgorska, Iwona K. Rzepecka
Publikováno v:
J Natl Cancer Inst
BackgroundBRCA1 methylation has been associated with homologous recombination deficiency, a biomarker of platinum sensitivity. Studies evaluating BRCA1-methylated tubal and ovarian cancer (OC) do not consistently support improved survival following p
Autor:
David Robert Grimes, Ciaran O'Riain, Donal J. Brennan, Talía Malagón, Eduardo L. Franco, E. Corry
Publikováno v:
JAMA Network Open
Key Points Question As human papillomavirus (HPV)–based cervical screening modalities change and HPV vaccination becomes more widespread, what are the likely outcomes for the interpretation of screening modalities? Findings In this decision analyti
Autor:
Brendan, Ffrench, Claudia, Gasch, Karsten, Hokamp, Cathy, Spillane, Gordon, Blackshields, Thamir Mahmoud, Mahgoub, Mark, Bates, Louise, Kehoe, Aoibhinn, Mooney, Ronan, Doyle, Brendan, Doyle, Dearbhaile, O'Donnell, Noreen, Gleeson, Bryan T, Hennessy, Britta, Stordal, Ciaran, O'Riain, Helen, Lambkin, Sharon, O'Toole, John J, O'Leary, Michael F, Gallagher
Publikováno v:
Cell Death & Disease
It is long established that tumour-initiating cancer stem cells (CSCs) possess chemoresistant properties. However, little is known of the mechanisms involved, particularly with respect to the organisation of CSCs as stem-progenitor-differentiated cel
Autor:
Aoibhinn Mooney, Cathy Spillane, Bryan T. Hennessy, Karsten Hokamp, Louise Kehoe, Noreen Gleeson, Claudia Gasch, Ronan Doyle, Britta K. Stordal, Brendan Ffrench, Sharon O'Toole, John J. O'Leary, Dearbhaile M. O'Donnell, Thamir Mahmoud Mahgoub, Michael Gallagher, Brendan Doyle, Ciaran O'Riain, Helen Lambkin, Gordon Blackshields, Mark Bates
Publikováno v:
Articles
It is long established that tumour-initiating cancer stem cells (CSCs) possess chemoresistant properties. However, little is known of the mechanisms involved, particularly with respect to the organisation of CSCs as stem-progenitor-differentiated cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36b3cd016ae39a1f19f5b540a722cb3d
https://arrow.tudublin.ie/scschbioart/176
https://arrow.tudublin.ie/scschbioart/176
Autor:
Andreas Rosenwald, Erlend B. Smeland, T. Andrew Lister, Sameena Iqbal, Vera Grossmann, John G. Gribben, Alexander Kohlmann, George E. Wright, Lisa M. Rimsza, Claude Chelala, Nikolay Popov, German Ott, Robert Kerrin Hills, Randy D. Gascoyne, Andrew Clear, King Tan, Abigail M. Lee, Hajnalka Rajnai, Olivier Elemento, Wing C. Chan, Louis M. Staudt, Shamzah Araf, Ciaran O'Riain, Jessica Okosun, Rita M. Braziel, Janet Matthews, Torsten Haferlach, Jun Wang, Jacek Marzec, Elias Campo, András Matolcsy, Jude Fitzgibbon, Silvia Montoto, Csaba Bödör
Publikováno v:
Scopus-Elsevier
Gain of function mutations in the H3K27 methyltransferase EZH2 represent a promising therapeutic target in germinal center lymphomas. In this study, we assessed the frequency and distribution of EZH2 mutations in a large cohort of patients with folli
Autor:
Silvia Montoto, David Wrench, Hilmar Quentmeier, Sunil Iyengar, Hans G. Drexler, Ciaran O'Riain, Andrew Clear, John G. Gribben, Janet Matthews, Jude Fitzgibbon, Sameena Iqbal, Mariarita Calaminici, András Matolcsy, H Tayyib, Andrew Lister, Csaba Bödör
Publikováno v:
Leukemia. 25:726-729