Zobrazeno 1 - 10
of 120
pro vyhledávání: '"Ciaran M. Regan"'
Publikováno v:
Neural Plasticity, Vol 7, Iss 4, Pp 279-289 (2000)
Spine density change in the hippocampal dentate gyrus accompanies memory consolidation and coincides with the increased expression of ribosome-rich, hyperchromatic granule cells. Although this suggests increased protein synthesis to be required for s
Externí odkaz:
https://doaj.org/article/e13d926c595a4da9b73b82f0bada644d
Publikováno v:
European Journal of Pharmacology. 727:80-86
In utero exposure of rodents to valproic acid (VPA) has been proposed to induce an adult phenotype with behavioural characteristics reminiscent of those observed in autism spectrum disorder (ASD). Our previous studies have demonstrated the social cog
Autor:
Vera C. Lau, Catarina Rendeiro, Andrew G. Foley, Ciaran M. Regan, Rebecca M Ring, David Vauzour, Claire M. Williams, Ana Rodriguez-Mateos, Jeremy P. E. Spencer
Publikováno v:
Neuropharmacology
The increase in incidence and prevalence of neurodegenerative diseases highlights the need for a more comprehensive understanding of how food components may affect neural systems. In particular, flavonoids have been recognized as promising agents cap
Autor:
Eliezer Masliah, Jessica M. Mc Donald, Margarita Trejo, Alexandra J. Mably, Dominic M. Walsh, Gilyana Borlikova, Keith J. Murphy, Ciaran M. Regan, Carlo Sala Frigerio
Publikováno v:
Neurobiology of Aging; Vol 34
Aggregation of the amyloid β-protein (Aβ) is believed to play a central role in initiating the molecular cascade that culminates in Alzheimer-type dementia (AD), a disease which in its early stage is characterized by synaptic loss and impairment of
Autor:
Mark Pickering, Bartlomiej Lukasz, Ciaran M. Regan, Niamh C. O’Sullivan, Jennifer S. Loscher, Keith J. Murphy
Publikováno v:
Brain, Behavior, and Immunity. 27:71-79
A range of adverse, early life environmental influences such as viral infection and social deprivation are thought to increase risk of psychiatric illness later in life. Here, we used peripheral administration of the viral infection mimic polyriboino
Autor:
Darren Scully, Dominic M. Walsh, Ciaran M. Regan, Rocio Fedriani, Darragh B. Freir, Imelda M. Smith, Dennis J. Selkoe
Publikováno v:
Neurobiology of Aging; Vol 32
Extensive research has implicated the amyloid-β protein (Aβ) in the aetiology of Alzheimer’s disease (AD). This protein has been shown to produce memory deficits when injected into rodent brain and in mouse models of AD Aβ production is associat
Autor:
Nanette Rombach, Robert H. Ring, Caitlin Wantuch, Darren Scully, Andrew W. Cassidy, Olive McCabe, Zoë A. Hughes, Rocio Fedriani, Menelas N. Pangalos, Angela T. Brady, Paul A. McGettigan, Mary P. Moran, Ciaran M. Regan, S.K. Mulvany, Christine Li, Niamh C. O’Sullivan, Jennifer S. Loscher, William T. O'Connor, Keith J. Murphy, Joanna Connellan, Desmond G. Higgins, Ian E. J. DeSouza, David von Schack, Bartlomiej Lukasz, Laura M. Connole, Karen L. Marquis, Judith P. F. Ter Horst, Marina Morgunova
Publikováno v:
Journal of Neurochemistry. 113:601-614
J. Neurochem. (2010) 113, 601–614. Abstract The critical sequence of molecular, neurotransmission and synaptic disruptions that underpin the emergence of psychiatric disorders like schizophrenia remain to be established with progress only likely us
Autor:
Andrew D. Medhurst, Ciaran M. Regan, Claire Barry, Darren Scully, Alison Prendergast, Andrew G. Foley, Neil Upton
Publikováno v:
Neuropsychopharmacology. 34:2585-2600
To further understand the procognitive actions of GSK189254, a histamine H(3) receptor antagonist, we determined its influence on the modulation of hippocampal neural cell adhesion molecule (NCAM) polysialylation (PSA) state, a necessary neuroplastic
Publikováno v:
Neuroscience. 157:813-820
Processing of information for long-term storage requires specific patterns of activity that lead to modification of synapse structure and eventual change in neural connectivity pattern. Morphological change associated with memory consolidation is rel
Autor:
Jennifer S. Loscher, Keith J. Murphy, Mark Pickering, Judith P. F. Ter Horst, Ciaran M. Regan
Publikováno v:
European Journal of Neuroscience. 28:419-427
The prefrontal cortex (PFC) is an interconnected set of cortical areas that function in the synthesis of a diverse range of information and production of complex behaviour. It is now clear that these frontal structures, through bidirectional excitato