Global analysis of neuropeptide receptor conservation across phylum Nematoda

Autor: Luca Golinelli, Ellen Geens, Allister Irvine, Ciaran J. McCoy, Elke Vandewyer, Louise E. Atkinson, Angela Mousley, Liesbet Temmerman, Isabel Beets

Publikováno v: BMC Biology, Vol 22, Iss 1, Pp 1-21 (2024)

Abstract Background The phylum Nematoda is incredibly diverse and includes many parasites of humans, livestock, and plants. Peptide-activated G protein-coupled receptors (GPCRs) are central to the regulation of physiology and numerous behaviors, and

Externí odkaz: https://doaj.org/article/c2d670455c1b439c9fcacc8998ab993e

Evaluation of changes in drug susceptibility and population genetic structure in Haemonchus contortus following worm replacement as a means to reverse the impact of multiple-anthelmintic resistance on a sheep farm

Autor: Melissa M. George, Adriano F. Vatta, Sue B. Howell, Bob E. Storey, Ciaran J. McCoy, Adrian J. Wolstenholme, Elizabeth M. Redman, John S. Gilleard, Ray M. Kaplan

Publikováno v: International Journal for Parasitology: Drugs and Drug Resistance, Vol 15, Iss , Pp 134-143 (2021)

A population of Haemonchus contortus that was highly resistant to benzimidazoles and avermectin/milbemycins with a subpopulation that was resistant to levamisole, was replaced with a susceptible laboratory isolate of H. contortus in a flock of sheep.

Externí odkaz: https://doaj.org/article/daffe7448bdc4defb193cf34c0e7a820

Recognition and killing of Brugia malayi microfilariae by human immune cells is dependent on the parasite sample and is not altered by ivermectin treatment

Autor: Barbara J. Reaves, Connor Wallis, Ciaran J. McCoy, W. Walter Lorenz, Balazs Rada, Adrian J. Wolstenholme

Publikováno v: International Journal for Parasitology: Drugs and Drug Resistance, Vol 8, Iss 3, Pp 587-595 (2018)

Mass administration of macrocyclic lactones targets the transmission of the causative agents of lymphatic filariasis to their insect vectors by rapidly clearing microfilariae (Mf) from the circulation. It has been proposed that the anti-filarial acti

Externí odkaz: https://doaj.org/article/94e10d01df374f65935f8dd6f0a09d75

In silico analyses of neuropeptide-like protein (NLP) profiles in parasitic nematodes

Autor: Angela Mousley, Aaron G. Maule, Ciaran J. McCoy, Louise E. Atkinson, Fiona M. McKay, Nikki J. Marks, Bethany A. Crooks

Publikováno v: McKay, F M, McCoy, C J, Crooks, B, Marks, N J, Maule, A G, Atkinson, L E & Mousley, A 2022, ' In silico analyses of neuropeptide-like protein (NLP) profiles in parasitic nematodes ', International Journal for Parasitology, vol. 52, no. 1, pp. 77-85 . https://doi.org/10.1016/j.ijpara.2021.07.002
International Journal for Parasitology

Graphical abstract
Highlights • Parasites possess a reduced complement of Caenorhabditis elegans neuropeptide-like protein (NLP)-encoding genes. • Parasite NLP profiles are broadly conserved between nematode clades. • Five NLP-encoding gen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e681e1277b5358905f20167f0ad7544
https://doi.org/10.1016/j.ijpara.2021.07.002

Human Leukocytes Kill Brugia malayi Microfilariae Independently of DNA-Based Extracellular Trap Release.

Autor: Ciaran J McCoy, Barbara J Reaves, Steeve Giguère, Ruby Coates, Balázs Rada, Adrian J Wolstenholme

Publikováno v: PLoS Neglected Tropical Diseases, Vol 11, Iss 1, p e0005279 (2017)

BACKGROUND:Wuchereria bancrofti, Brugia malayi and Brugia timori infect over 100 million people worldwide and are the causative agents of lymphatic filariasis. Some parasite carriers are amicrofilaremic whilst others facilitate mosquito-based disease

Externí odkaz: https://doaj.org/article/a9c9978a135c483e93810f3938886800