Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Ciara Tierney"'
Autor:
Filippos T Charitidis, Elham Adabi, Naphang Ho, Angela H Braun, Ciara Tierney, Lisa Strasser, Frederic B Thalheimer, Liam Childs, Jonathan Bones, Colin Clarke, Christian J Buchholz
Publikováno v:
Advanced Science, Vol 10, Iss 35, Pp n/a-n/a (2023)
Abstract Lentiviral vectors (LV) have become the dominant tool for stable gene transfer into lymphocytes including chimeric antigen receptor (CAR) gene delivery to T cells, a major breakthrough in cancer therapy. Yet, room for improvement remains, es
Externí odkaz:
https://doaj.org/article/059f2ee4b5674eeeac1c531a469404a9
Autor:
Ciara Tierney, Despina Bazou, Muntasir M. Majumder, Pekka Anttila, Raija Silvennoinen, Caroline A. Heckman, Paul Dowling, Peter O’Gorman
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract With the introduction of novel therapeutic agents, survival in Multiple Myeloma (MM) has increased in recent years. However, drug-resistant clones inevitably arise and lead to disease progression and death. The current International Myeloma
Externí odkaz:
https://doaj.org/article/108cd3dd8b6c4ba986fd1fc4eda995a5
Autor:
Rosanna Rossi, Oana Madalina Mereuta, Mariel Barbachan e Silva, Sara Molina Gil, Andrew Douglas, Abhay Pandit, Michael Gilvarry, Ray McCarthy, Shane O'Connell, Ciara Tierney, Klearchos Psychogios, Georgios Tsivgoulis, István Szikora, Turgut Tatlisumak, Alexandros Rentzos, John Thornton, Pilib Ó Broin, Karen M. Doyle
Publikováno v:
Frontiers in Neurology, Vol 13 (2022)
Background and AimsBesides the crucial role in the treatment of acute ischemic stroke (AIS), mechanical thrombectomy represents a unique opportunity for researchers to study the retrieved clots, with the possibility of unveiling biological patterns l
Externí odkaz:
https://doaj.org/article/0c1d9f9774fd4b6b982886a6547810e3
Autor:
Minxia Liu, Yinyin Wang, Juho J. Miettinen, Romika Kumari, Muntasir Mamun Majumder, Ciara Tierney, Despina Bazou, Alun Parsons, Minna Suvela, Juha Lievonen, Raija Silvennoinen, Pekka Anttila, Paul Dowling, Peter O’Gorman, Jing Tang, Caroline A. Heckman
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Despite several new therapeutic options, multiple myeloma (MM) patients experience multiple relapses and inevitably become refractory to treatment. Insights into drug resistance mechanisms may lead to the development of novel treatment strategies. Th
Externí odkaz:
https://doaj.org/article/ebd1a0e2671e4755b6242ea4919a4c67
Autor:
Lilian Pereira Silva, Dean Frawley, Leandro José de Assis, Ciara Tierney, Alastair B. Fleming, Ozgur Bayram, Gustavo Henrique Goldman
Publikováno v:
mSphere, Vol 5, Iss 5 (2020)
ABSTRACT The high-osmolarity glycerol (HOG) response pathway is a multifunctional signal transduction pathway that specifically transmits ambient osmotic signals. Saccharomyces cerevisiae Hog1p has two upstream signaling branches, the sensor histidin
Externí odkaz:
https://doaj.org/article/6b56b88db1ca4c4ab3654382f42d62bb
Autor:
Paul Dowling, Ciara Tierney, Katie Dunphy, Juho J. Miettinen, Caroline A. Heckman, Despina Bazou, Peter O’Gorman
Publikováno v:
Proteomes, Vol 9, Iss 4, p 42 (2021)
Acute myeloid leukemia (AML) is characterized by an increasing number of clonal myeloid blast cells which are incapable of differentiating into mature leukocytes. AML risk stratification is based on genetic background, which also serves as a means to
Externí odkaz:
https://doaj.org/article/6849e7a2dbd34a158d0fc5706886522a
Autor:
Alan O'Hare, Sara Molina, Jeanette Carlqvist, Klearchos Psychogios, Dennis Dunker, Ágnes Vadász, Georgios Magoufis, Annika Nordanstig, Seán Fitzgerald, Ray McCarthy, Karen M. Doyle, Michael Gilvarry, Rosanna Rossi, Ciara Tierney, Katarina Jood, Alexandros Rentzos, John Thornton, István Szikora, Erik Ceder, Andrew Douglas, Petra Redfors, Sarah Power, Turgut Tatlisumak, Paul Brennan, Abhay Pandit, András Nagy, Oana Madalina Mereuta, Georgios Tsivgoulis
Publikováno v:
Journal of Neurology. 269:1913-1920
Background and purpose There is still much debate whether bridging-therapy [intravenous thrombolysis (IVT) prior to mechanical thrombectomy (MT)] might be beneficial compared to MT alone. We investigated the effect of IVT on size and histological com
Autor:
Marina Castro-Rivadeneyra, Ioanna Tzani, Paul Kelly, Lisa Strasser, Felipe Guapo, Ciara Tierney, Michelle Chain, Lin Zhang, Martin Clynes, Barry L. Karger, Niall Barron, Jonathan Bones, Colin Clarke
Chinese hamster ovary (CHO) cells are used to produce almost 90% of therapeutic monoclonal antibodies (mAbs). The annotation of non-canonical translation events in these cellular factories remains incomplete, limiting not only our ability to study CH
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e542ec0a048420331458321dd0f2797
https://doi.org/10.1101/2022.01.20.475618
https://doi.org/10.1101/2022.01.20.475618
Autor:
Peter O'Gorman, Jacob P. Laubach, Michael E. O'Dwyer, Janusz Krawczyk, Andrew J. Yee, Oonagh Gilligan, Mary R. Cahill, Jacalyn Rosenblatt, John Quinn, Philip T. Murphy, Heidi DiPietro, Meegahage Ratnakanthi Perera, Gerard M. Crotty, Kristen Cummings, Patrick J. Hayden, Paul Browne, Alexandra Savell, Hilary M. O'Leary, Denis O'Keeffe, Kelly Masone, Brian J. Hennessy, Thomas Guerrero Garcia, Kathleen Scott, Khalid Saeed, Giada Bianchi, Paul Dowling, Ciara Tierney, Paul G. Richardson
Publikováno v:
American journal of hematologyREFERENCES. 97(5)
There are limited prospective data on lenalidomide, subcutaneous bortezomib, and dexamethasone (RsqVd) in transplant-eligible/transplant-ineligible patients with newly diagnosed multiple myeloma. Reliable biomarkers for efficacy and toxicity are requ
Autor:
Juho J. Miettinen, Paul Dowling, Katie Dunphy, Despina Bazou, Peter O'Gorman, Ciara Tierney, Caroline A. Heckman
Publikováno v:
Proteomes, Vol 9, Iss 42, p 42 (2021)
Proteomes
Volume 9
Issue 4
Proteomes
Volume 9
Issue 4
Acute myeloid leukemia (AML) is characterized by an increasing number of clonal myeloid blast cells which are incapable of differentiating into mature leukocytes. AML risk stratification is based on genetic background, which also serves as a means to